Results 51 to 60 of about 2,618 (150)

Compound heterozygous mutations of TYMP as underlying causes of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)

, 2018
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), an autosomal recessive multiorgan disease, frequently associated with mutations in the thymidine phosphorylase (TYMP) gene.
최병옥
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Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways [PDF]

, 2015
Background High levels of thymidine kinase 1 (TK1) and thymidine phosphorylase (TYMP) are key molecular targets by thymidine therapeutics in cancer treatment.
Haijuan Liu, Zhang, Zhiwei, Zhou, Qibing, Wei, Qiong, Liu, Haijuan, Dejun Zhang, Zhou, Honghao, Honghao Zhou, Qibing Zhou, Zhiwei Zhang, Qiong Wei, Zhang, Dejun   +11 more
core   +2 more sources

Serum‐Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity‐Linked Signatures

Allergy, EarlyView.
This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial enriched severity footprint linked to LDH‐associated tissue injury and Th2/Th22 inflammation.
Jag S. Lally, Takeshi Yoshida, Shan Gao, Xueya Cai, Donald Y. M. Leung, Lisa A. Beck, Anna De Benedetto   +6 more
wiley   +1 more source

Impact of thymidine phosphorylase and CD163 expression on prognosis in stage II colorectal cancer

, 2022
BACKGROUND: Tumor-associated macrophages (TAM) are known to facilitate colorectal cancer (CRC) growth. High macrophage infiltration in thymidine phosphorylase (TYMP) expressing CRC may correspond to poor prognosis. The prognostic impact of the expression
Wettergren, Yvonne, Wettergren, Yvonne,, Bexe-Lindskog, Elinor,, Szeponik, Louis, Yrlid, Ulf, Szeponik, Louis,, Kaidi, Donia, Kaidi, Donia,, Bexe Lindskog, Elinor, Yrlid, Ulf,   +9 more
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Liver as a source for thymidine phosphorylase replacement in mitochondrial neurogastrointestinal encephalomyopathy.

PLoS ONE, 2014
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive mitochondrial disease associated with mutations in the nuclear TYMP gene.
Elisa Boschetti, Roberto D'Alessandro, Francesca Bianco, Valerio Carelli, Giovanna Cenacchi, Antonio D Pinna, Massimo Del Gaudio, Rita Rinaldi, Vincenzo Stanghellini, Loris Pironi, Kerry Rhoden, Vitaliano Tugnoli, Carlo Casali, Roberto De Giorgio   +13 more
doaj   +1 more source

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source

Figure S4 from Capecitabine Efficacy Is Correlated with TYMP and RB1 Expression in PDX Established from Triple-Negative Breast Cancers

, 2018
A) Immunohistochemistry analysis of HER2, Rb and TYMP (20X) in the HBCx-73 PDX B) response to trastuzumab and capecitabine in the HBCx-73 ...
Sergio Roman-Roman (413776), Sophie Château-Joubert (11410163), Ahmed Dahmani (10846166), Florence Coussy (8939912), Ivan Bièche (3492), Elisabetta Marangoni (655592), Pierre Foidart (15012042), Cécile Laurent (501717), Anne Vincent-Salomon (29230), Agnès Noel (3466064), Sophie Vacher (233965), Nor Eddine Sounni (4506502), Didier Decaudin (83688), Martine Piccart (215602), David Gentien (15012039), Jean-Luc Servely (499101), Rania El-Botty (11410160), Fabien Reyal (53750), Audrey Rapinat (14901939), Franck Assayag (3157383), Elodie Montaudon (10846172), Justine Fleury (15012036), Marick Lae (86533), Ludmilla de Plater (15012033), Fariba Nemati (405824)   +24 more
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BLIMP‐1 and CD39 expression define human effector memory regulatory T cells in blood and recall responses to viruses

Immunology &Cell Biology, Volume 104, Issue 8, Page 757-767, September 2026.
This study found that BLIMP‐1 is highly expressed in activated effector/memory human regulatory T cells, especially CD39+ Tregs, where it is associated with increased IL‐10 production and a conserved phenotype across blood and lung tissues during immune responses such as SARS‐CoV‐2 infection.
Chansavath Phetsouphanh, Laura Cook, Katherine J. L. Jackson, Deirdre Cuff, Vera Klemm, Bikash Manandhar, Denise C. Hsu, Yin Xu, John J. Zaunders, Anthony D. Kelleher, Nabila Seddiki   +10 more
wiley   +1 more source

Figure S3 from Capecitabine Efficacy Is Correlated with TYMP and RB1 Expression in PDX Established from Triple-Negative Breast Cancers

, 2018
Boxplot of the expression of genes encoding proteins involved in capecitabine metabolism (TYMP, TYMS, TK1, DPYD) and cell-cycle control (RB1, CDKN2A, CCND1).
Sergio Roman-Roman (413776), Sophie Château-Joubert (11410163), Ahmed Dahmani (10846166), Florence Coussy (8939912), Ivan Bièche (3492), Elisabetta Marangoni (655592), Pierre Foidart (15012042), Cécile Laurent (501717), Anne Vincent-Salomon (29230), Agnès Noel (3466064), Sophie Vacher (233965), Nor Eddine Sounni (4506502), Didier Decaudin (83688), Martine Piccart (215602), David Gentien (15012039), Jean-Luc Servely (499101), Rania El-Botty (11410160), Fabien Reyal (53750), Audrey Rapinat (14901939), Franck Assayag (3157383), Elodie Montaudon (10846172), Justine Fleury (15012036), Marick Lae (86533), Ludmilla de Plater (15012033), Fariba Nemati (405824)   +24 more
core   +1 more source

Role of Thymidine Phosphorylase in Type 2 Diabetes-Associated High-Risk of Thrombosis [PDF]

, 2021
Cardiovascular diseases (CVDs), such as ischemic heart disease and stroke, are the leading causes of death globally that disproportionally affects patients with type 2 diabetes mellitus (T2DM) at a 2-4-fold rate compared to non-diabetic patients.
Belcher, Adam
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