Results 141 to 150 of about 23,757 (245)

Laparoscopic Delivery of a MnO2‐P‐ICG Patch for Photodynamic Therapy and NK Cell‐Driven Immunotherapy in Hepatocellular Carcinoma

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study proposes a flexible MnO2‐P‐ICG nanofiber patch for laparoscopic treatment of liver tumors. The patch alleviates tumor hypoxia and induces photodynamic therapy (PDT) triggered immunogenic cell death, thereby activating the cGAS‐STING pathway and, in synergy with pachymaran, promoting NK cell–mediated innate immunity. This synergistic strategy
Jie Lin, Haoqi Pan, Ke Wu, Junjie Nan, Jinyao Dai, Yushun Chang, Hao Shen, Qingxuan Ye, Haowen Lu, Yuxuan Shen, Boqiang Liu, Ming Wu, Jicheng Yu, Xiujun Cai, Dong Cen   +14 more
wiley   +1 more source

Characterization and prevention of the “small-for-size” syndrome in a porcine model of hepatic transplant [PDF]

, 2011
The hypothesis of this doctoral thesis is two-fold: 1. Excessive portal vein flow is present immediately after portal reperfusion in the recipient and is the instigating factors in a series of events that ultimately lead to the development of “small-for ...
Hessheimer, Amelia Judith
core  

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

Glutathione peroxidase 3 preserves hepatocyte mitochondrial quality control to enhance macrophage pro‐regenerative phenotype during liver regeneration

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
(1) GPX3 inhibits VDAC1 oligomerisation by directly binding to it. (2) The loss of GPX3 leads to VDAC1 oligomerisation, resulting in dysregulation of mitochondrial quality control, characterised by enhanced fission, weakened fusion and impaired autophagy.
Yuechen Wang, Jian Xu, Zeyu Zhu, Ye Zhang, Haoran Hu, Yiyun Gao, Yuting Tao, Feifan Yao, Suiqing Zhou, Weizhe Zhong, Zhuqing Rao, Haoming Zhou, Xuehao Wang   +12 more
wiley   +1 more source

Tuning the Affinity of Chimeric Antigen Receptors Enhances the Function of Human Engineered Regulatory T Cells

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Affinity tuning of anti‐HLA‐A2 CARs reveals that lower‐affinity CAR‐Tregs exhibit reduced avidity and enhanced serial engagement, leading to increased activation and trogocytosis. These properties promote improved tissue infiltration, persistence, and survival in vivo, demonstrating that optimizing receptor–antigen dynamics enhances the therapeutic ...
Ada Sera Kurt, Marwa Elgosbi, Elisavet Kodela, Emmanuelle Landmann, Paula Ruiz, Yoh Zen, Jorge Torres‐Yaguana, Alexander Puttick, Quisha Bustamante, Minahil Sharjeel, Hannan Murshid, Marc Martinez‐Llordella, Alberto Sanchez‐Fueyo   +12 more
wiley   +1 more source

P-248 Futility and utility of two-stage hepatectomy

, 2019
Meeting abstract in the European-Society-for-Medical-Oncology (ESMO) 21st World Congress on Gastrointestinal Cancer.
Cunha, M., Barros, I., Marreiros, A., Martins, A., Pinto Marques, H.   +4 more
openaire   +1 more source

Operative Results and Oncologic Outcomes of Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Versus Two-Stage Hepatectomy (TSH) in Patients with Unresectable Colorectal Liver Metastases: A Systematic Review and Meta-Analysis

, 2018
Background: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has recently emerged as a treatment choice for patients with colorectal liver metastases (CLM) and inadequate future liver remnant (FLR).
Papalampros, A., Kostakis, I.D., Pawlik, T.M., Dimitroulis, D., Beal, E.W., Felekouras, E., Moris, D., Tsilimigras, D.I., Ronnekleiv-Kelly, S.   +8 more
core  

INTENSIVE CARE OF PATIENT WITH TWO-STAGE LIVER TRANSPLANTATION- CASE REPORT

Zdravniški Vestnik, 2014
A two-stage liver transplantation is a procedure where total hepatectomy is followed by temporary anastomosis of the vena portae with the inferior vena cava. It was shown to be successful as a bridge procedure in patients who are awaiting emergency liver
Rade Stanić, Alja Skrt
doaj  

2 stage hepatectomy with ALPPS technique (liver splitting association) with ligature portal for hepatectomy in 2 times). Experience and initial results of the Regional Hospital of Talca

, 2018
Introduction: Postoperative liver failure (POLF) is a relevant cause of morbimortality after liver surgery. An insufficient future liver remnant (FLR) is one of the main causes of POLF.
Vergara A., Gloria, Vega, Rodrigo, Santelices B., Marcelo, Sepúlveda D., Guillermo, Araya M., Hernán, Tapia V., Álvaro, Muñoz-Castro, César A.   +6 more
core  

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source