Results 31 to 40 of about 29,018 (198)

DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells.

PLoS ONE, 2015
Twist1 overexpression is frequently observed in various cancers including gastric cancer (GC). Although DNA methylation of the Twist1 gene has been reported in cancer cells, the mechanisms underlying transcriptional activation remain uncertain.
Ayuna Sakamoto, Yoshimitsu Akiyama, Shu Shimada, Wei-Guo Zhu, Yasuhito Yuasa, Shinji Tanaka   +5 more
doaj   +1 more source

Absolute quantitation of DNA methylation of 28 candidate genes in prostate cancer using pyrosequencing [PDF]

, 2011
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Aberrant DNA methylation plays a pivotal
Beltran, L, Berney, DM, Brentnall, AR, Cuzick, J, Kim, DC, Kudahetti, SC, Lorincz, AT, Lu, YJ, Mao, XY, Shaw, GL, Thorat, MA, Vasiljevic, N, Wu, KQ, Xue, LY, Yu, YW   +14 more
core   +2 more sources

TWIST1 Gene: First Insights in Felis catus [PDF]

Current Genomics, 2010
TWIST1 is thought to be a novel oncogene. Understanding the molecular mechanisms regulating the TWIST1 gene expression profiles in tumor cells may give new insights regarding prognostic factors and novel therapeutic targets in veterinary oncology.
Baptista, Cláudia S., Santos, Sara, Gut, Ivo G., Gärtner, Fátima, Bastos, Estela, Chaves, Raquel, Guedes-Pinto, Henrique   +6 more
openaire   +3 more sources

Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. [PDF]

PLoS Genetics, 2012
KRAS mutant lung cancers are generally refractory to chemotherapy as well targeted agents. To date, the identification of drugs to therapeutically inhibit K-RAS have been unsuccessful, suggesting that other approaches are required. We demonstrate in both
Phuoc T Tran, Emelyn H Shroff, Timothy F Burns, Saravanan Thiyagarajan, Sandhya T Das, Tahera Zabuawala, Joy Chen, Yoon-Jae Cho, Richard Luong, Pablo Tamayo, Tarek Salih, Khaled Aziz, Stacey J Adam, Silvestre Vicent, Carsten H Nielsen, Nadia Withofs, Alejandro Sweet-Cordero, Sanjiv S Gambhir, Charles M Rudin, Dean W Felsher   +19 more
doaj   +1 more source

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. [PDF]

, 2016
The epithelial-mesenchymal transition (EMT) endows carcinoma cells with phenotypic plasticity that can facilitate the formation of cancer stem cells (CSCs) and contribute to the metastatic cascade.
Banno, Asoka, Bui, Jack D, Chang, Aaron N, Chang, John T, Fisch, Kathleen, Florea, Bogdan I, Garcia, Daniel A, Geurink, Paul P, Kim, Stephanie H, Lopez, Justine, Metz, Patrick J, Ovaa, Huib, Overkleeft, Hermen S, van Baarsel, Eric D, Widjaja, Christella E, Yang, Jing   +15 more
core   +2 more sources

LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. [PDF]

, 2014
Transcriptional elongation by RNA polymerase (Pol) II is essential for gene expression during cell growth and differentiation. The positive transcription elongation factor b (P-TEFb) stimulates transcriptional elongation by phosphorylating Pol II and ...
Ji, Xiaodan, Lu, Huasong, Luo, Kunxin, Zhou, Qiang   +3 more
core   +3 more sources

Emerging role of Twist1 in fibrotic diseases [PDF]

Journal of Cellular and Molecular Medicine, 2018
AbstractEpithelial–mesenchymal transition (EMT) is a pathological process that occurs in a variety of diseases, including organ fibrosis. Twist1, a basic helix–loop–helix transcription factor, is involved in EMT and plays significant roles in various fibrotic diseases.
Xiaoxuan Ning, Kun Zhang, Qingfeng Wu, Minna Liu, Shiren Sun   +4 more
openaire   +2 more sources

miR-9-5p Exerts a Dual Role in Cervical Cancer and Targets Transcription Factor TWIST1

Cells, 2019
Squamous cell carcinoma (SCC) and adenocarcinoma (AC) represent the major cervical cancer histotypes. Both histotypes are caused by infection with high-risk HPV (hrHPV) and are associated with deregulated microRNA expression.
Iris Babion, Annelieke Jaspers, Annina P. van Splunter, Iris A.E. van der Hoorn, Saskia M. Wilting, Renske D.M. Steenbergen   +5 more
doaj   +1 more source

TWIST1 activates cancer stem cell marker genes to promote epithelial-mesenchymal transition and tumorigenesis in esophageal squamous cell carcinoma

BMC Cancer, 2022
Background Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers worldwide. Overexpression of EMT master transcription factors can promote differentiated cells to undergo cancer reprogramming processes and acquire a stem cell-like ...
Sima Ardalan Khales, Sina Mozaffari-Jovin, Dirk Geerts, Mohammad Reza Abbaszadegan   +3 more
doaj   +1 more source

Twist1 promotes radioresistance in nasopharyngeal carcinoma

Oncotarget, 2016
With the development of advanced imaging and radiation technologies, radiotherapy has been employed as the principal treatment approach for nasopharyngeal carcinoma (NPC). So far, a number of patients still suffer from the failure of this treatment due to the acquired radioresistance, but the underlying mechanisms are still poorly defined.
Zhang, Linli, Su, Beibei, Sun, Wei, Li, Wenwen, Luo, Min, Liu, Dongbo, Mei, Qi, Long, Guoxian, Hu, Guangyuan, Hu, Guoqing   +9 more
openaire   +3 more sources