Results 111 to 120 of about 376 (138)

Continuous twin screw melt granulation of glyceryl behenate: Development of controlled release tramadol hydrochloride tablets for improved safety

International Journal of Pharmaceutics, 2015
Interest in granulation processes using twin screw extrusion machines is rapidly growing. The primary objectives of this study were to develop a continuous granulation process for direct production of granules using this technique with glyceryl behenate as a binder, evaluate the properties of the resulting granules and develop controlled release ...
Justin M, Keen, Connor J, Foley, Justin R, Hughey, Ryan C, Bennett, Vincent, Jannin, Yvonne, Rosiaux, Delphine, Marchaud, James W, McGinity   +7 more
openaire   +2 more sources

Using twin-screw melt granulation to co-process mannitol and hydroxypropylcellulose

Journal of Drug Delivery Science and Technology, 2022
Adwait Pradhan, Mark Costello, Fengyuan Yang, Vivian Bi, Thomas Durig, Feng Zhang   +5 more
openaire   +1 more source

High-dose modified-release formulation of a poorly soluble drug via twin-screw melt coating and granulation

International Journal of Pharmaceutics
Favipiravir, a high dose antiviral drug effective for oral treatment for COVID-19, with poor water solubility is formulated using a simple, low-cost melt coating and granulation methodology. High-dose (82.5 % w/w API) tablets (600 mg and 800 mg) with desired release profiles are developed while minimizing excipient burden.
Shashwat, Gupta, Thamer, Omar, Qiushi, Zhou, James, Scicolone, Gerardo, Callegari, Atul, Dubey, Fernando, Muzzio   +6 more
openaire   +2 more sources

Using Twin-Screw Melt Granulation to Co-Process Mannitol and Hydroxypropylcellulose (Klucel™)

SSRN Electronic Journal, 2022
Adwait Pradhan, Mark Costello, Fengyuan Yang, Vivian Bi, Thomas Durig, Feng Zhang   +5 more
openaire   +1 more source

Material-sparing degradation-kinetics model for thermolabile drug stability assessment during twin-screw melt granulation – Insights with gabapentin

International Journal of Pharmaceutics
Twin-Screw Melt Granulation (TSMG) has emerged as a viable manufacturing process for continuous granulation due to short residence time (
Adwait, Pradhan, Fengyuan, Yang, Kapish, Karan, Thomas, Durig, Quyen, Schwing, Brian, Haight, Mark, Costello, Mark, Anderson, Feng, Zhang   +8 more
openaire   +2 more sources

Chemically circular, mechanically tough, and melt-processable polyhydroxyalkanoates

Science, 2023
, Zhen Zhang, Changxia Shi
exaly  

A Binary Hydrate‐Melt Electrolyte with Acetate‐Oriented Cross‐Linking Solvation Shells for Stable Zinc Anodes

Advanced Materials, 2022
Zhi-Qiang Niu
exaly  

Seismic evidence for partial melt below tectonic plates

Nature, 2020
Eric Debayle, Thomas Bodin, Stephanie Durand   +2 more
exaly  

Hydrate-melt electrolytes for high-energy-density aqueous batteries

Nature Energy, 2016
Yuki Yamada, Seongjae Ko, Atsuo Yamada
exaly  

Ash-related issues during biomass combustion: Alkali-induced slagging, silicate melt-induced slagging (ash fusion), agglomeration, corrosion, ash utilization, and related countermeasures

Progress in Energy and Combustion Science, 2016
Yanqing Niu, Houzhang Tan
exaly