Results 31 to 40 of about 24,886 (187)

The pilin protein FimP from Actinomyces oris: crystal structure and sequence analyses. [PDF]

PLoS ONE, 2012
The Actinomyces oris type-1 pili are important for the initial formation of dental plaque by binding to salivary proteins that adhere to the tooth surface. Here we present the X-ray structure of FimP, the protein that is polymerized into the type-1 pilus
Karina Persson, Anders Esberg, Rolf Claesson, Nicklas Strömberg   +3 more
doaj   +1 more source

Specific involvement of pilus type 2a in biofilm formation in group B Streptococcus. [PDF]

PLoS ONE, 2010
Streptococcus agalactiae is the primary colonizer of the anogenital mucosa of up to 30% of healthy women and can infect newborns during delivery and cause severe sepsis and meningitis. Persistent colonization usually involves the formation of biofilm and
Cira Daniela Rinaudo, Roberto Rosini, Cesira L Galeotti, Francesco Berti, Francesca Necchi, Valerio Reguzzi, Claudia Ghezzo, John Laird Telford, Guido Grandi, Domenico Maione   +9 more
doaj   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Comprehensive Identification of Fim-Mediated Inversions in Uropathogenic Escherichia coli with Structural Variation Detection Using Relative Entropy

mSphere, 2019
Most urinary tract infections (UTIs) are caused by uropathogenic Escherichia coli (UPEC), which depends on an extracellular organelle (type 1 pili) for adherence to bladder cells during infection.
Colin W. Russell, Rashmi Sukumaran, Lu Ting Liow, Balamurugan Periaswamy, Shazmina Rafee, Yuemin C. Chee, Swaine L. Chen   +6 more
doaj   +1 more source

Escherichia coli Biofilm Formation, Motion and Protein Patterns on Hyaluronic Acid and Polydimethylsiloxane Depend on Surface Stiffness

Journal of Functional Biomaterials, 2022
The surface stiffness of the microenvironment is a mechanical signal regulating biofilm growth without the risks associated with the use of bioactive agents.
Annabelle Vigué, Dominique Vautier, Amad Kaytoue, Bernard Senger, Youri Arntz, Vincent Ball, Amine Ben Mlouka, Varvara Gribova, Samar Hajjar-Garreau, Julie Hardouin, Thierry Jouenne, Philippe Lavalle, Lydie Ploux   +12 more
doaj   +1 more source

Safety and immunogenicity of an adjuvanted Escherichia coli adhesin vaccine in healthy women with and without histories of recurrent urinary tract infections: results from a first-in-human phase 1 study

Human Vaccines & Immunotherapeutics, 2021
Antibiotic resistance among gram-negative bacteria continues to rise globally at an alarming rate. New vaccines that prevent bacterial infections and reduce antibiotic use could provide a potential solution to these problems.
Gary R. Eldridge, Heidi Hughey, Lois Rosenberger, Steven M. Martin, Andrew Marc Shapiro, Elizabeth D’Antonio, Kent G. Krejci, Neal Shore, James Peterson, Andrea S. Lukes, Courtney M. Starks   +10 more
doaj   +1 more source

Mucosal fluid glycoprotein DMBT1 suppresses twitching motility and virulence of the opportunistic pathogen Pseudomonas aeruginosa. [PDF]

PLoS Pathogens, 2017
It is generally thought that mucosal fluids protect underlying epithelial surfaces against opportunistic infection via their antimicrobial activity.
Jianfang Li, Matteo M E Metruccio, David J Evans, Suzanne M J Fleiszig   +3 more
doaj   +1 more source

Regulation of Type 1 Pili Expression as Exemplified by Escherichia Coli Strain M17

Bulletin of Experimental Biology and Medicine, 2001
Studies of E. coli strain M17 colibacterin and its derivatives showed that fimH gene regulates morphological characteristics of type 1 fimbria and cell piliation on the whole. Gene fimH has a negative effect and decreased the percentage of piliated cells in the population and piliation of individual cells, which does not agree with its role of a ...
Chesnokova V.L., Rieger P., Sokurenko E.V.   +2 more
openaire   +4 more sources

FimH adhesin of type 1 pili is assembled into a fibrillar tip structure in the Enterobacteriaceae. [PDF]

Proceedings of the National Academy of Sciences, 1995
Type 1 pili are heteropolymeric mannosebinding fibers produced by all members of the Enterobacteriaceae family. The bulk of the fiber is composed of FimA. Two macromolecular complexes responsible for mediating an interaction with mannose-containing receptors were purified from fimA- Escherichia coli by mannose affinity chromatography and ion-exchange ...
C H, Jones, J S, Pinkner, R, Roth, J, Heuser, A V, Nicholes, S N, Abraham, S J, Hultgren   +6 more
openaire   +2 more sources

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source