Results 251 to 260 of about 407,697 (279)

Role of two-component regulatory systems in the virulence of Streptococcus suis

Microbiological Research, 2018
Streptococcus suis is an important zoonotic pathogen that causes severe infections and great economic losses worldwide. Understanding how this pathogen senses and responds to environmental signals during the infectious process can offer insight into its pathogenesis and may be helpful in the development of drug targets. Two-component regulatory systems
Weicheng Bei, Chengkun Zheng, Xiaohui Zhou   +2 more
exaly   +3 more sources

Role of two‐component regulatory systems in intracellular survival of Mycobacterium tuberculosis [PDF]

Journal of Cellular Biochemistry, 2019
The typical two-component regulatory systems (TCSs), consisting of response regulator and histidine kinase, play a central role in survival of pathogenic bacteria under stress conditions such as nutrient starvation, hypoxia, and nitrosative stress.
Yue Li, Xue Li, Jianping Xie
exaly   +3 more sources

Elucidation of Regulatory Modes for Five Two-Component Systems in Escherichia coli Reveals Novel Relationships [PDF]

MSystems, 2020
Escherichia coli uses two-component systems (TCSs) to respond to environmental signals. TCSs affect gene expression and are parts of E. coli’s global transcriptional regulatory network (TRN). Here, we identified the regulons of five TCSs in E.
Yara Seif, Kumari Sonal Choudhary, Richard Szubin   +2 more
exaly   +3 more sources

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Two-Component Regulatory Systems

2014
Originally characterized for nitrogen regulation (NtrB-NtrC), chemotaxis (CheA-CheY-CheB), osmoregulation (EnvZ-OmpR), and regulation of phosphate uptake (PhoR-PhoB) in Escherichia coli and Salmonella typhimurium, the family of two-component systems has rapidly expanded, and new examples continue to emerge.
Tarek Msadek, Frank Kunst, Georges Rapoport   +2 more
openaire   +1 more source

Substituted Salicylanilides as Inhibitors of Two-Component Regulatory Systems in Bacteria

Journal of Medicinal Chemistry, 1998
A new class of inhibitors of the two-component regulatory systems (TCS) of bacteria was discovered based on the salicylanilide screening hits, closantel (1) and tetrachlorosalicylanilide (9). A systematic SAR study versus a model TCS, KinA/Spo0F, demonstrated the importance of electron-attracting substituents in the salicyloyl ring and hydrophobic ...
M J, Macielag, J P, Demers, S A, Fraga-Spano, D J, Hlasta, S G, Johnson, R M, Kanojia, R K, Russell, Z, Sui, M A, Weidner-Wells, H, Werblood, B D, Foleno, R M, Goldschmidt, M J, Loeloff, G C, Webb, J F, Barrett   +14 more
openaire   +2 more sources

The role of two-component regulatory system in β-lactam antibiotics resistance

Microbiological Research, 2018
The irrational use of antibiotics in agriculture and in the medical field has led to a variety of pathogenic microorganisms that produce drug resistance and even multidrug resistance. B-lactam is one of the most widely used antibiotics to treat infectious diseases.
Xiaohui Zhou, Gu Dan
exaly   +3 more sources

Measuring the Activities of Two-Component Regulatory System Phosphatases

2018
Two-component regulatory systems (TCSs) are used for signal transduction by organisms from all three phylogenetic domains of the living world. TCSs use transient protein phosphorylation and dephosphorylation reactions to convert stimuli into appropriate responses to changing environmental conditions.
Robert B, Bourret, Ruth E, Silversmith
openaire   +2 more sources

Bacterial Two-Component Regulatory Systems

1998
Two-component regulation involves a stimulus-sensitive sensor (histidine protein kinase) that controls the phosphorylation state, and therefore the activity, of its cognate response regulator. Specific two-component systems regulate bacterial response to a wide range of environmental conditions, and many variations on the basic theme have been ...
openaire   +1 more source

INVESTIGATING CHARACTERISTICS OF BACTERIAL TWO-COMPONENT REGULATORY SYSTEMS

2023
Two-component systems (TCS) are a major means by which microorganisms interact with their environments. In a typical TCS, a sensor kinase senses an environmental stimulus and uses autophosphorylation to translate the stimulus into a chemical message.
openaire   +1 more source

Proteomic identification of a two-component regulatory system in Pseudoalteromonas haloplanktis TAC125

Extremophiles, 2006
The capability of microorganisms to utilize different carbohydrates as energy source reflects the availability of these substrates in their habitat. Investigation of the proteins involved in carbohydrate usage, in parallel with analysis of their expression, is then likely to provide information on the interaction between microorganisms and their ...
PAPA, ROSANNA, GLAGLA S, DANCHIN A, SCHWEDER T, MARINO, GENNARO, DUILIO, ANGELA   +5 more
openaire   +4 more sources