Results 41 to 50 of about 29,018 (198)
TWIST1 homodimers and heterodimers orchestrate lineage-specific differentiation [PDF]
Molecular and Cellular Biology, 2019 AbstractThe extensive array of bHLH transcription factors and their combinations as dimers underpin the diversity of molecular function required for cell type specification during embryogenesis. The bHLH factor TWIST1 plays pleiotropic roles during development. However, which combinations of TWIST1 dimers are involved and what impact each dimer imposes
Fan, Xiaochen +8 more
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mSphere, 2020 Human papillomaviruses (HPVs) are causative agents in around 5% of all cancers, including cervical and oropharyngeal. A feature of HPV cancers is their better clinical outcome compared with non-HPV anatomical counterparts.
Christian T. Fontan +7 more
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TGIF1-Twist1 axis in pancreatic ductal adenocarcinoma
Computational and Structural Biotechnology Journal, 2020 TG-interacting factor 1 (TGIF1) exerts inhibitory effects on transforming growth factor-beta (TGF-β) signaling by suppressing Smad signaling pathway at multiple levels. TGIF1 activity is important for normal embryogenesis and organogenesis, yet its dysregulation can culminate in tumorigenesis. For instance, increased expression of TGIF1 correlates with
Mohammed S. Razzaque, Azeddine Atfi
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Interference of p53:Twist1 interaction through competing nanobodies
International Journal of Biological Macromolecules, 2022 Twist1 promote the bypass of p53 response by interacting with p53 and facilitating its MDM2-mediated degradation. We reasoned that reagents able to interfere with the p53:Twist1 complex might alleviate Twist1 inhibitory effect over p53, thus representing potential therapeutic tools in p53 wild type tumors. From a pre-immune library of llama nanobodies (
D'Agostino S. +8 more
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JCI Insight, 2021 The transcription factor Twist1 regulates several processes that could impact kidney disease progression, including epithelial cell differentiation and inflammatory cytokine induction.
Jiafa Ren +9 more
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MiR-337-3p Promotes Adipocyte Browning by Inhibiting TWIST1
Cells, 2020 The prevalence of metabolic syndrome (MetS) and obesity is an alarming health issue worldwide. Obesity is characterized by an excessive accumulation of white adipose tissue (WAT), and it is associated with diminished brown adipose tissue (BAT) activity ...
Indira G.C. Vonhögen +8 more
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TWIST1 is expressed in colorectal carcinomas and predicts patient survival. [PDF]
PLoS ONE, 2011 TWIST1 is a transcription factor that belongs to the family of basic helix-loop-helix proteins involved in epithelial-to-mesenchymal transition and invasion processes.
Irene Gomez +11 more
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Negative regulation of the androgen receptor gene through a primate specific androgen response element present in the 5' UTR [PDF]
, 2014 Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Hay, Colin W +5 more
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Abstract 1969: PKCα-induced Twist1 phosphorylation is a novel regulator of Twist1 stabilization
Cancer Research, 2017 Abstract Background: Epithelial - mesenchymal transition (EMT) is a pre-requisite for cancer metastasis. Twist-1 is a transcription factor with a central role in the process of EMT and therefore metastasis formation.
Roslyn Tedja +8 more
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FOXD3 modulates migration through direct transcriptional repression of TWIST1 in melanoma. [PDF]
, 2014 UNLABELLED: The neural crest is a multipotent, highly migratory cell population that gives rise to diverse cell types, including melanocytes. Factors regulating the development of the neural crest and emigration of its cells are likely to influence ...
Abel, E V +3 more
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