Results 81 to 90 of about 22,249 (182)

Ectopic expression of TWIST1 upregulates the stemness marker OCT4 in the esophageal squamous cell carcinoma cell line KYSE30

Cellular & Molecular Biology Letters, 2017
Background The transcription factor TWIST1 plays an important role in the epithelial–mesenchymal transition (EMT) process and in the migration, invasion and metastasis of cancer cells. OCT4, which is a homeobox transcription factor, has an important role
Mohammad Hossein Izadpanah, Mohammad Reza Abbaszadegan, Yasaman Fahim, Mohammad Mahdi Forghanifard   +3 more
doaj   +1 more source

Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells in vitro by Forming a Complex With Tcf4 and β-Catenin

Frontiers in Cell and Developmental Biology, 2020
ObjectiveDuring hair follicle regeneration, hair follicle stem cells (HFSCs) are regulated by signals from dermal papilla cells (DPCs). Previously we found that Tcf4 could promote the proliferation of DPCs.
Nanlan Yu, Tianxing Hu, Tianxing Hu, Haichao Yang, Lian Zhang, Qin Song, Fei Xiang, Xichuan Yang, Yuhong Li   +8 more
doaj   +1 more source

Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos, Martin Olmos, Courtney P. Wood, Camila Alvarez, Haley M. Read, Parima Udompholkul, Theodore Garland Jr, Nicholas V. DiPatrizio   +7 more
wiley   +1 more source

M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine

OncoImmunology, 2018
Tumors evade host immune surveillance through multiple mechanisms, including the generation of a tumor microenvironment that suppresses immune effector function.
Karin M. Knudson, Kristin C. Hicks, Xiaoling Luo, Jin-Qiu Chen, Jeffrey Schlom, Sofia R. Gameiro   +5 more
doaj   +1 more source

Twist1 controls Tie2 expression in microvascular endothelial cells.

, 2013
A) Graph showing Twist1 and Tie2 mRNA levels in L-HMVE cells treated with Twist1 siRNA #1 or #2 ...
Aimee M. Juan (189067), Amanda Jiang (148112), Tadanori Mammoto (72440), Akiko Mammoto (148118), Yongbo Lu (145329), Elisabeth Jiang (148110), Jing Chen (4762)   +6 more
core   +1 more source

Beyond the Monolayer: Leveraging 3D Culture Systems to Decode Mechanisms of Drug Resistance and Therapeutic Vulnerabilities in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Two‐dimensional (2D) monolayer cultures remain the workhorse of colorectal cancer (CRC) research and high‐throughput screening (HTS), yet they poorly recapitulate tissue architecture, extracellular matrix (ECM) cues, metabolic gradients, and multicellular heterogeneity that govern drug response in vivo. Over the past decade, three‐dimensional (
Sarah J. Harmych, Bhuminder Singh
wiley   +1 more source

Modulation of MnSOD and FoxM1 is Involved in Invasion and EMT Suppression by Isovitexin in Hepatocellular Carcinoma Cells [Retraction]

Cancer Management and Research, 2022
Qiu Y, Cao X, Liu L, et al. Cancer Manag Res. 2020;12:5759‒5771. The Editor and Publisher of Cancer Management and Research wish to retract the published article.
Qiu Y, Cao X, Liu L, Cao X, Yuan Q, Li X, Cui Y, Xu C, Zou C, Ren K, Cao J   +10 more
doaj  

Craniofacial Morphology and Dental Age Assessment in Pediatric Craniosynostosis: A Comparative Cross‐Sectional Study

Clinical and Experimental Dental Research, Volume 12, Issue 5, October 2026.
ABSTRACT Objectives To delineate the craniofacial morphometric characteristics of Thai children with syndromic (SC) and non‐syndromic craniosynostosis (NSC) and to assess dental maturation relative to Chronological Age (CA). Methods This comparative cross‐sectional study evaluated 19 patients (SC: n = 13; NSC: n = 6; mean age 9.32 ± 2.67 years ...
Nutthakarn Ratanasereeprasert, Yanisa Wongbanthit, Narin Intarak, Preeya Suwanwitid, Chutimont Teekavanich, Anand Marya, Guang Hong, Thantrira Porntaveetus   +7 more
wiley   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Mechanism of ORC1 Regulating Cancer Stemness and Cisplatin Resistance in Non‐Small Cell Lung Cancer

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Elevated ORC1 expression in non‐small cell lung cancer (NSCLC) simultaneously activates cancer stemness and epithelial‐mesenchymal transition (EMT). Upregulation of stemness‐associated factors (NANOG, LGR5, CD133+CD44+ CSCs) and EMT transcription factors (SNAI1, SNAI2, TWIST1) synergistically induce MDR1 overexpression. Increased MDR1 ultimately drives
Jianhui Sheng, Yingjian Song
wiley   +1 more source