Results 161 to 170 of about 854,739 (262)

Total Synthesis of (−)‐Vescalagin, the Iconic Member of the C‐Glucosidic Ellagitannin Family

Chemistry – A European Journal, EarlyView.
This communication describes the first total synthesis of the 2,3,5‐O‐(S,R)‐NonaHydroxyTriPhenoylated (NHTP) and 4,6‐O‐(S)‐HexaHydroxyDiPhenoylated (HHDP) C‐glucosidic ellagitannin (−)‐vescalagin and that of its C‐1 epimer (−)‐castalagin. The key steps of these syntheses were performed and sequenced by getting inspiration from the manner through which ...
Romain Larrieu, Anaëlle Cornu, Laurent Pouységu, Denis Deffieux, Stéphane Quideau   +4 more
wiley   +1 more source

The Status and Influencing Factors of Health Behavior Self-Management in Children With Type 1 Diabetes Mellitus: A Cross-Sectional Study. [PDF]

Health Sci Rep
Yang JX, Liu Y, Cao SY, Wang GY, Zhou HM, Wang YY, Ai ZS.   +6 more
europepmc   +1 more source

Impact of Model‐Informed Drug Development on Drug Development Cycle Times and Clinical Trial Cost

Clinical Pharmacology &Therapeutics, EarlyView.
Model‐informed drug development (MIDD) integrates data to quantify benefit/risk informing objective drug discovery and development decisions. An additional critical benefit of MIDD is postulated to be improvement in trial and program efficiencies. While the application of MIDD has grown, there have been no clear examples across programs to demonstrate ...
Vaishali Sahasrabudhe, Timothy Nicholas, Gianluca Nucci, Cynthia J Musante, Brian Corrigan   +4 more
wiley   +1 more source

New marker for the detection of pre-retinopathy in patients with type 1 diabetes mellitus: systemic immuno-inflammation index. [PDF]

BMC Ophthalmol
Kahraman HG, Güven YZ, Akay F, Üzüm Y, Aysin M.   +4 more
europepmc   +1 more source

Prenatal and Early Childhood Exposure to Antibiotics or Gastric Acid Inhibitors and Increased Risk of Epilepsy: A Nationwide Population‐Based Study

Clinical Pharmacology &Therapeutics, EarlyView.
Over 10 million children in the world have epilepsy, with an unknown cause in half of the cases. The gut microbiome has been associated with various neurological disorders, and certain drugs greatly disturb the microbiome. Our aim was to study the association of prenatal and childhood exposure (before the age of two) to antibiotics, proton pump ...
Unnur Gudnadottir, Ronny Wickström, Anna Gunnerbeck, Stefanie Prast‐Nielsen, Nele Brusselaers   +4 more
wiley   +1 more source

Assessing Implantation Sites for Pancreatic Islet Cell Transplantation: Implications for Type 1 Diabetes Mellitus Treatment. [PDF]

Bioengineering (Basel)
Gabriel Silvério Scholl V, Todeschini Justus L, Girotto OS, Karine Pasqual K, Garcia MHH, da Silva Petronio FG, de Moraes AF, Maria Barbalho S, Araújo AC, Fornari Laurindo L, Camargo CP, Miglino MA.   +11 more
europepmc   +1 more source

A Genetic Twist: Cytologic Evaluation of Pancreatic Adenocarcinoma and Steatohepatitic Hepatocellular Carcinoma in a Patient With a Rare POLE Mutation

Diagnostic Cytopathology, EarlyView.
ABSTRACT Mutations in the DNA polymerase epsilon (POLE) gene are associated with an increased risk of various malignancies, including colorectal and other gastrointestinal, endometrial, ovarian, breast, and brain cancers. In extremely rare cases, POLE mutations have also been associated with pancreatic and hepatobiliary carcinomas.
Lynn Messersmith, Areeba H. Rizvi, Dina El‐Rayes, Jimmie Stewart III   +3 more
wiley   +1 more source

Hepatic Glycogenosis: A Rare Complication of Type 1 Diabetes Mellitus. [PDF]

Cureus
Jemai C, Fakhfakh Y, Hadj Ali Z, Htira Y, Ben Mami F.   +4 more
europepmc   +1 more source

The difficult discussion on the deactivation of implantable cardioverter devices at the end of life: a systematic review

ESC Heart Failure, Volume 12, Issue 2, Page 733-760, April 2025.
Abstract Implantable cardioverter defibrillators (ICDs) reliably prevent death due to life‐threatening arrhythmias; this may become less relevant in people with more severe heart failure who are reaching the end of life (EOL). This review aimed to explore the ICD deactivation process and identify ethical issues, especially around the initiation of ...
Siobhan C. Murray, Claire McNamara, Anna V. Chatzi   +2 more
wiley   +1 more source

Forecasting heart failure: Seasonal alignment of heart failure outcomes in New York

ESC Heart Failure, Volume 12, Issue 2, Page 819-831, April 2025.
Abstract Background Seasonal variations have been observed in heart failure (HF) hospitalization. Numerous explanatory mechanisms have been proposed, but no prior studies have examined potential contributors directly. Our objective was to identify specific factors that could contribute to seasonal variability using a large longitudinal dataset of HF ...
Prerna Gupta, Ellen Brinza, Prateeti Khazanie, Pamela N. Peterson, P Michael Ho, David P. Kao   +5 more
wiley   +1 more source