Assembly Mechanism of FCT Region Type 1 Pili in Serotype M6 Streptococcus pyogenes [PDF]
Journal of Biological Chemistry, 2011 The human pathogen Streptococcus pyogenes produces diverse pili depending on the serotype. We investigated the assembly mechanism of FCT type 1 pili in a serotype M6 strain. The pili were found to be assembled from two precursor proteins, the backbone protein T6 and ancillary protein FctX, and anchored to the cell wall in a manner that requires both a ...
Masanobu, Nakata +13 more
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Pilicide ec240 Disrupts Virulence Circuits in Uropathogenic
mBio, 2014 Chaperone-usher pathway (CUP) pili are extracellular organelles produced by Gram-negative bacteria that mediate bacterial pathogenesis. Small-molecule inhibitors of CUP pili, termed pilicides, were rationally designed and shown to inhibit type 1 or P ...
Sarah E. Greene +9 more
doaj +1 more source
Reversible adhesion by type IV pili leads to formation of permanent localized clusters
iScience, 2022 Summary: The formation of long-lived, multicellular clusters is a fundamental step in the physiopathology of many disease-causing bacteria. Experiments on abiotic surfaces suggest that bacterial colonization, including initial cluster formation, requires
María Victoria Pepe +7 more
doaj +1 more source
Alternative mechanism for bacteriophage adsorption to the motile bacterium Caulobacter crescentus [PDF]
, 2011 2D and 3D cryo-electron microscopy, together with adsorption kinetics assays of ϕCb13 and ϕCbK phage-infected Caulobacter crescentus, provides insight into the mechanisms of infection.
Ackermann +45 more
core +4 more sources
Regulation of production of type 1 pili among urinary tract isolates of Escherichia coli [PDF]
Infection and Immunity, 1986 The piliation and hemagglutination properties of 54 consecutive Escherichia coli isolates from women with recurrent urinary tract infections were studied. Mannose-sensitive hemagglutination (MSHA) of guinea pig erythrocytes, characteristic of type 1-piliated bacteria, was produced by 75% of the isolates, 32% produced mannose-insensitive ...
S J, Hultgren +3 more
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The structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket [PDF]
, 2012 P pili are hairlike polymeric structures that mediate binding of uropathogenic Escherichia coli to the surface of the kidney via the PapG adhesin at their tips.
Baga M +48 more
core +2 more sources
The pilin protein FimP from Actinomyces oris: crystal structure and sequence analyses. [PDF]
PLoS ONE, 2012 The Actinomyces oris type-1 pili are important for the initial formation of dental plaque by binding to salivary proteins that adhere to the tooth surface. Here we present the X-ray structure of FimP, the protein that is polymerized into the type-1 pilus
Karina Persson +3 more
doaj +1 more source
Expression of Cellulosome Components and Type IV Pili within the Extracellular Proteome of Ruminococcus flavefaciens 007 [PDF]
, 2013 Funding: The Rowett Institute receives funding from SG-RESAS (Scottish Government Rural and Environmental Science and Analysis Service). Visit of M.V.
Bayer, Edward A. +12 more
core +3 more sources
Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli.
PLoS Pathogens, 2007 Uropathogenic Escherichia coli (UPEC), the primary causative agent of urinary tract infections, typically express filamentous adhesive organelles called type 1 pili that mediate both bacterial attachment to and invasion of bladder urothelial cells ...
Danelle S Eto +3 more
doaj +1 more source
Speed switching of gonococcal surface motility correlates with proton motive force. [PDF]
PLoS ONE, 2013 Bacterial type IV pili are essential for adhesion to surfaces, motility, microcolony formation, and horizontal gene transfer in many bacterial species. These polymers are strong molecular motors that can retract at two different speeds.
Rainer Kurre +4 more
doaj +1 more source