Results 21 to 30 of about 22,249 (182)

TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growth

Communications Biology, 2022
TWIST1 and TWIST2 were found to display an opposed expression pattern, with TWIST1 associated with poor survival and TWIST2 with good prognosis. Functional studies revealed that TWIST1 promotes both primary and metastatic neuroblastoma (NB) tumor growth.
Maria-Vittoria Sepporta, Viviane Praz, Katia Balmas Bourloud, Jean-Marc Joseph, Nicolas Jauquier, Nicolò Riggi, Katya Nardou-Auderset, Audrey Petit, Jean-Yves Scoazec, Hervé Sartelet, Raffaele Renella, Annick Mühlethaler-Mottet   +11 more
doaj   +1 more source

Unraveling the transcriptional regulation of TWIST1 in limb development. [PDF]

PLoS Genetics, 2018
The transcription factor TWIST1 plays a vital role in mesoderm development, particularly in limb and craniofacial formation. Accordingly, haploinsufficiency of TWIST1 can cause limb and craniofacial malformations as part of Saethre-Chotzen syndrome ...
Naama Hirsch, Reut Eshel, Reut Bar Yaacov, Tal Shahar, Fania Shmulevich, Idit Dahan, Noam Levaot, Tommy Kaplan, Darío G Lupiáñez, Ramon Y Birnbaum   +9 more
doaj   +1 more source

Obesity Inhibits Angiogenesis Through TWIST1-SLIT2 Signaling

Frontiers in Cell and Developmental Biology, 2021
Angiogenesis is required for functional adipose tissue maintenance, remodeling, and expansion. Physiologically balanced adipogenesis and angiogenesis are inhibited in subcutaneous adipose tissue in obese humans.
Tendai Hunyenyiwa, Tendai Hunyenyiwa, Kathryn Hendee, Kienna Matus, Priscilla Kyi, Priscilla Kyi, Tadanori Mammoto, Tadanori Mammoto, Akiko Mammoto, Akiko Mammoto   +9 more
doaj   +1 more source

miR-9-5p Exerts a Dual Role in Cervical Cancer and Targets Transcription Factor TWIST1

Cells, 2019
Squamous cell carcinoma (SCC) and adenocarcinoma (AC) represent the major cervical cancer histotypes. Both histotypes are caused by infection with high-risk HPV (hrHPV) and are associated with deregulated microRNA expression.
Iris Babion, Annelieke Jaspers, Annina P. van Splunter, Iris A.E. van der Hoorn, Saskia M. Wilting, Renske D.M. Steenbergen   +5 more
doaj   +1 more source

DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells.

PLoS ONE, 2015
Twist1 overexpression is frequently observed in various cancers including gastric cancer (GC). Although DNA methylation of the Twist1 gene has been reported in cancer cells, the mechanisms underlying transcriptional activation remain uncertain.
Ayuna Sakamoto, Yoshimitsu Akiyama, Shu Shimada, Wei-Guo Zhu, Yasuhito Yuasa, Shinji Tanaka   +5 more
doaj   +1 more source

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

eLife, 2021
Protein interaction is critical molecular regulatory activity underlining cellular functions and precise cell fate choices. Using TWIST1 BioID-proximity-labeling and network propagation analyses, we discovered and characterized a TWIST-chromatin ...
Xiaochen Fan, V Pragathi Masamsetti, Jane QJ Sun, Kasper Engholm-Keller, Pierre Osteil, Joshua Studdert, Mark E Graham, Nicolas Fossat, Patrick PL Tam   +8 more
doaj   +1 more source

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell-cell junctions during neural tube formation. [PDF]

Dev Dyn
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Thomas D, Hufft-Martinez BM, Lalwani Z, Pham V, Elmeniawi M, Tran AJ, Xu J, Saadi I, Fakhouri WD.   +8 more
europepmc   +2 more sources

Data_Sheet_1_Obesity Inhibits Angiogenesis Through TWIST1-SLIT2 Signaling.PDF

, 2021
Angiogenesis is required for functional adipose tissue maintenance, remodeling, and expansion. Physiologically balanced adipogenesis and angiogenesis are inhibited in subcutaneous adipose tissue in obese humans.
Priscilla Kyi (11497909), Kienna Matus (11497906), Tadanori Mammoto (72440), Kathryn Hendee (11497903), Akiko Mammoto (148118), Tendai Hunyenyiwa (11497900)   +5 more
core   +1 more source

Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis [PDF]

, 2011
SummaryThe Twist1 transcription factor is known to promote tumor metastasis and induce Epithelial-Mesenchymal Transition (EMT). Here, we report that Twist1 is capable of promoting the formation of invadopodia, specialized membrane protrusions for ...
Danis, Etienne, Lwin, Thinzar M., Ohno-Machado, Lucila, Etienne Danis, Lucila Ohno-Machado, Jing Yang, Mark A. Eckert, Andrew T. Chang, Kim, Jihoon, Jihoon Kim, Chang, Andrew T., Yang, Jing, Thinzar M. Lwin, Eckert, Mark A.   +13 more
core   +1 more source

TWIST1-reprogrammed endothelial cell transplantation potentiates neovascularization-mediated diabetic wound tissue regeneration

, 2020
Hypo-vascularised diabetic non-healing wounds are due to reduced number and impaired physiology of endogenous endothelial progenitor cell (EPC) population that, limits their recruitment and mobilization at the wound site.
Ada Admin (8524211), Komal Kaushik (8597778), Amitava Das (710288)   +2 more
core   +1 more source