Results 31 to 40 of about 24,830 (176)

Pilicide ec240 Disrupts Virulence Circuits in Uropathogenic Escherichia coli

mBio, 2014
Chaperone-usher pathway (CUP) pili are extracellular organelles produced by Gram-negative bacteria that mediate bacterial pathogenesis. Small-molecule inhibitors of CUP pili, termed pilicides, were rationally designed and shown to inhibit type 1 or P ...
Sarah E. Greene, Jerome S. Pinkner, Erik Chorell, Karen W. Dodson, Carrie L. Shaffer, Matt S. Conover, Jonathan Livny, Maria Hadjifrangiskou, Fredrik Almqvist, Scott J. Hultgren   +9 more
doaj   +1 more source

Reversible adhesion by type IV pili leads to formation of permanent localized clusters

iScience, 2022
Summary: The formation of long-lived, multicellular clusters is a fundamental step in the physiopathology of many disease-causing bacteria. Experiments on abiotic surfaces suggest that bacterial colonization, including initial cluster formation, requires
María Victoria Pepe, Celeste Dea, Camila Genskowsky, Darío Capasso, Mara Sabrina Roset, Adriana Valeria Jäger, Fernando Peruani, Arlinet Kierbel   +7 more
doaj   +1 more source

Speed switching of gonococcal surface motility correlates with proton motive force. [PDF]

PLoS ONE, 2013
Bacterial type IV pili are essential for adhesion to surfaces, motility, microcolony formation, and horizontal gene transfer in many bacterial species. These polymers are strong molecular motors that can retract at two different speeds.
Rainer Kurre, Nadzeya Kouzel, Kanimozhi Ramakrishnan, Enno R Oldewurtel, Berenike Maier   +4 more
doaj   +1 more source

The pilin protein FimP from Actinomyces oris: crystal structure and sequence analyses. [PDF]

PLoS ONE, 2012
The Actinomyces oris type-1 pili are important for the initial formation of dental plaque by binding to salivary proteins that adhere to the tooth surface. Here we present the X-ray structure of FimP, the protein that is polymerized into the type-1 pilus
Karina Persson, Anders Esberg, Rolf Claesson, Nicklas Strömberg   +3 more
doaj   +1 more source

Specific involvement of pilus type 2a in biofilm formation in group B Streptococcus. [PDF]

PLoS ONE, 2010
Streptococcus agalactiae is the primary colonizer of the anogenital mucosa of up to 30% of healthy women and can infect newborns during delivery and cause severe sepsis and meningitis. Persistent colonization usually involves the formation of biofilm and
Cira Daniela Rinaudo, Roberto Rosini, Cesira L Galeotti, Francesco Berti, Francesca Necchi, Valerio Reguzzi, Claudia Ghezzo, John Laird Telford, Guido Grandi, Domenico Maione   +9 more
doaj   +1 more source

Comprehensive Identification of Fim-Mediated Inversions in Uropathogenic Escherichia coli with Structural Variation Detection Using Relative Entropy

mSphere, 2019
Most urinary tract infections (UTIs) are caused by uropathogenic Escherichia coli (UPEC), which depends on an extracellular organelle (type 1 pili) for adherence to bladder cells during infection.
Colin W. Russell, Rashmi Sukumaran, Lu Ting Liow, Balamurugan Periaswamy, Shazmina Rafee, Yuemin C. Chee, Swaine L. Chen   +6 more
doaj   +1 more source

Escherichia coli Biofilm Formation, Motion and Protein Patterns on Hyaluronic Acid and Polydimethylsiloxane Depend on Surface Stiffness

Journal of Functional Biomaterials, 2022
The surface stiffness of the microenvironment is a mechanical signal regulating biofilm growth without the risks associated with the use of bioactive agents.
Annabelle Vigué, Dominique Vautier, Amad Kaytoue, Bernard Senger, Youri Arntz, Vincent Ball, Amine Ben Mlouka, Varvara Gribova, Samar Hajjar-Garreau, Julie Hardouin, Thierry Jouenne, Philippe Lavalle, Lydie Ploux   +12 more
doaj   +1 more source

Safety and immunogenicity of an adjuvanted Escherichia coli adhesin vaccine in healthy women with and without histories of recurrent urinary tract infections: results from a first-in-human phase 1 study

Human Vaccines & Immunotherapeutics, 2021
Antibiotic resistance among gram-negative bacteria continues to rise globally at an alarming rate. New vaccines that prevent bacterial infections and reduce antibiotic use could provide a potential solution to these problems.
Gary R. Eldridge, Heidi Hughey, Lois Rosenberger, Steven M. Martin, Andrew Marc Shapiro, Elizabeth D’Antonio, Kent G. Krejci, Neal Shore, James Peterson, Andrea S. Lukes, Courtney M. Starks   +10 more
doaj   +1 more source

Mucosal fluid glycoprotein DMBT1 suppresses twitching motility and virulence of the opportunistic pathogen Pseudomonas aeruginosa. [PDF]

PLoS Pathogens, 2017
It is generally thought that mucosal fluids protect underlying epithelial surfaces against opportunistic infection via their antimicrobial activity.
Jianfang Li, Matteo M E Metruccio, David J Evans, Suzanne M J Fleiszig   +3 more
doaj   +1 more source

Proteolytic activity of meprins α and β on AIEC LF82 type 1 pili.

, 2013
A, proteolytic effect of various concentrations (from 1 µg/ml to 100 µg/ml) of meprins on purified AIEC LF82 type 1 pili. Proteins were loaded on 15% polyacrylamid gel for SDS-PAGE and stained with Coomassie brilliant blue.
Christophe Chambon (349600), Christoph Becker-Pauly (197133), Emilie Vazeille (349596), Arlette Darfeuille-Michaud (112082), Sylvia L. F. Pender (349604), Daniel Lottaz (46126), Christine Jakob (349608), Stefan Müller (89), Aurélie Gardarin (349598), Marie-Agnès Bringer (349597)   +9 more
core   +1 more source