Results 31 to 40 of about 2,618 (150)

Targeting thymidine phosphorylase alleviates resistance to dendritic cell immunotherapy in colorectal cancer and promotes antitumor immunity

Frontiers in Immunology, 2022
T-cell exhaustion plays a pivotal role in the resistance of microsatellite-stable colorectal cancer (CRC) to immunotherapy. Identifying and targeting T-cell exhaustion-activating mechanisms is a promising strategy to augment the effects of immunotherapy.
Ankush Paladhi, Samrat Daripa, Indrani Mondal, Sumit Kumar Hira   +3 more
doaj   +1 more source

Influence of TYMP Polymorphism on Clinical Outcomes of Colorectal Cancer Patients Received Adjuvant Chemotherapy After R0 Resection

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the association between thymidine phosphorylase(TYMP) polymorphism and clinical outcomes of colorectal cancer(CRC) patients received adjuvant chemotherapy after R0 resection.
ZHANG Yu, HOU Yanhua, ZHANG Dezhi
doaj   +1 more source

Capecitabine efficacy is correlated with TYMP and RB expression in PDX established from triple-negative breast cancers. [PDF]

, 2018
peer reviewedPURPOSE: triple-negative breast cancer (TNBC) patients with residual disease after neoadjuvant chemotherapy have a poor outcome. We developed patient-derived xenografts (PDX) from residual tumors to identify efficient chemotherapies and ...
Sophie Château-Joubert, Rapinat, Audrey, Vacher, Sophie, Nemati, Fariba, Audrey Rapinat, Servely, Jean-Luc, Fleury, Justine, Laurent, Cecile, Cécile Laurent, Fariba Nemati, Vincent-Salomon, Anne, Franck Assayag, Justine Fleury, El Botty, Rania, Pierre Foidart, Elisabetta Marangoni, Dahmani, Ahmed, Sounni, Nor Eddine, Montaudon, Elodie, Florence Coussy, Ivan Bièche, Fabien Reyal, Jean-Luc Servely, Rania El-Botty, Assayag, Franck, Chateau-Joubert, Sophie, Gentien, David, Martine Piccart, Coussy, Florence, Salomon, Anne, Servely, Jean Luc, Ludmilla de Plater, David Gentien, Roman-Roman, Sergio, Lae, Marick, de Plater, Ludmilla, Sergio Roman-Roman, Bieche, Ivan, Foidart, Pierre, Anne Vincent-Salomon, Agnès Noel, Marangoni, Elisabetta, Piccart, Martine, Nor Eddine Sounni, Noël, Agnès, El-Botty, Rania, Sophie Vacher, Didier Decaudin, Elodie Montaudon, Piccard, Martine, Ahmed Dahmani, Reyal, Fabien, Decaudin, Didier, Marick Lae   +53 more
core   +2 more sources

STING-driven interferon signaling triggers metabolic alterations in pancreas cancer cells visualized by [ 18 F]FLT PET imaging [PDF]

, 2021
Type I interferons (IFNs) are critical effectors of emerging cancer immunotherapies designed to activate pattern recognition receptors (PRRs). A challenge in the clinical translation of these agents is the lack of noninvasive pharmacodynamic biomarkers ...
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core   +3 more sources

sj-docx-1-tct-10.1177_15330338231194555 - Supplemental material for Identifying TYMP as an Immune Prognostic Marker in Clear Cell Renal Cell Carcinoma

, 2023
Supplemental material, sj-docx-1-tct-10.1177_15330338231194555 for Identifying TYMP as an Immune Prognostic Marker in Clear Cell Renal Cell Carcinoma by Shao-An Chen, Jun-Peng Zhang, Ning Wang and Ji Chen in Technology in Cancer Research ...
Shao-An Chen (17546483), Ning Wang (108353), Jun-Peng Zhang (12048624), Ji Chen (69329)   +3 more
core   +1 more source

Clinical and molecular characterization of a patient with mitochondrial Neurogastrointestinal Encephalomyopathy

BMC Gastroenterology, 2020
Background Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disorder caused by mutations in TYMP gene, encoding nuclear thymidine phosphorylase (TP).
Parham Habibzadeh, Mohammad Silawi, Hassan Dastsooz, Shima Bahramjahan, Shahrokh Ezzatzadegan Jahromi, Vahid Reza Ostovan, Majid Yavarian, Mohammad Mofatteh, Mohammad Ali Faghihi   +8 more
doaj   +1 more source

Rs11479 in Thymidine Phosphorylase Associated with Prognosis of Patients with Colorectal Cancer Who Received Capecitabine-Based Adjuvant Chemotherapy

Pharmacogenomics and Personalized Medicine, 2023
Xiongjie Jia,* Tao Zhang,* Junjie Sun, Hengxue Lin, Tianliang Bai, Yating Qiao, Yaxin Li, Gang Li, Guicun Li, Xinyu Peng, Aimin Zhang Department of Gastrointestinal Surgery, Affiliated Hospital of Hebei University, Baoding, People’s Republic of ...
Jia X, Zhang T, Sun J, Lin H, Bai T, Qiao Y, Li Y, Li G, Li G, Peng X, Zhang A   +10 more
doaj  

Integrating metabolomics and network pharmacology to assess the effects of quercetin on lung inflammatory injury induced by human respiratory syncytial virus

Scientific Reports, 2023
Quercetin (QR) has significant anti-respiratory syncytial virus (RSV) effects. However, its therapeutic mechanism has not been thoroughly explored. In this study, a lung inflammatory injury model caused by RSV was established in mice.
Ya-Lei Sun, Pei-Pei Zhao, Cheng-Bi Zhu, Ming-Chen Jiang, Xin-Min Li, Jia-Lei Tao, Chan-Chan Hu, Bin Yuan   +7 more
doaj   +1 more source

TYMP mRNA transcription in a panel of healthy human tissues.

, 2014
The amount of TYMP mRNA has been reported ± SD. Bone marrow was used as a calibrator tissue. TYMP mRNA expression did not vary significantly in bone marrow, liver, and duodenal mucosa. No TYMP transcript was found in skeletal muscle.
Roberto De Giorgio (552509), Roberto D’Alessandro (560283), Giovanna Cenacchi (337237), Vincenzo Stanghellini (560288), Vitaliano Tugnoli (560291), Valerio Carelli (24588), Loris Pironi (560289), Francesca Bianco (560284), Massimo Del Gaudio (560286), Elisa Boschetti (560282), Antonio D. Pinna (560285), Rita Rinaldi (560287), Carlo Casali (560292), Kerry Rhoden (560290)   +13 more
core   +1 more source

Clinicopathology and Diagnosis Delay in a 40-Year-Old with Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE)

Case Reports in Gastroenterology, 2020
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive and fatal multisystem metabolic disorder. It presents with wide-ranging gastrointestinal and neurologic symptoms.
Antonios Tawk, Mohammed Hussein Kamarreddine, Mona Dagher, Ghadi Abboud, Mohamad Chams, Fatmeh Ghandour-Hajj, Mounir Khoury, Said Farhat   +7 more
doaj   +1 more source