Regulatory Role of the Transcription Factor Twist1 in Cancer-Associated Muscle Cachexia
Frontiers in Physiology, 2020 Muscle cachexia is a catabolic response, usually takes place in various fatal diseases, such as sepsis, burn injury, and chronic kidney disease. Muscle cachexia is also a common co-morbidity seen in the vast majority of advanced cancer patients, often ...
Mohammed S. Razzaque, Azeddine Atfi
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miR-151-3p Targets TWIST1 to Repress Migration of Human Breast Cancer Cells. [PDF]
PLoS ONE, 2016 TWIST1 is a highly conserved basic helix-loop-helix transcription factor that contributes to cancer metastasis by promoting an epithelial-mesenchymal transition and repressing E-cadherin gene expression in breast cancer.
Ting-Chih Yeh +7 more
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Unraveling the transcriptional regulation of TWIST1 in limb development. [PDF]
PLoS Genetics, 2018 The transcription factor TWIST1 plays a vital role in mesoderm development, particularly in limb and craniofacial formation. Accordingly, haploinsufficiency of TWIST1 can cause limb and craniofacial malformations as part of Saethre-Chotzen syndrome ...
Naama Hirsch +9 more
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Communications Biology, 2022 TWIST1 and TWIST2 were found to display an opposed expression pattern, with TWIST1 associated with poor survival and TWIST2 with good prognosis. Functional studies revealed that TWIST1 promotes both primary and metastatic neuroblastoma (NB) tumor growth.
Maria-Vittoria Sepporta +11 more
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Identification of LIMK2 as a therapeutic target in castration resistant prostate cancer [PDF]
, 2019 This study identified LIMK2 kinase as a disease-specific target in castration resistant prostate cancer (CRPC) pathogenesis, which is upregulated in response to androgen deprivation therapy, the current standard of treatment for prostate cancer. Surgical
Broman, Meaghan M. +13 more
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TWIST1 (twist homolog 1 (Drosophila)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on TWIST1 (twist homolog 1 (Drosophila)), with data on DNA, on the protein encoded, and where the gene is implicated.
Valdés-Mora, F +2 more
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Key signalling nodes in mammary gland development and cancer: the snail1-twist1 conspiracy in malignant breast cancer progression [PDF]
, 2010 Breast cancer is the most common cancer among women, and despite significant advances in diagnosing and treating it, metastatic spread of cancer cells results in a high mortality rate. Epithelial-to-mesenchymal transition (EMT) is an embryonic program in
Foubert, Ellen +2 more
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Autoregulation of Th1-mediated inflammation by twist1 [PDF]
The Journal of Experimental Medicine, 2008 The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor κB (NF-κB)–dependent cytokine expression, is involved in the regulation of inflammation-induced immunopathology. We show that twist1 is expressed by activated T helper (Th) 1 effector memory (EM) cells.
Niesner, U. +37 more
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TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation
eLife, 2021 Protein interaction is critical molecular regulatory activity underlining cellular functions and precise cell fate choices. Using TWIST1 BioID-proximity-labeling and network propagation analyses, we discovered and characterized a TWIST-chromatin ...
Xiaochen Fan +8 more
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Cell line derived xenograft mouse models are a suitable in vivo model for studying tumor budding in colorectal cancer [PDF]
, 2019 Tumor budding (TB) is an important prognostic parameter in colorectal cancer (CRC) and associated with metastasis. However, the mechanisms of TB have not been fully elucidated and a major limitation is the absence of in vivo models.
Dawson, Heather +6 more
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