Results 51 to 60 of about 29,018 (198)

Protein kinase Cα–mediated phosphorylation of Twist1 at Ser-144 prevents Twist1 ubiquitination and stabilizes it [PDF]

Journal of Biological Chemistry, 2019
Twist1 is a basic helix-loop-helix transcription factor that plays a key role in embryonic development, and its expression is down-regulated in adult cells. However, Twist1 is highly expressed during cancer development, conferring a proliferative, migratory, and invasive phenotype to malignant cells.
Roslyn Tedja, Cai M. Roberts, Ayesha B. Alvero, Carlos Cardenas, Yang Yang-Hartwich, Sydney Spadinger, Mary Pitruzzello, Gang Yin, Carlotta A. Glackin, Gil Mor   +9 more
openaire   +2 more sources

Twist1: A Double-Edged Sword in Kidney Diseases [PDF]

Kidney Diseases, 2020
<b><i>Background:</i></b> Twist1 is a basic helix-loop-helix domain containing transcription factor that regulates cell differentiation, migration, proliferation, survival, and inflammatory responses by transcriptionally regulating a wide range of downstream target genes.
Jiafa, Ren, Steven D, Crowley
openaire   +2 more sources

The speckle-type POZ protein (SPOP) inhibits breast cancer malignancy by destabilizing TWIST1

Cell Death Discovery, 2022
Epithelial-mesenchymal transition (EMT) inducing transcription factor TWIST1 plays a vital role in cancer metastasis. How the tumor-suppressive E3 ligase, speckle-type POZ protein (SPOP), regulates TWIST1 in breast cancer remains unknown.
Chunli Wei, Yun Liu, Xiaoyan Liu, Jingliang Cheng, Jiewen Fu, Xiuli Xiao, Robb E. Moses, Xiaotao Li, Junjiang Fu   +8 more
doaj   +1 more source

High TWIST1 mRNA expression is associated with poor prognosis in lymph node-negative and estrogen receptor-positive human breast cancer and is co-expressed with stromal as well as ECM related genes [PDF]

, 2012
Introduction: The TWIST homolog 1 (TWIST1) is a transcription factor that induces epithelial to mesenchymal transition (EMT), a key process in metastasis. The purpose of this study was to investigate whether TWIST1 expression predicts disease progression
A Bergamaschi, A Jemal, A Umar, AB Firulli, AM Sieuwerts, AM Sieuwerts, AM Sieuwerts, Anieta M Sieuwerts, B Thisse, D Hanahan, DG Altman, E Cosset, E Roman-Perez, F Valdes-Mora, GQ Ru, I Gomez, J Yang, JA Foekens, JG van Nes, John A Foekens, John WM Martens, JX Yu, KW Lee, LM McShane, M Leptin, M Smid, Marcel Smid, Maxime P Look, MC Elias, ME Fondrevelle, MH Yang, Mieke A Timmermans, Muhammad Riaz, P Farmer, S Valsesia-Wittmann, SA Mani, T Blick, T Okada, T van Agthoven, W Kress, W Tong, Y Benjamini, Y Soini, Y Wang   +43 more
core   +3 more sources

TRIM29 Suppresses TWIST1 and Invasive Breast Cancer Behavior [PDF]

Cancer Research, 2014
Abstract TRIM29 (ATDC) exhibits a contextual function in cancer, but seems to exert a tumor-suppressor role in breast cancer. Here, we show that TRIM29 is often silenced in primary breast tumors and cultured tumor cells as a result of aberrant gene hypermethylation.
Ai, Lingbao, Kim, Wan-Ju, Alpay, Merve, Tang, Ming, Pardo, Carolina E., Hatakeyama, Shigetsugu, May, W. Stratford, Kladde, Michael P., Heldermon, Coy D., Siegel, Erin M., Brown, Kevin D.   +10 more
openaire   +3 more sources

TWIST1 controls cellular senescence and energy metabolism in mesenchymal stem cells [PDF]

European Cells & Materials, 2021
Mesenchymal stem cells (MSCs) are promising cells for regenerative medicine therapies because they can differentiate towards multiple cell lineages. However, the occurrence of cellular senescence and the acquiring of the senescence-associated secretory ...
C Voskamp, LA Anderson, WJLM Koevoet, S Barnhoorn, PG Mastroberardino, GJVM van Osch, R Narcisi   +6 more
doaj   +1 more source

Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3. [PDF]

, 2017
Mesoderm derived from human embryonic stem cells (hESCs) is a major source of the mesenchymal stem/stromal cells (MSCs) that can differentiate into osteoblasts and chondrocytes for tissue regeneration.
Aghaloo, Tara, Deng, Peng, Hong, Christine, Szymanski, John M, Wang, Cun-Yu, Yu, Bo, Yu, Yongxin   +6 more
core   +2 more sources

Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]

, 2019
BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda, Farias-Eisner, Robin, Nava, Miguel, Vadgama, Jaydutt V, Wu, Yanyuan, Zemke, Nathan R   +5 more
core   +5 more sources

Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness [PDF]

Cancer Research, 2011
Abstract Twist1, a basic helix–loop–helix transcription factor, promotes breast tumor cell epithelial–mesenchymal transition (EMT), invasiveness, and metastasis. However, the mechanisms responsible for regulating Twist1 stability are unknown in these cells. We identified the serine 68 (Ser 68) as a major phosphorylation site of Twist1
Jun, Hong, Jian, Zhou, Junjiang, Fu, Tao, He, Jun, Qin, Li, Wang, Lan, Liao, Jianming, Xu   +7 more
openaire   +2 more sources

Mutant CFTR Drives TWIST1 mediated epithelial–mesenchymal transition [PDF]

Cell Death & Disease, 2020
AbstractCystic fibrosis (CF) is a monogenetic disease resulting from mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene encoding an anion channel. Recent evidence indicates that CFTR plays a role in other cellular processes, namely in development, cellular differentiation and wound healing.
Margarida C. Quaresma, Ines Pankonien, Luka A. Clarke, Luís S. Sousa, Iris A. L. Silva, Violeta Railean, Tereza Doušová, Jonas Fuxe, Margarida D. Amaral   +8 more
openaire   +2 more sources