Results 61 to 70 of about 2,618 (150)
Molecular Oncology, Volume 20, Issue 8, Page 1913-1932, August 2026.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Case Reports in Ophthalmology, 2021 Mitochondrial neurogastrointestinal encephalopathy disease (MNGIE) is a rare autosomal recessive condition characterized by gastrointestinal dysmotility, external ophthalmoplegia, leukoencephalopathy, and sensorimotor neuropathy.
Armin Farahvash +2 more
doaj +1 more source
In-depth analysis of polyclonal antibodies towards TYMP.
, 2012 The three polyclonal antibodies from the separate immunizations of a recombinant fragment of TYMP were mapped to reveal the major epitopes, which are highlighted in different colors (Bead array).
John Löfblom (110216) +4 more
core +1 more source
Hearing Loss in Adults With Diabetes and Prediabetes: A Systematic Review and Meta‐Analysis
Diabetes/Metabolism Research and Reviews, Volume 42, Issue 5, July 2026.ABSTRACT Diabetes impairs hearing through microvascular damage and neuropathy, yet the prevalence of moderate‐to‐severe hearing loss (≥ 40 dB HL) remains inadequately explored. Variations by age, diabetes duration, and socioeconomic factors are inadequately characterised. This systematic review quantified the prevalence and comparative risk of moderate‐
Mehwish Nisar +4 more
wiley +1 more source
Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy
MedComm, Volume 7, Issue 7, July 2026.Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu +5 more
wiley +1 more source
Disrupting Tymp-Mediated Pathways to Block Lymph Node Metastasis in Ovarian Cancer [PDF]
Historically, ovarian cancer (OC) was thought to metastasize by surface-to-surface spread, but recent developments have yielded a new understanding of the paths of metastatic spread.
Bayraktar, Emine
core +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, Volume 13, Issue 35, 24 June 2026.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
EMBO Molecular Medicine, 2015 Mitochondrial disorders are a group of highly invalidating human conditions for which effective treatment is currently unavailable and characterized by faulty energy supply due to defective oxidative phosphorylation (OXPHOS).
Ivano Di Meo +2 more
doaj +1 more source
Epilepsia, Volume 67, Issue 6, Page 3185-3198, June 2026.Abstract Objective This study was undertaken to investigate the molecular consequences of pathogenic variants in the SMC1A gene—particularly those associated with developmental and epileptic encephalopathy (DEE85)—and to evaluate the therapeutic potential of ataluren in restoring SMC1A function and mitigating disease‐related transcriptomic and genomic ...
Maddalena Di Nardo +7 more
wiley +1 more source
iMetaOmics, Volume 3, Issue 2, June 2026.Integrating multiplexed immunofluorescence, animal models, and clinical samples, our single‐cell and spatial atlas maps tumor microenvironment evolution during bladder cancer (BCa) progression. We reveal that stemness‐associated tumor cells (SDC1+), POSTN+ myofibroblastic cancer‐associated fibroblasts (mCAFs), and immunosuppressive monocytic myeloid ...
Ting Liang +13 more
wiley +1 more source