Results 11 to 20 of about 29,018 (198)
Obesity Inhibits Angiogenesis Through TWIST1-SLIT2 Signaling [PDF]
Frontiers in Cell and Developmental Biology, 2021 Angiogenesis is required for functional adipose tissue maintenance, remodeling, and expansion. Physiologically balanced adipogenesis and angiogenesis are inhibited in subcutaneous adipose tissue in obese humans.
Tendai Hunyenyiwa +9 more
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Twist1 Suppresses Cementoblast Differentiation [PDF]
Dentistry Journal, 2018 The transcription factor Twist1 is known to be closely associated with the formation of bone by mesenchymal stem cells and osteoblasts; however, the role of Twist1 in cementogenesis has not yet been determined.
Jung-Sun Moon +5 more
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Neoplasia: An International Journal for Oncology Research, 2016 The TWIST1 embryonic transcription factor displays biphasic functions during the course of carcinogenesis. It facilitates the escape of cells from oncogene-induced fail-safe programs (senescence, apoptosis) and their consequent neoplastic transformation.
Laurent Jacqueroud +10 more
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Methylation of the TWIST1 Promoter, TWIST1 mRNA Levels, and Immunohistochemical Expression of TWIST1 in Breast Cancer [PDF]
Cancer Epidemiology, Biomarkers & Prevention, 2008 Abstract TWIST1, an antiapoptotic and prometastatic transcription factor, is overexpressed in many epithelial cancers including breast. Only little is known regarding the regulation of TWIST1 in these cancers. Recently, an increase in the TWIST1 promoter methylation has been shown in breast cancers.
Eelke H, Gort +6 more
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Twist1-Induced Epithelial Dissemination Requires Prkd1 Signaling [PDF]
Cancer Research, 2020 Abstract Dissemination is an essential early step in metastasis but its molecular basis remains incompletely understood. To define the essential targetable effectors of this process, we developed a 3D mammary epithelial culture model, in which dissemination is induced by overexpression of the ...
Dan Georgess +8 more
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Frontiers in Oncology, 2020 The epithelial-mesenchymal transition (EMT) is a vital step in osteosarcoma (OS) progression toward metastasis, but the specific molecular events governing this process are incompletely characterized, with miRNAs having increasingly been found to ...
Shu-tao Zhu +4 more
doaj +1 more source
FEBS Open Bio, 2021 TWIST1 is an important basic helix‐loop‐helix protein linked to multiple physiological and pathological processes. Although TWIST1 is believed to be involved in vascular pathogenesis, its effects on homeostasis of smooth muscle cells (SMCs) remain poorly
Jing Zhang +7 more
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Endothelial TWIST1 Promotes Pathological Ocular Angiogenesis [PDF]
Investigative Ophthalmology & Visual Science, 2014 Pathological neovessel formation impacts many blinding vascular eye diseases. Identification of molecular signatures distinguishing pathological neovascularization from normal quiescent vessels is critical for developing new interventions. Twist-related protein 1 (TWIST1) is a transcription factor important in tumor and pulmonary angiogenesis.
Jie, Li +10 more
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Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valves. [PDF]
PLoS ONE, 2011 Twist1, a basic helix-loop-helix transcription factor, is expressed in mesenchymal precursor populations during embryogenesis and in metastatic cancer cells.
Mary P Lee, Katherine E Yutzey
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LncRNA-TWIST1 Promoted Osteogenic Differentiation Both in PPDLSCs and in HPDLSCs by Inhibiting TWIST1 Expression [PDF]
BioMed Research International, 2019 HPDLSCs derived from periodontal ligament tissues contribute to tooth development and tissue regeneration. Exploring the effects of long noncoding RNAs (lncRNAs) in the process of osteogenic differentiation of periodontal ligament stem cells would provide novel therapeutic strategies for tissue regeneration.
Yuerong Xu +5 more
openaire +2 more sources