Results 151 to 160 of about 23,757 (245)

Enterococcus faecalis Extracellular Vesicles Deliver the Bacterial GTPase Obg to Hijack mTOR Signalling in Hepatocellular Carcinoma

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
E. faecalis is enriched in HCC tissue and can promote liver tumourigenesis by activating mTOR signalling pathway. Obg derived from E. faecalis extracellular vesicles (EVs) is a GTPase physically interacts with mTOR, and acts as an interkingdom activator of mTOR. EF‐Obg expression level in HCC tissue correlates with poor prognosis in HCC patients.
Ning Ma   +18 more
wiley   +1 more source

Development and Validation of Nomogram Predicting Survival in Resectable Gallbladder Cancer

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, Volume 33, Issue 6, Page 454-462, June 2026.
Patkar and colleagues developed and internally validated a nomogram predicting overall survival after resection of gallbladder cancer using a large cohort of 1045 patients. The model demonstrated good accuracy and discriminative capacity, and stratified patients into prognostically distinct risk groups, supporting more objective selection and ...
Shraddha Patkar   +9 more
wiley   +1 more source

Temporal Biomolecular Processes Underlying Recovery Following 90% Partial Hepatectomy: A Proteomics Study in Rats

open access: yesLiver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT Background Post‐hepatectomy liver failure (PHLF) remains a limitation in the surgical treatment of liver cancer. The 90% partial hepatectomy (PH) rat model reliably induces biochemical PHLF and high mortality, providing a unique platform for identifying molecular pathways necessary for successful liver regeneration.
Andrea Lund   +4 more
wiley   +1 more source

Bioartificial Livers Developed From Gene‐Edited Pig Hepatocyte Organoids Improve Amino Acid and Lipid Profiles in the Plasma of Patients With Liver Failure

open access: yesMedComm, Volume 7, Issue 6, June 2026.
A bioartificial liver (BAL) integrating GGTA1‐knockout porcine hepatocytes and R‐spondin1‐overexpressing endothelial organoids was tested using plasma from patients with acute‐on‐chronic liver failure (ACLF). The BAL system actively modulates amino acid and lipid metabolism, enhances detoxification, partially restores overall metabolic balance, and ...
Yuting He   +8 more
wiley   +1 more source

진행성 담낭암에 대한 Radical Transverse Hepatectomy

open access: yes, 1996
Gallbladder carcinoma is relatively rare and generally has a poor prognosis in spite of various treatment modalities. There are no symptoms in the early stages of this tumors, and it is already too advanced to resect curatively when diagnosed.
김, 욱환   +3 more
core  

Chinese Registry on Transjugular Intrahepatic Portosystemic Shunts (CN‐TIPS): Protocol for a Registry‐Based, Prospective Prognostic Study

open access: yesPortal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 160-169, June 2026.
CN‐TIPS is a nationwide, multicenter prospective registry that will enroll 10,000 adults with portal hypertension undergoing transjugular intrahepatic portosystemic shunt in China, integrating perioperative clinical and hemodynamic metrics with standardized imaging (including computational modeling in a dedicated subcohort) and multi‐omics biospecimens,
Yi Xiang   +20 more
wiley   +1 more source

Liver resection for patients with hepatocellular carcinoma and portal hypertension

open access: yesZhongguo aizheng zazhi, 2014
Background and purpose: The proportion of hepatocellular carcinoma (HCC) patients with cirrhosis and portal hypertension (PHT) is high. PHT may increase the risk of hemorrhage and liver failure.
张培军   +5 more
doaj  

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