Results 31 to 40 of about 22,249 (182)

Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. [PDF]

PLoS Genetics, 2012
KRAS mutant lung cancers are generally refractory to chemotherapy as well targeted agents. To date, the identification of drugs to therapeutically inhibit K-RAS have been unsuccessful, suggesting that other approaches are required. We demonstrate in both
Phuoc T Tran, Emelyn H Shroff, Timothy F Burns, Saravanan Thiyagarajan, Sandhya T Das, Tahera Zabuawala, Joy Chen, Yoon-Jae Cho, Richard Luong, Pablo Tamayo, Tarek Salih, Khaled Aziz, Stacey J Adam, Silvestre Vicent, Carsten H Nielsen, Nadia Withofs, Alejandro Sweet-Cordero, Sanjiv S Gambhir, Charles M Rudin, Dean W Felsher   +19 more
doaj   +1 more source

The Heterodimeric TWIST1-E12 Complex Drives the Oncogenic Potential of TWIST1 in Human Mammary Epithelial Cells [PDF]

, 2016
The TWIST1 embryonic transcription factor displays biphasic functions during the course of carcinogenesis. It facilitates the escape of cells from oncogene-induced fail-safe programs (senescence, apoptosis) and their consequent neoplastic transformation.
Collin, Guillaume, Jacqueroud, Laurent, Guillaume Collin, Agnès Tissier, Geoffrey Richard, Julie Caramel, Bouard, Charlotte, Alain Puisieux, Payen, Léa, Caramel, Julie, Ansieau, Stéphane, Stéphane Ansieau, Mojgan Devouassoux-Shisheboran, Richard, Geoffrey, Devouassoux-Shisheboran, Mojgan, Spicer, Douglas B., Charlotte Bouard, Tissier, Agnès, Léa Payen, Douglas B. Spicer, Puisieux, Alain, Laurent Jacqueroud   +21 more
core   +1 more source

TWIST1 activates cancer stem cell marker genes to promote epithelial-mesenchymal transition and tumorigenesis in esophageal squamous cell carcinoma

BMC Cancer, 2022
Background Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers worldwide. Overexpression of EMT master transcription factors can promote differentiated cells to undergo cancer reprogramming processes and acquire a stem cell-like ...
Sima Ardalan Khales, Sina Mozaffari-Jovin, Dirk Geerts, Mohammad Reza Abbaszadegan   +3 more
doaj   +1 more source

Human Papillomavirus 16 (HPV16) E2 Repression of TWIST1 Transcription Is a Potential Mediator of HPV16 Cancer Outcomes

mSphere, 2020
Human papillomaviruses (HPVs) are causative agents in around 5% of all cancers, including cervical and oropharyngeal. A feature of HPV cancers is their better clinical outcome compared with non-HPV anatomical counterparts.
Christian T. Fontan, Dipon Das, Molly L. Bristol, Claire D. James, Xu Wang, Hannah Lohner, Azeddine Atfi, Iain M. Morgan   +7 more
doaj   +1 more source

Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration

JCI Insight, 2021
The transcription factor Twist1 regulates several processes that could impact kidney disease progression, including epithelial cell differentiation and inflammatory cytokine induction.
Jiafa Ren, Yuemei Xu, Xiaohan Lu, Liming Wang, Shintaro Ide, Gentzon Hall, Tomokazu Souma, Jamie R. Privratsky, Robert F. Spurney, Steven D. Crowley   +9 more
doaj   +1 more source

The role of TWIST1 in vascular cells.

, 2020
A) Heat map showing the differential gene expression of TWIST1 and an early stage (ACTA2) and late stage (MYH11) differentiation marker of vascular SMCs in an in vitro differentiation model.
Ting Wang (16292), Sylvia T. Nurnberg (5663650), Robert C. Wirka (4354132), John Pluta (8275677), Stephanie Testa (8275680), Ulf Hedin (544142), Milos Pjanic (485288), Sanjay Sinha (140434), Daniel J. Rader (7658096), Christopher D. Brown (219934), Scott Norton (8275674), Wei Zhao (14321), YoSon Park (7331096), Felipe Serrano (540999), Susannah Elwyn (241991), Trieu Nguyen (26172), Yoseph Barash (48182), Ljubica Perisic (544141), Thomas Quertermous (94604), H. Shanker Rao (8275671), Yi-An Ko (5601593), Marie A. Guerraty (8275668)   +21 more
core   +1 more source

Eliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment

Molecular Therapy: Oncolytics, 2021
The potency of cancer vaccines is often compromised by a variety of immunoinhibitory mechanisms, including stimulation of the programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint pathway. Here, to overcome inhibition,
Zhiwu Tan, Mei Sum Chiu, Chi Wing Yan, Kwan Man, Zhiwei Chen   +4 more
doaj   +1 more source

The speckle-type POZ protein (SPOP) inhibits breast cancer malignancy by destabilizing TWIST1

Cell Death Discovery, 2022
Epithelial-mesenchymal transition (EMT) inducing transcription factor TWIST1 plays a vital role in cancer metastasis. How the tumor-suppressive E3 ligase, speckle-type POZ protein (SPOP), regulates TWIST1 in breast cancer remains unknown.
Chunli Wei, Yun Liu, Xiaoyan Liu, Jingliang Cheng, Jiewen Fu, Xiuli Xiao, Robb E. Moses, Xiaotao Li, Junjiang Fu   +8 more
doaj   +1 more source

Autoregulation of Th1-mediated inflammation by twist1 [PDF]

, 2008
The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor {kappa}B (NF-{kappa}B)–dependent cytokine expression, is involved in the regulation of inflammation-induced immunopathology.
Inka Albrecht, Hamann, Alf, Burmester, G., Andreas Radbruch, Koeck, Juliana, Sina Bartfeld, Max Löhning, Bonhagen, Kerstin, Löhning, Max, Chang, Hyun D., Chang, H., Gitelman, Inna, Bartfeld, S., Alexander Scheffold, Joachim Gruen, Daniel C. Baumgart, Burmester, G.R., Christoph Loddenkemper, Humrich, J., Thomas Häupl, Bartfeld, Sina, Sascha Rutz, Bertram Wiedenmann, Schulze-Topphoff, U., Albrecht, Inka, Loddenkemper, Christoph, Chang, H.D., Katharina Eulenburg, Janitz, Michal, Stephan Kreher, Janke, M., Krenn, Veit, Burmester, Gerd R., Häupl, T., Baumgart, D., Rudwaleit, M., Rutz, S., Schulze-Topphoff, Ulf, Jochen Sieper, Hegazy, A.N., Alf Hamann, Martin Rudwaleit, Scheffold, A., Eulenburg, Katharina, Janitz, M., Gruen, Joachim, Hamann, A., Kreher, Stephan, Jens Y. Humrich, Duchmann, R., Loddenkemper, C., Zeitz, M., Philipp Enghard, Martin Zeitz, Lexberg, Maria H., Thomas Kamradt, Maria H. Lexberg, Hegazy, Ahmed N., Ulf Schulze-Topphoff, Baumgrass, R., Sieper, Jochen, Sieper, J., Albrecht, I., Niesner, U., Humrich, J.Y., Kamradt, T., Juliana Koeck, Ria Baumgrass, Baumgrass, Ria, Gerd R. Burmester, Orhan Aktas, Ahmed N. Hegazy, Kamradt, Thomas, Rudwaleit, Martin, Lexberg, M.H., Enghard, Philipp, Uwe Niesner, Inna Gitelman, Bonhagen, K., Rutz, Sascha, Wiedenmann, B., Doebis, Cornelia, Wiedenmann, Bertram, Niesner, Uwe, Duchmann, Rainer, Hyun D. Chang, Kerstin Bonhagen, Zipp, Frauke, Doebis, C., Koeck, J., Humrich, Jens Y., Löhning, M., Rainer Duchmann, Cornelia Doebis, Gitelman, I., Veit Krenn, Baumgart, D.C., Eulenburg, K., Kreher, S., Baumgart, Daniel C., Zeitz, Martin, Radbruch, A., Hegazy, A., Zipp, F., Radbruch, H., Frauke Zipp, Janke, Marko, Radbruch, Helena, Aktas, Orhan, Enghard, P., Lexberg, M., Aktas, O., Krenn, V., Radbruch, Andreas, Marko Janke, Helena Radbruch, Häupl, Thomas, Scheffold, Alexander, Michal Janitz, Gruen, J.   +119 more
core   +1 more source

Reactivation of TWIST1 contributes to Ewing sarcoma metastasis [PDF]

, 2017
BACKGROUND: Ewing sarcoma is a cancer of bone and soft tissue. Despite aggressive treatment, survival remains poor, particularly in patients with metastatic disease.
Robert Newbury, Jing Yang, Newbury, Robert, Roberts, William, Yang, Jing, Sun Choo, Ping Wang, William Roberts, Wang, Ping, Choo, Sun   +9 more
core   +1 more source