Results 61 to 70 of about 29,018 (198)

Eliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment

Molecular Therapy: Oncolytics, 2021
The potency of cancer vaccines is often compromised by a variety of immunoinhibitory mechanisms, including stimulation of the programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint pathway. Here, to overcome inhibition,
Zhiwu Tan, Mei Sum Chiu, Chi Wing Yan, Kwan Man, Zhiwei Chen   +4 more
doaj   +1 more source

GATA4-Twist1 Signalling in Disturbed Flow-Induced Atherosclerosis [PDF]

Cardiovascular Drugs and Therapy, 2019
Endothelial cell (EC) dysfunction (enhanced inflammation, proliferation and permeability) is the initial trigger for atherosclerosis. Atherosclerosis shows preferential development near branches and bends exposed to disturbed blood flow. By contrast, sites that are exposed to non-disturbed blood flow are atheroprotected.
Mahmoud, M., Souilhol, C., Serbanovic-Canic, J., Evans, P.   +3 more
openaire   +2 more sources

BMI1 and TWIST1 Downregulated mRNA Expression in Basal Cell Carcinoma [PDF]

, 2014
Background: BMI1, TWIST1 and SNAI2/SLUG have been implicated in aggressive behavior of squamous cell carcinoma (SCC) and melanoma and BMI1 expression could identify subtypes of Merkel cell carcinoma (MCC).
Fathi, Hamidreza., Hashemzadeh-Chaleshtori, Morteza., Kamyab Hesari, Kambiz., Mirshams Shahshahani, Mostafa., Noormohammadpour, Pedram., Raoofian, Reza., Tabrizi, Mina., Vahidnezhad, Hassan., Vand Rajabpour, Fatemeh., Youssefian, Leila.   +9 more
core   +1 more source

Bovine polledness [PDF]

, 2012
The persistent horns are an important trait of speciation for the family Bovidae with complex morphogenesis taking place briefly after birth. The polledness is highly favourable in modern cattle breeding systems but serious animal welfare issues urge for
Blum, Helmut, Förster, Martin, Graf, Alexander, Göpel, Karl Heinrich, Krebs, Stefan, Medugorac, Ivica, Rothammer, Sophie, Russ, Ingolf, Seichter, Doris   +8 more
core   +1 more source

The Wnt-inducible Transcription Factor Twist1 Inhibits Chondrogenesis [PDF]

Journal of Biological Chemistry, 2006
Wnt signaling is essential for many developmental processes, including skeletogenesis. To investigate the effects of Wnt signaling during skeletogenesis we studied the effects of Wnt on cultured chondrocytic cells and differentiating limb-bud mesenchyme. We showed that Wnt3a strongly repressed chondrogenesis and chondrocyte gene expression.
Martina I, Reinhold, Ravi M, Kapadia, Zhixiang, Liao, Michael C, Naski   +3 more
openaire   +2 more sources

PTBP3 promotes tumorigenesis of glioblastoma by stabilizing Twist1

Translational Oncology, 2022
Abstract Glioblastoma (GBM) is the most common malignancy tumor of central nervous system. PTBP3 was closely associated with the development of tumor. However, the function and mechanism of PTBP3 in GBM is little known. We found that PTBP3 was upregulated in GBM, and higher expression of PTBP3 corrected with the poor survival of GBM patients ...
Peng Xie, Yueqing Zhang, Rui Chen, Jinyu Zheng, Gang Cui   +4 more
openaire   +3 more sources

Deciphering the interaction between Twist1 and PPARγ during adipocyte differentiation

Cell Death and Disease, 2023
Obesity, a worldwide epidemic in recent years, is mainly due to the uncontrolled development of adipose tissues, which includes adipocyte hypertrophy and hyperplasia. Adipocyte differentiation is a process involving multiple transcription factor cascades,
Leilei Sun, Shaoping Ji, Xuan Xie, Lei Si, Shaohao Liu, Yao Lin, Yahui Wang, Zhenhua Song, Na Fang, Yang An, Jian Yang   +10 more
doaj   +1 more source

TWIST1 Promoter Methylation in Primary Colorectal Carcinoma

Pathology & Oncology Research, 2011
TWIST1 gene, a transcription factor that belongs to the family of basic helix-loop-helix proteins, has been related to tumor progression and metastasis in different cancers. The aim of our study was to investigate TWIST1 promoter methylation in patients with primary colorectal carcinoma and determine its correlation with prognostic factors and disease ...
Rúbia D, Ruppenthal, Carmela, Nicolini, Antonio Fabiano Ferreira, Filho, Rosalva, Meurer, Andréa P, Damin, Adriana, Rohe, Cláudio O P, Alexandre, Daniel C, Damin   +7 more
openaire   +2 more sources

CXCL11 mediates TWIST1-induced angiogenesis in epithelial ovarian cancer

Tumor Biology, 2017
To investigate the role of TWIST1 in tumor angiogenesis in epithelial ovarian cancer and to identify key molecules involved in angiogenesis. TWIST1 small interfering RNA was transfected into A2780 cells, while a complementary DNA vector was transfected ...
Yu-Jin Koo, Tae-Jin Kim, Kyung-Jin Min, Kyeong-A So, Un-Suk Jung, Jin-Hwa Hong   +5 more
doaj   +1 more source

Ectopic expression of snail and twist in Ph+ leukemia cells upregulates CD44 expression and alters their differentiation potential [PDF]

, 2017
Philadelphia chromosome-positive (Ph+) leukemia is characterized by reciprocal translocation between chromosomes 9 and 22. The resultant BCR/ABL fusion protein displays constitutive tyrosine kinase activity, leading to the induction of aberrant ...
Dally, Najib, Eshel, Elizabeth, Khamaisie, Hazem, Kidan, Noa, Mahajna, Jamal, Roitman, Shay, Ruimi, Nili, Ruthardt, Martin   +7 more
core   +1 more source