Results 111 to 120 of about 639 (150)
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Twin screw wet granulation: Binder delivery
International Journal of Pharmaceutics, 2015The effects of three ways of binder delivery into the twin screw granulator (TSG) on the residence time, torque, properties of granules (size, shape, strength) and binder distribution were studied. The binder distribution was visualised through the transparent barrel using high speed imaging as well as quantified using offline technique.
Mohammed F, Saleh +4 more
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A review of twin screw wet granulation mechanisms in relation to granule attributes
Drug Development and Industrial Pharmacy, 2021Due to the trend of continuous pharmaceutical manufacturing, twin screw wet granulation (TSWG), a continuous process, has gained increased research interest as a potential substitution of traditional batch granulation processes. Despite the complex nature of TSWG, its mechanisms have been gradually unveiled with the aid of innovative research ...
Yi, Zhang +3 more
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Twin Screw Granulation as a Simple and Efficient Tool for Continuous Wet Granulation
International Journal of Pharmaceutics, 2004The modification of a twin screw extruder for continuous wet granulation was investigated. Modification of the extruder setup as well as the screw design allowed the continuous wet granulation of alpha-lactose monohydrate without the need of a wet sieving step.
A Vermeire, J P Remon, J P Remon
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Wet Granulation in a Twin‐Screw Extruder: Implications of Screw Design
Journal of Pharmaceutical Sciences, 2010Wet granulation in twin-screw extrusion machinery is an attractive technology for the continuous processing of pharmaceuticals. The performance of this machinery is integrally tied to its screw design yet little fundamental knowledge exists in this emerging field for granulation to intelligently create, troubleshoot, and scale-up such processes.
M R, Thompson, J, Sun
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Granulation of increasingly hydrophobic formulations using a twin screw granulator
International Journal of Pharmaceutics, 2014The application of twin screw granulation in the pharmaceutical industry has generated increasing interest due to its suitability for continuous processing. However, an understanding of the impact of formulation properties such as hydrophobicity on intermediate and finished product quality has not yet been established.
Shen, Yu +4 more
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Impact of screw elements on continuous granulation with a twin-screw extruder
Journal of Pharmaceutical Sciences, 2008The influence of different screw element types on wet granulation process with a twin-screw extruder was investigated. Lactose granules were prepared with different screw configurations such as conveying, combing mixer and kneading elements. The use of kneading blocks led to an almost complete agglomeration of lactose, whereas kneading and combing ...
Dejan, Djuric, Peter, Kleinebudde
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Continuous Twin Screw Granulation: Influence of Process Variables on Granule and Tablet Quality [PDF]
European Journal of Pharmaceutics and Biopharmaceutics, 2012 The aim of the current study was to screen theophylline (125 mg) tablets manufactured via twin screw granulation in order to improve process understanding and knowledge of process variables that determine granule and tablet quality. A premix of theophylline anhydrate, α-lactose monohydrate and PVP (ratio: 30/67.5/2.5,w/w) was granulated with ...
Chris Vervaet +2 more
exaly +4 more sources
Twin-screw melt granulation: Current progress and challenges
International Journal of Pharmaceutics, 2020Twin-screw melt granulation (TSMG) is a new alternative method for granulation that offers several advantages over wet and dry granulation methods. TSMG has rapidly gained interest over recent years in the pharmaceutical industry. Since it is an inherently continuous process with controlled temperature and shear history, TSMG produces products with ...
Nada Kittikunakorn +2 more
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Twin screw granulation – review of current progress
Drug Development and Industrial Pharmacy, 2014Twin screw granulation (TSG) is a new process of interest to the pharmaceutical community that can continuously wet granulate powders, doing so at lower liquid concentrations and with better product consistency than found by a high shear batch mixer. A considerable body of research has evolved over the short time since this process was introduced but ...
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Comparison of two twin-screw extruders for continuous granulation
European Journal of Pharmaceutics and Biopharmaceutics, 2009A comparison was made between two twin-screw extruders (APV Baker and Leistritz Micro) used for continuous wet granulation. Both extruders had similar screw configurations, based on the length-to-diameter ratio of the screws, existing out of a conveying zone of 20 D, i.e. 20 times the screw diameter and a granulation zone of 4D.
D, Djuric +4 more
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