Twist Family BHLH Transcription Factor 1 orchestrates hypoxia-lactate crosstalk to bridge glycolytic flux and tubular maladaptation in fibrotic kidneys [PDF]
Molecular BiomedicineThe reprogramming of glycolytic metabolism is essential for maintaining the reparative homeostasis of tubular epithelial cells (TECs). Maladaptive TEC repair mechanisms drive the progression from acute kidney injury (AKI) to chronic kidney disease (CKD).
Zhixiang Yu +9 more
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Structure-Function Studies of the bHLH Phosphorylation Domain of TWIST1 in Prostate Cancer Cells
Neoplasia, 2015 The TWIST1 gene has diverse roles in development and pathologic diseases such as cancer. TWIST1 is a dimeric basic helix-loop-helix (bHLH) transcription factor existing as TWIST1-TWIST1 or TWIST1-E12/47.
Reem Malek +2 more
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Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions
Advanced Science, 2023 Triple‐negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, a key transcriptional factor of epithelial‐mesenchymal transition (EMT), contributes to self‐renewal of cancer stem‐like cells (CSCs), chemo ...
Tongzheng Liu, Hongxian Wang
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TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques [PDF]
Nature CommunicationsRupture of unstable atherosclerotic plaques is a major cause of mortality. Endothelial-to-mesenchymal transition associates with advanced atherosclerotic plaques and contributes to plaque progression.
Blanca Tardajos Ayllon +18 more
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Androgen up-regulation of Twist1 gene expression is mediated by ETV1 [PDF]
PeerJ, 2020 Twist1, a basic helix-loop-helix transcription factor that regulates a number of genes involved in epithelial-to-mesenchymal transition (EMT), is upregulated in prostate cancer. Androgen regulation of Twist1 has been reported in a previous study. However,
Prabesh Khatiwada +4 more
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FEBS Open Bio, 2021 TWIST1 is an important basic helix‐loop‐helix protein linked to multiple physiological and pathological processes. Although TWIST1 is believed to be involved in vascular pathogenesis, its effects on homeostasis of smooth muscle cells (SMCs) remain poorly
Jing Zhang +7 more
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Hypertension in Pregnancy, 2021 Purpose This study is aimed to elucidate the molecular mechanism of lncRNA SNHG7 on pre-eclampsia (PE). Methods The expression of SNHG7, miR-214-5p and TWIST1 in PE placental tissues was detected by qRT-PCR.
Yongping Wang, Zhihui Zhang
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Regulatory Role of the Transcription Factor Twist1 in Cancer-Associated Muscle Cachexia
Frontiers in Physiology, 2020 Muscle cachexia is a catabolic response, usually takes place in various fatal diseases, such as sepsis, burn injury, and chronic kidney disease. Muscle cachexia is also a common co-morbidity seen in the vast majority of advanced cancer patients, often ...
Mohammed S. Razzaque, Azeddine Atfi
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CBX7 regulates metastasis of basal-like breast cancer through Twist1/EphA2 pathway
Translational Oncology, 2022 Background: Basal-like breast cancer (BLBC) is an important subtype of breast cancer. Twist1 is a key transcription factor in BLBC metastasis, which serves a key role in tumorigenesis.
Tao Dai +3 more
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Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valves. [PDF]
PLoS ONE, 2011 Twist1, a basic helix-loop-helix transcription factor, is expressed in mesenchymal precursor populations during embryogenesis and in metastatic cancer cells.
Mary P Lee, Katherine E Yutzey
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