Results 21 to 30 of about 55 (42)

A colourful way to unravel the important fluidization-related granule size effect on semi-continuous drying

, 2023
Continuous twin screw wet granulation (TSWG) systems are possible pathways for oral solid dosage manufacturing in the pharmaceutical industry. TSWG requires a drying step after granulation before the tableting process.
De Beer, ThomasFW020019972147418010016996780000-0001-6296-0443F69EB3AE-F0ED-11E1-A9DE-61C894A0A6B4, Ghijs, MichaelFW020000905303028020019244740000-0002-6398-88162404E3A4-F0EE-11E1-A9DE-61C894A0A6B4, Nopens, IngmarLA260019942824128010013710900000-0001-6670-3700F5D054AA-F0ED-11E1-A9DE-61C894A0A6B4, Vandeputte, Tuur0001405439068020031986129732006041180000-0002-9802-8903F1955D56-297E-11E4-BFA2-63FCB4D1D7B1   +3 more
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Formulation of a High-Volume Small Molecule Drug Product [PDF]

, 2021
Small molecule drug products play an enormous role in innovative treatments for a vast number of diseases and have comprised most annual FDA drug approvals each year to date.
Onosode, Ogheneruteyan, Shah, Reeti, Watkins, Carolyn   +2 more
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Evaluation of the influence of material properties and process parameters on granule porosity in twin-screw wet granulation

, 2023
In recent years, continuous twin-screw wet granulation (TSWG) is gaining increasing interest from the pharmaceutical industry. Despite the many publications on TSWG, only a limited number of studies focused on granule porosity, which was found to be an ...
Barrera Jiménez, Ana Alejandra, De Beer, Thomas, Matsunami, Kensaku, Nopens, Ingmar, Peeters, Michiel, Stauffer, Fanny   +5 more
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An advanced twin‑screw granulation technology: the use of non‑volatile solvents with high solubilizing capacity [PDF]

Purpose Twin-screw wet granulation (TSWG) is a manufacturing process that ofers several advantages for the processing of water-insoluble active pharmaceutical ingredients (APIs) and has been used for increasing the solubility and dissolution rates ...
Bhatt, Saumil, Douroumis, Dionysios, Garg, Vivek, Junqueira, Laura Andrade, Kolipaka, Siva Satyanarayana, Mithu, Md Sadeque Hossain, Ross, Steven   +6 more
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Linking material properties to 1D-PBM parameters towards a generic model for twin-screw wet granulation

, 2023
Population balance models (PBM) have been widely used to model the twin-screw wet granulation (TSWG) in the continuous manufacturing of solid dosage forms.
Barrera Jiménez, Ana Alejandra, De Beer, Thomas, dos Santos Schultz, Eduardo, Kumar, Ashish, Matsunami, Kensaku, Nopens, Ingmar, Peeters, Michiel, Stauffer, Fanny, Van Hauwermeiren, Daan   +8 more
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Faster to First-time-in-Human: Prediction of the liquid solid ratio for continuous wet granulation

, 2022
In early development, when active pharmaceutical ingredient (API) is in short supply, it would be beneficial to reduce the number of experiments by predicting a suitable L/S ratio before starting the product development.
Blomberg, Andreas, Gholami, Aida, Junnila, Atte, Ketolainen, Jarkko, Megarry, Andrew, Papathanasiou, Foteini, Tajarobi, Pirjo, Wikström, Håkan   +7 more
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TWIN SCREW WET AND DRY GRANULATION [PDF]

, 2017
Twin screw granulation has gained wide interest by pharmaceutical manufacturing and the industry is still trying to expand its application. This thesis will further explore this technique and try to develop a new granulation strategy based on similar ...
Liu, Yang
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ADVANCING CONTINUOUS MANUFACTURING: THE ROLE OF PROCESS ANALYTICAL TECHNOLOGY IN PROCESS DEVELOPMENT [PDF]

The pharmaceutical industry is actively pursuing technologies which improve manufacturing processes with the goal of producing high-quality pharmaceutical products for patients, manifesting in an industry-wide investment in continuous manufacturing (CM).
Henson, Samuel R.
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Mechanistic modeling of twin screw wet granulation for pharmaceutical formulations : calibration, sensitivity analysis, and model-driven workflow [PDF]

Wet granulation, a particle size enlargement process, can significantly enhance the critical quality attributes of powders and improve the ability to form tablets in pharmaceutical manufacturing.
Ahmed, Bilal, Bala, Neeru, Corrigan, Jeremiah, Dawson, Neil, Doshi, Pankaj, Iyer, Kiran, Lee, Kai, Litster, James D., Meyer, Jonathan, Rowland, Martin, Schongut, Marek, Smith, Rachel M.   +11 more
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Analysis of the effect of formulation properties and process parameters on granule formation in twin-screw wet granulation

In the last few years, twin-screw wet granulation (TSWG) has become one of the key continuous pharmaceutical unit operations. Despite the many studies that have been performed, only little is known about the effect of the starting material properties on ...
Barrera Jiménez, Ana Alejandra00018151286480200299026297498991502254E10A42-C5C8-11E8-8987-A2685607D3EF, De Beer, ThomasFW020019972147418010016996780000-0001-6296-0443F69EB3AE-F0ED-11E1-A9DE-61C894A0A6B4, dos Santos Schultz, Eduardo, Ghijs, MichaelGE30FW020000905303028020019244740000-0002-6398-88162404E3A4-F0EE-11E1-A9DE-61C894A0A6B4, Matsunami, KensakuFW020001907414068020037291790000-0002-8831-018Xfa74b9bb-f129-11e9-843f-92d8df47a88d, Nopens, IngmarLA260019942824128010013710900000-0001-6670-3700F5D054AA-F0ED-11E1-A9DE-61C894A0A6B4, Peeters, Michiel0001412872678020029468169771395764781DF01E9E-9DD4-11E4-99AF-9C7DB5D1D7B1, Roudgar, Mina, Stauffer, Fanny, Vigh, Tamas   +9 more
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