FimH and Type 1 Pili Mediated Tumor Cell Cytotoxicity by Uropathogenic Escherichia coli In Vitro [PDF]
Pathogens, 2023 Uropathogenic Escherichia coli express hairlike proteinaceous surface projections, known as chaperone–usher pathway (CUP) pili. Type 1 pili are CUP pili with well-established pathogenic properties. The FimH adhesin subunit of type 1 pili plays a key role
Shelly Roselyn Van Eyssen +4 more
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Human Urine Decreases Function and Expression of Type 1 Pili in Uropathogenic
mBio, 2015 Uropathogenic Escherichia coli (UPEC) is the primary cause of community-acquired urinary tract infections (UTIs). UPEC bind the bladder using type 1 pili, encoded by the fim operon in nearly all E. coli.
Sarah E. Greene +4 more
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Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions. [PDF]
PLoS Neglected Tropical Diseases, 2017 Enterotoxigenic Escherichia coli (ETEC), defined by their elaboration of heat-labile (LT) and/or heat-stable (ST) enterotoxins, are a common cause of diarrheal illness in developing countries.
Alaullah Sheikh +7 more
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The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili [PDF]
Nature CommunicationsType 1 pili are important virulence factors of uropathogenic Escherichia coli that mediate bacterial attachment to epithelial cells in the urinary tract.
Dawid S. Zyla +8 more
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Loss of Type 1 Pili and Flagella in Uropathogenic Escherichia coli Leads to Reduced Phagocytosis by Human and Murine Monocytes [PDF]
PathogensBackground: Uropathogenic Escherichia coli (UPEC) is the number one cause of urinary tract infections (UTIs) in humans. The ability to bind to uroepithelial cells through type 1 pili and ascend the urinary tract via flagella is important in the early ...
William R. Schwan
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Rhomboid protease GlpG regulates type 1 pili quality control and virulence in pathogenic E. coli [PDF]
Nature CommunicationsWith the rise in antimicrobial resistance, understanding the virulence factors utilized by pathogenic E. coli is essential for the development of alternative therapeutics. While previous work has shown that disruption of the E.
Jimmy Lu +14 more
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Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 pili. [PDF]
PLoS Pathogens, 2015 Bacterial biofilms account for a significant number of hospital-acquired infections and complicate treatment options, because bacteria within biofilms are generally more tolerant to antibiotic treatment.
Kyle A Floyd +9 more
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Structural basis for adhesin secretion by the outer-membrane usher in type 1 pili. [PDF]
Proc Natl Acad Sci U S AGram-negative bacteria produce chaperone–usher pathway pili, which are extracellular protein fibers tipped with an adhesive protein that binds to a receptor with stereochemical specificity to determine host and tissue tropism. The outer-membrane usher protein, together with a periplasmic chaperone, assembles thousands of pilin ...
Bitter RM +6 more
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Differential contributions of ClpX and ClpP to pulmonary virulence in classical and hypervirulent Klebsiella pneumoniae [PDF]
Infection and ImmunityKlebsiella pneumoniae is an opportunistic Gram-negative pathogen and a common cause of antibiotic-resistant infections including neonatal sepsis and hospital-acquired pneumonia. K.
Nathan M. Lin +3 more
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Pilus of Streptococcus pneumoniae: structure, function and vaccine potential
Frontiers in Cellular and Infection Microbiology, 2023 The pilus is an extracellular structural part that can be detected in some Streptococcus pneumoniae (S. pneumoniae) isolates (type I pili are found in approximately 30% of strains, while type II pili are found in approximately 20%). It is anchored to the
Chenglin Miao +6 more
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