Results 1 to 10 of about 29,018 (198)

Functional analysis of TWIST1 domains regulating smooth muscle cell phenotype [PDF]

Frontiers in Cardiovascular Medicine
IntroductionTWIST1, a bHLH transcription factor, regulates mesenchymal specification, differentiation, proliferation and migration during development and in diseases such as cancer. More recently, genome-wide association studies have identified TWIST1 as
Danielle C. M. Dy, Thiel Lehman, Adrian Othon, Mitesh Rathod, William J. Polacheck, Robert Wirka, Robert Wirka, Robert Wirka   +7 more
doaj   +2 more sources

Structure-Function Studies of the bHLH Phosphorylation Domain of TWIST1 in Prostate Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2015
The TWIST1 gene has diverse roles in development and pathologic diseases such as cancer. TWIST1 is a dimeric basic helix-loop-helix (bHLH) transcription factor existing as TWIST1-TWIST1 or TWIST1-E12/47.
Rajendra P. Gajula, Sivarajan T. Chettiar, Russell D. Williams, Katriana Nugent, Yoshinori Kato, Hailun Wang, Reem Malek, Kekoa Taparra, Jessica Cades, Anvesh Annadanam, A-Rum Yoon, Elana Fertig, Beth A. Firulli, Lucia Mazzacurati, Timothy F. Burns, Anthony B. Firulli, Steven S. An, Phuoc T. Tran   +17 more
doaj   +3 more sources

TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques [PDF]

Nature Communications
Rupture of unstable atherosclerotic plaques is a major cause of mortality. Endothelial-to-mesenchymal transition associates with advanced atherosclerotic plaques and contributes to plaque progression.
Blanca Tardajos Ayllon, Mannekomba Diagbouga, Ankita Das, Siyu Tian, Andreas Edsfeldt, Joanna Kalucka, Jovana Serbanovic-Canic, Emily Chambers, Jiangming Sun, Chrysostomi Gialeli, Mark Dunning, Sheila E. Francis, Xiuying Li, Akiko Mammoto, Michael Simons, Helle F. Jørgensen, Isabel Goncalves, Suowen Xu, Paul C. Evans   +18 more
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Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions

Advanced Science, 2023
Triple‐negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, a key transcriptional factor of epithelial‐mesenchymal transition (EMT), contributes to self‐renewal of cancer stem‐like cells (CSCs), chemo ...
Tangming Guan, Mei Li, Yan Song, Jiayi Chen, Jiaxin Tang, Caishi Zhang, Yalei Wen, Xiao Yang, Lei Huang, Yingjie Zhu, Hongxian Wang, Ke Ding, Junxia Zheng, Haoxing Zhang, Tongzheng Liu   +14 more
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lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling

Molecular Cancer, 2020
Background MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination are well established, but the involvement of long noncoding RNAs (lncRNAs) in Twist1-mediated signaling remains largely unknown. Methods
Jinchang Pan, Shuai Fang, Haihua Tian, Chengwei Zhou, Xiaodong Zhao, Hui Tian, Jinxian He, Weiyu Shen, Xiaodan Meng, Xiaofeng Jin, Zhaohui Gong   +10 more
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TWIST1 promotes invasion through mesenchymal change in human glioblastoma

Molecular Cancer, 2010
Background Tumor cell invasion into adjacent normal brain is a mesenchymal feature of GBM and a major factor contributing to their dismal outcomes.
Wakimoto Hiroaki, Glackin Carlotta A, Maxwell John-Patrick, Oxford Robert G, Khorasani Leila, Beyer Richard, Petit Audrey, Mikheev Andrei M, Mikheeva Svetlana A, González-Herrero Inés, Sánchez-García Isidro, Silber John R, Horner Philip J, Rostomily Robert C   +13 more
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Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts [PDF]

, 2013
The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes.
A Mansukhani, AK Coussens, BD Stamper, BK Huang, BU Ang, C Owen, C Yao, CB Harvey, CH Shackleton, CW Li, D Gomez, D Johnson, DC Robinson, DP Rice, DT Gault, G Radetti, G Ramajayam, GA Brent, GM Morriss-Kay, GR Williams, H Kohara, H Miraoui, HJ Kim, J Connerney, J Esparza, J Zumbrunn, JA Greenwald, Jack C. Yu, James J. Cray, JH Bassett, JH Oh, JL Penfold, JM Britto, JQ Feng, JS Morey, K Kasono, KA Kapp-Simon, Kameron Khaksarfard, KM Lee, M Bodo, M Menking, M Segni, MH Sheng, MM Cohen Jr, Mohammed Elsalanty, PJ Marie, R Rice, S Akita, S Wadhwa, S Weiss, SA Boyadjiev, SA Rasmussen, Seth M. Weinberg, W Arlt, W Riggs Jr, WM Chadduck, Xing-Ming Shi, Y Xiong, Z von Marschall   +58 more
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Increased expression of lncRNA SNHG7 promotes the cell viability, migration, and invasion in pre-eclampsia via modulating the miR-214-5p/TWIST1 axis

Hypertension in Pregnancy, 2021
Purpose This study is aimed to elucidate the molecular mechanism of lncRNA SNHG7 on pre-eclampsia (PE). Methods The expression of SNHG7, miR-214-5p and TWIST1 in PE placental tissues was detected by qRT-PCR.
Yongping Wang, Zhihui Zhang
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Androgen up-regulation of Twist1 gene expression is mediated by ETV1 [PDF]

PeerJ, 2020
Twist1, a basic helix-loop-helix transcription factor that regulates a number of genes involved in epithelial-to-mesenchymal transition (EMT), is upregulated in prostate cancer. Androgen regulation of Twist1 has been reported in a previous study. However,
Prabesh Khatiwada, Archana Kannan, Mamata Malla, Megan Dreier, Lirim Shemshedini   +4 more
doaj   +2 more sources

CBX7 regulates metastasis of basal-like breast cancer through Twist1/EphA2 pathway

Translational Oncology, 2022
Background: Basal-like breast cancer (BLBC) is an important subtype of breast cancer. Twist1 is a key transcription factor in BLBC metastasis, which serves a key role in tumorigenesis.
Tao Dai, Yiqi Liu, Renxian Cao, Jingying Cao   +3 more
doaj   +1 more source