Results 81 to 90 of about 29,018 (198)
Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells [PDF]
, 2019 Metastatic competence of cancer cells is influenced by many factors including metabolic alterations and changes in mitochondrial biogenesis and protein homeostasis.
Daverey, Amita +8 more
core +1 more source
, 2017 Twist1 is a crucial transcription factor that regulates epithelial mesenchymal transition and involves in metastasis. Recent evidence suggests that Twist1 plays important role in hypoxia-induced radioresistance, but the underlying mechanism remains ...
Gong, Chen +12 more
core +1 more source
Androgen receptor-dependent and -independent mechanisms driving prostate cancer progression: Opportunities for therapeutic targeting from multiple angles. [PDF]
, 2016 Despite aggressive treatment for localized cancer, prostate cancer (PC) remains a leading cause of cancer-related death for American men due to a subset of patients progressing to lethal and incurable metastatic castrate-resistant prostate cancer (CRPC).
Hoang, David T. +4 more
core +2 more sources
miR186 suppresses prostate cancer progression by targeting Twist1
Oncotarget, 2016 Prostate cancer (PCa) is the second leading cause of cancer-related deaths in north American men, and most its related deaths are due to advanced and metastatic PCa. However, the molecular mechanisms underlying PCa progression are still unclear. Here we use a pair of prostate cell lines P69/M12, which have the same genetic background and the highly ...
Zhao, Xian +9 more
openaire +3 more sources
Destabilization of the TWIST1/E12 complex dimerization following the R154P point-mutation of TWIST1: an in silico approach [PDF]
BMC Structural Biology, 2017 The bHLH transcription factor TWIST1 plays a key role in the embryonic development and in tumorigenesis. Some loss-of-function mutations of the TWIST1 gene have been shown to cause an autosomal dominant craniosynostosis, known as the Saethre-Chotzen syndrome (SCS).
Bouard, Charlotte +7 more
openaire +2 more sources
The FZD7‐TWIST1 axis is responsible for anoikis resistance and tumorigenesis in ovarian carcinoma
Molecular Oncology, 2019 Frizzled family receptor 7 (FZD7), a Wnt signaling receptor, is associated with the maintenance of stem cell properties and cancer progression. FZD7 has emerged as a potential therapeutic target because it is capable of transducing both canonical and ...
Ming Tan +9 more
doaj +1 more source
4 open, 2019 The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with ...
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
TWIST1 a new determinant of epithelial to mesenchymal transition in EGFR mutated lung adenocarcinoma. [PDF]
PLoS ONE, 2012 Metastasis is a multistep process and the main cause of mortality in lung cancer patients. We previously showed that EGFR mutations were associated with a copy number gain at a locus encompassing the TWIST1 gene on chromosome 7.
Karine Pallier +12 more
doaj +1 more source
Twist1 in Human White Adipose Tissue and Obesity [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2011 Twist1 is a transcription factor implicated in the regulation of TNFα signaling and was recently shown to be highly expressed in both human and murine adipose tissue, but its role in obesity is unknown.Our objective was to assess the expression of twist1 in human white adipose tissue (WAT), its relationship to obesity and insulin sensitivity, and how ...
Amanda T, Pettersson +7 more
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2020 ObjectiveDuring hair follicle regeneration, hair follicle stem cells (HFSCs) are regulated by signals from dermal papilla cells (DPCs). Previously we found that Tcf4 could promote the proliferation of DPCs.
Nanlan Yu +8 more
doaj +1 more source