Structural basis for adhesin secretion by the outer-membrane usher in type 1 pili. [PDF]
Proc Natl Acad Sci U S AGram-negative bacteria produce chaperone-usher pathway pili, which are extracellular protein fibers tipped with an adhesive protein that binds to a receptor with stereochemical specificity to determine host and tissue tropism.
Bitter RM +6 more
europepmc +2 more sources
Microbiology Spectrum, 2021 Streptococcus sanguinis is a common cause of infective endocarditis (IE). Efforts by research groups are aimed at identifying and characterizing virulence factors that contribute to the ability of this organism to cause IE.
Anthony M. Martini +3 more
doaj +1 more source
A Small Non-Coding RNA Modulates Expression of Pilus-1 Type in Streptococcus pneumoniae
Microorganisms, 2021 Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide, and about 30% of the pneumococcal clinical isolates show type I pili-like structures.
Paloma Acebo +6 more
doaj +1 more source
A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis.
PLoS Pathogens, 2021 Type 1 pili have long been considered the major virulence factor enabling colonization of the urinary bladder by uropathogenic Escherichia coli (UPEC). The molecular pathogenesis of pyelonephritis is less well characterized, due to previous limitations ...
Lisa K McLellan +12 more
doaj +1 more source
Crystal structure of the P pilus rod subunit PapA [PDF]
, 2007 P pili are important adhesive fibres involved in kidney infection by uropathogenic Escherichia coli strains. P pili are assembled by the conserved chaperone-usher pathway, which involves the PapD chaperone and the PapC usher.
Bullitt, E +12 more
core +1 more source
Human Neutrophil’S Chemotaxis and Intracellular Killing in Response to Type 1 Piliated Uropathogenic Escherichia Coli [PDF]
Iranian Journal of Public Health, 2007 Introduction: Uropathogenic Escherichia coli (UPEC), the commonest cause of urinary tract infections, bind to target cells and phagocytes via several distinct pairs of adhesins and receptors.
N Nooritalab, SH Najar Peerayeh
doaj +2 more sources
In silico analysis of usher encoding genes in Klebsiella pneumoniae and characterization of their role in adhesion and colonization. [PDF]
PLoS ONE, 2015 Chaperone/usher (CU) assembly pathway is used by a wide range of Enterobacteriaceae to assemble adhesive surface structures called pili or fimbriae that play a role in bacteria-host cell interactions.
Fida Khater +5 more
doaj +1 more source
Stochastic chain termination in bacterial pilus assembly
Nature Communications, 2023 Adhesive type 1 pili from uropathogenic Escherichia coli strains are filamentous, supramolecular protein complexes consisting of a short tip fibrillum and a long, helical rod formed by up to several thousand copies of the major pilus subunit FimA.
Christoph Giese +7 more
doaj +1 more source
Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions
eLife, 2018 Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut.
Caitlin N Spaulding +12 more
doaj +1 more source
FrzS regulates social motility in Myxococcus xanthus by controlling exopolysaccharide production. [PDF]
PLoS ONE, 2011 Myxococcus xanthus Social (S) motility occurs at high cell densities and is powered by the extension and retraction of Type IV pili which bind ligands normally found in matrix exopolysaccharides (EPS).
James E Berleman +5 more
doaj +1 more source