Results 1 to 10 of about 373,617 (115)

Compartmentalized cell envelope biosynthesis in Mycobacterium tuberculosis [PDF]

mBio
The inner membrane domain (IMD) is a metabolically active and laterally discrete membrane domain initially discovered in Mycobacterium smegmatis. The IMD correlates both temporally and spatially with the polar cell envelope elongation in M.
Julia Puffal, Ian L. Sparks, James R. Brenner, Xuni Li, John D. Leszyk, Jennifer M. Hayashi, Scott A. Shaffer, Yasu S. Morita   +7 more
doaj   +2 more sources

The NtrYX Two-Component System Regulates the Bacterial Cell Envelope

mBio, 2020
Activity of the NtrYX two-component system has been associated with important processes in diverse bacteria, ranging from symbiosis to nitrogen and energy metabolism.
Kimberly C. Lemmer, François Alberge, Kevin S. Myers, Alice C. Dohnalkova, Ryan E. Schaub, Jonathan D. Lenz, Saheed Imam, Joseph P. Dillard, Daniel R. Noguera, Timothy J. Donohue   +9 more
doaj   +3 more sources

The Pseudomonas aeruginosa Cpx system provides a cyclic-di-GMP independent link between cell envelope stress and surface sensing [PDF]

mBio
Bacteria surveil their cell envelope through a network of envelope stress response systems (ESRs). Beyond regulation of envelope maintenance, ESRs influence expression of a range of virulence traits among pathogenic bacteria. The Cpx two-component system,
Megan R. O'Malley, Hailey N. Dearing, Xuhui Zheng, Alyssa N. Kretschmer, Timothy H.-S. Cho, Tracy L. Raivio, Matthew R. Parsek   +6 more
doaj   +2 more sources

Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth.

PLoS Genetics, 2021
The cell envelope is essential for viability in all domains of life. It retains enzymes and substrates within a confined space while providing a protective barrier to the external environment. Destabilising the envelope of bacterial pathogens is a common
Emily C A Goodall, Georgia L Isom, Jessica L Rooke, Karthik Pullela, Christopher Icke, Zihao Yang, Gabriela Boelter, Alun Jones, Isabel Warner, Rochelle Da Costa, Bing Zhang, James Rae, Wee Boon Tan, Matthias Winkle, Antoine Delhaye, Eva Heinz, Jean-Francois Collet, Adam F Cunningham, Mark A Blaskovich, Robert G Parton, Jeff A Cole, Manuel Banzhaf, Shu-Sin Chng, Waldemar Vollmer, Jack A Bryant, Ian R Henderson   +25 more
doaj   +1 more source

Detection of Mycobacterium avium Subspecies paratuberculosis (MAP) Microorganisms Using Antigenic MAP Cell Envelope Proteins

Frontiers in Veterinary Science, 2021
Cell envelope proteins from Mycobacterium avium subspecies paratuberculosis (MAP) that are antigenically distinct from closely related mycobacterial species are potentially useful for Johne's Disease (JD) diagnosis.
Shanmugasundaram Karuppusamy, Lucy Mutharia, David Kelton, Brandon Plattner, Sanjay Mallikarjunappa, Niel Karrow, Gordon Kirby   +6 more
doaj   +1 more source

A Barrier to Entry: Examining the Bacterial Outer Membrane and Antibiotic Resistance

Applied Sciences, 2023
Gram-negative bacteria can resist antibiotics by changing the permeability via their outer membrane. These bacteria have a complex cell envelope that incorporates an outer membrane separating the periplasm from the external environment.
Ishan Ghai
doaj   +1 more source

A Biological Signature for the Inhibition of Outer Membrane Lipoprotein Biogenesis

mBio, 2022
The outer membrane (OM) of Gram-negative bacteria is an essential organelle that acts as a formidable barrier to antibiotics. Increasingly prevalent resistance to existing drugs has exacerbated the need for antibiotic discovery efforts targeting the OM ...
Kelly M. Lehman, Hannah C. Smith, Marcin Grabowicz   +2 more
doaj   +1 more source

Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis

mBio, 2022
Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The basis for this conditional drug susceptibility remains undefined.
Joshua M. Thiede, Nicholas A. Dillon, Michael D. Howe, Ranee Aflakpui, Samuel J. Modlin, Sven E. Hoffner, Faramarz Valafar, Yusuke Minato, Anthony D. Baughn   +8 more
doaj   +1 more source

Crosstalk between Yeast Cell Plasma Membrane Ergosterol Content and Cell Wall Stiffness under Acetic Acid Stress Involving Pdr18

Journal of Fungi, 2022
Acetic acid is a major inhibitory compound in several industrial bioprocesses, in particular in lignocellulosic yeast biorefineries. Cell envelope remodeling, involving cell wall and plasma membrane composition, structure and function, is among the ...
Ricardo A. Ribeiro, Cláudia P. Godinho, Miguel V. Vitorino, Tiago T. Robalo, Fábio Fernandes, Mário S. Rodrigues, Isabel Sá-Correia   +6 more
doaj   +1 more source

Viral Ejection Proteins: Mosaically Conserved, Conformational Gymnasts

Microorganisms, 2022
Bacterial viruses (or bacteriophages) have developed formidable ways to deliver their genetic information inside bacteria, overcoming the complexity of the bacterial-cell envelope. In short-tailed phages of the Podoviridae superfamily, genome ejection is
Nicholas A. Swanson, Chun-Feng D. Hou, Gino Cingolani   +2 more
doaj   +1 more source