Results 121 to 130 of about 407,697 (279)

The Pseudomonas aeruginosa Cpx system provides a cyclic-di-GMP independent link between cell envelope stress and surface sensing

mBio
Bacteria surveil their cell envelope through a network of envelope stress response systems (ESRs). Beyond regulation of envelope maintenance, ESRs influence expression of a range of virulence traits among pathogenic bacteria. The Cpx two-component system,
Megan R. O'Malley, Hailey N. Dearing, Xuhui Zheng, Alyssa N. Kretschmer, Timothy H.-S. Cho, Tracy L. Raivio, Matthew R. Parsek   +6 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Oscillatory dynamics in a double activator motif [PDF]

, 2011
Biological oscillators, specially those that constitute the circadian clock, have been extensively modelled as coupled feedback loops of positive and negative elements in gene regulatory circuits.
Dasmahapatra, Srinandan
core  

Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis. [PDF]

, 2003
Two-component regulatory signal transduction systems are widely distributed among bacteria and enable the organisms to make coordinated changes in gene expression in response to a variety of environmental stimuli.
Casali, N, Casali, Nicola, Stoker, N G, Kendall, Sharon, Smith, Debbie A, Parish, T, LSHTM, Kendall, S L, Stoker, Neil G, Parish, Tanya, Bancroft, Gregory J, Bancroft, G J, Smith, D A   +12 more
core   +1 more source

Transcriptional pathways across colony biofilm models in the symbiont Vibrio fischeri

mSystems
Beneficial microbial symbionts that are horizontally acquired by their animal hosts undergo a lifestyle transition from free-living in the environment to associating with host tissues.
Jacob A. Vander Griend, Ruth Y. Isenberg, Ketan R. Kotla, Mark J. Mandel   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Comparative Analysis of Wolbachia Genomes Reveals Streamlining and Divergence of Minimalist Two-Component Systems [PDF]

, 2015
Two-component regulatory systems are commonly used by bacteria to coordinate intracellular responses with environmental cues. These systems are composed of functional protein pairs consisting of a sensor histidine kinase and cognate response regulator ...
Christensen, Steen, Serbus, Laura Renee
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Two-component systems in Pseudomonas aeruginosa: Why so many? [PDF]

, 2000
cited By 143International audienceScreening the Pseudomonas aeruginosa genome has led to the identification of the highest number of putative genes encoding two-component regulatory systems of all bacterial genomes sequenced to date (64 and 63 encoding ...
Lazdunski, A., Vincent Méjean, Rodrigue, Agnès, Quentin, Y., Andrée Lazdunski, Méjean, V., Yves Quentin, Foglino, M., Agnès Rodrigue, Maryline Foglino   +9 more
core   +1 more source