Results 41 to 50 of about 22,249 (182)

Comparison of Twist1:Ubc-CreERT2 CKO embryo forelimb phenotype after tamoxifen injection at E9.5 with embryos that overexpress Twist1 monomer or Twist1-Hand2, Twist1-E12 or Twist1-Twist1 tethered dimers. [30].

, 2014
Comparison of Twist1:Ubc-CreERT2 CKO embryo forelimb phenotype after tamoxifen injection at E9.5 with embryos that overexpress Twist1 monomer or Twist1-Hand2, Twist1-E12 or Twist1-Twist1 tethered dimers. [30].
David A. F. Loebel (571663), Patrick P. L. Tam (385055), Angelyn C. C. Hor (571664), Heidi K. Bildsoe (571665)   +3 more
core   +1 more source

Assessment of TWIST1 as an immunotherapeutic target of cancer [PDF]

, 2011
CD8+ T lymphocytes are key mediators of anti-tumour immunity, eliminating tumour cells through the recognition of tumour antigens. Increasing the number of characterised tumour antigens, especially those with highly specific tumour expression, may enable
Poon, E.C.C.
core  

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Deciphering the interaction between Twist1 and PPARγ during adipocyte differentiation

Cell Death and Disease, 2023
Obesity, a worldwide epidemic in recent years, is mainly due to the uncontrolled development of adipose tissues, which includes adipocyte hypertrophy and hyperplasia. Adipocyte differentiation is a process involving multiple transcription factor cascades,
Leilei Sun, Shaoping Ji, Xuan Xie, Lei Si, Shaohao Liu, Yao Lin, Yahui Wang, Zhenhua Song, Na Fang, Yang An, Jian Yang   +10 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

MAML1 promotes ESCC aggressiveness through upregulation of EMT marker TWIST1.

, 2021
BackgroundMastermind-like 1 (MAML1) is the main transcriptional co-activator of Notch signaling pathway. It plays essential roles in several pathways including MEF2C, p53, Nf-кB and Wnt/β-catenin.
Morshedi Rad, D, Forghanifard, MM, Ardalan Khales, S, Abbaszadegan, MR, Azaraz, S   +4 more
core   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

Expression of EMT transcription factors Twist1 and Slug in benign and malignant thyroid tumors

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Papillary thyroid carcinoma (PTC) usually has a favorable prognosis; however, lymph node metastases, extrathyroidal extension, and radioiodine refractoriness significantly contribute to recurrence and reduced survival.
P.P. Zinych, V.M. Pushkarev, N.I. Levchuk, Ye.A. Shelkovoi, M.Yu. Bolhov   +4 more
doaj   +1 more source

Abstract 1969: PKCα-induced Twist1 phosphorylation is a novel regulator of Twist1 stabilization

, 2017
Background: Epithelial - mesenchymal transition (EMT) is a pre-requisite for cancer metastasis. Twist-1 is a transcription factor with a central role in the process of EMT and therefore metastasis formation.
Gang Yin, Yang Yang-Hartwich, Carlos Cardenas, Roslyn Tedja, Ayesha B. Alvero, Mary Pitruzzello, Carlotta Glackin, Gil G. Mor, Cai Roberts   +8 more
core   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source