Results 161 to 170 of about 39,562,488 (191)

Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2

Pflügers Archiv - European Journal of Physiology, 2013
THIK-2 belongs to the 'silent' channels of the two-pore-domain potassium channel family. It is highly expressed in many nuclei of the brain but has so far resisted all attempts at functional expression. THIK-2 has a highly conserved 19-amino-acid region in its N terminus (residues 6-24 in the rat orthologue) that is missing in the closely related ...
Vijay, Renigunta, Xinle, Zou, Stefan, Kling, Günter, Schlichthörl, Jürgen, Daut   +4 more
openaire   +2 more sources

Investigating the Role of Two-Pore Channel 2 (TPC2) in Zebrafish Neuromuscular Development

2020
In this chapter, the authors discuss the techniques used when investigating the role of Two-Pore Channel 2 (TPC2) in zebrafish neuromuscular development. The role of TPC2 in the differentiation of slow muscle cells and PMNs in intact zebrafish embryos has been investigated using various approaches.
Webb, Sarah Elizabeth LIFS, Kelu, Jeffrey Jenkin, Miller, Andrew Leitch   +2 more
openaire   +2 more sources

Ca²⁺ signals, NAADP and two‐pore channels: role in cellular differentiation

Acta Physiologica, 2014
AbstractCa2+ signals regulate a wide range of physiological processes. Intracellular Ca2+ stores can be mobilized in response to extracellular stimuli via a range of signal transduction mechanisms, often involving recruitment of diffusible second messenger molecules.
J, Parrington, R, Tunn
openaire   +2 more sources

Cardiovascular pharmacology of K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels

Naunyn-Schmiedeberg's Archives of Pharmacology, 2018
K2P17.1 (TASK-4, TALK-2) potassium channels are expressed in the heart and represent potential targets for pharmacological management of atrial and ventricular arrhythmias. Reduced K2P17.1 expression was found in atria and ventricles of heart failure (HF) patients.
Ingo, Staudacher, Claudius, Illg, Sam, Chai, Isabelle, Deschenes, Sebastian, Seehausen, Dominik, Gramlich, Mara Elena, Müller, Teresa, Wieder, Ann-Kathrin, Rahm, Christina, Mayer, Patrick A, Schweizer, Hugo A, Katus, Dierk, Thomas   +12 more
openaire   +2 more sources

Characterization of two-pore channel 2 by nuclear membrane electrophysiology

2015
Conference Theme: Molecular and Cellular Mechanisms in Health and ...
Lee, SK, Cheung, KH, Cheng, WH, Tong, CK
openaire   +1 more source

Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

Autophagy, 2022
Weidong Pan, Ju-Xian Song, Chun Kit Benjamin Tong   +2 more
exaly  

Insight into essential channel effect of pore structures and hydrogen bonds on the solvent extraction of oily sludge

Journal of Hazardous Materials, 2020
Shuhai Guo, Jian Dong, Dong Liu
exaly  

Interactions of the Kv1.1 Channel with Peptide Pore Blockers: A Fluorescent Analysis on Mammalian Cells

Membranes, 2023
Mikhail Kirpichnikov, Sergey Yakimov, Alexey Feofanov   +2 more
exaly  

Novel chemical tools for the modulation of two pore channel 2

2020
openaire   +1 more source

Identification and functional characterization of the Piezo1 channel pore domain

Journal of Biological Chemistry, 2021
Elena D Nosyreva, Ruhma Syeda
exaly