Results 51 to 60 of about 22,249 (182)
Advanced Science, EarlyView.As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens +11 more
wiley +1 more source
TWIST1 suppresses osteogenic differentiation.
, 2013 (a). Quantitative RT-PCR analysis representing higher TWIST1 expression in transfected GCTT1, GCTT2 cells compared to untransfected (UT) GCT stromal cells. (b).
Shalini Singh (62344) +4 more
core +1 more source
Advanced Science, EarlyView.TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin +10 more
wiley +1 more source
Composition of TWIST1 dimers regulates fibroblast activation and tissue fibrosis
, 2017 OBJECTIVES: TWIST1 is a member of the class B of basic helix-loop-helix transcription factors that regulates cell lineage determination and differentiation and has been implicated in epithelial-to-mesenchymal transition. Here, we aimed to investigate the
Liebl, Andrea +17 more
core +1 more source
T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease
Advanced Science, EarlyView.This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li +11 more
wiley +1 more source
Regulation of AVC gene expression by TWIST1.
, 2012 A. Gene expression changes in Twist1 null AVC by Tag-seq. Expression of all tag-types mapping in the sense direction to the same RefSeq gene were pooled and all tag counts were normalized as tags per million reads sequenced.
Eric Xu (151289) +9 more
core +1 more source
Advanced Science, EarlyView.Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang +9 more
wiley +1 more source
TWIST1 expression in tumor samples.
, 2012 A. Assessment of TWIST1 expression by quantitative RT-PCR in EGFR mutated (M) and wild type (WT) tumors assessed by quantitative RT-PCR. B. Representative microphotographs (10×) of immunohistochemical expression of TWIST1 in primary EGFR mutated human ...
Pierre-Alexandre Just (187882) +12 more
core +1 more source
Kaplan-Maier OS curves and TWIST1 activity.
, 2013 A, Relation between expression levels of TWIST1 and SNAI2 genes, logR(T/N), in patients in which TWIST1 was previously detected. TWIST1 and SNAI2 expression directly correlates in human colon cancer, Pearson correlation coefficient r = 0.41 ...
Irene Gomez (354084) +11 more
core +1 more source
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source