In silico analysis of usher encoding genes in Klebsiella pneumoniae and characterization of their role in adhesion and colonization. [PDF]
PLoS ONE, 2015 Chaperone/usher (CU) assembly pathway is used by a wide range of Enterobacteriaceae to assemble adhesive surface structures called pili or fimbriae that play a role in bacteria-host cell interactions.
Fida Khater +5 more
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Microorganisms, 2021 Pathogens are exposed to a multitude of harmful conditions imposed by the environment of the host. Bacterial responses against these stresses are pivotal for successful host colonization and pathogenesis. In the case of many E.
Hicham Bessaiah +3 more
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Stochastic chain termination in bacterial pilus assembly
Nature Communications, 2023 Adhesive type 1 pili from uropathogenic Escherichia coli strains are filamentous, supramolecular protein complexes consisting of a short tip fibrillum and a long, helical rod formed by up to several thousand copies of the major pilus subunit FimA.
Christoph Giese +7 more
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Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions
eLife, 2018 Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut.
Caitlin N Spaulding +12 more
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FrzS regulates social motility in Myxococcus xanthus by controlling exopolysaccharide production. [PDF]
PLoS ONE, 2011 Myxococcus xanthus Social (S) motility occurs at high cell densities and is powered by the extension and retraction of Type IV pili which bind ligands normally found in matrix exopolysaccharides (EPS).
James E Berleman +5 more
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Pilicide ec240 Disrupts Virulence Circuits in Uropathogenic
mBio, 2014 Chaperone-usher pathway (CUP) pili are extracellular organelles produced by Gram-negative bacteria that mediate bacterial pathogenesis. Small-molecule inhibitors of CUP pili, termed pilicides, were rationally designed and shown to inhibit type 1 or P ...
Sarah E. Greene +9 more
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Reversible adhesion by type IV pili leads to formation of permanent localized clusters
iScience, 2022 Summary: The formation of long-lived, multicellular clusters is a fundamental step in the physiopathology of many disease-causing bacteria. Experiments on abiotic surfaces suggest that bacterial colonization, including initial cluster formation, requires
María Victoria Pepe +7 more
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Assembly Mechanism of FCT Region Type 1 Pili in Serotype M6 Streptococcus pyogenes [PDF]
Journal of Biological Chemistry, 2011 The human pathogen Streptococcus pyogenes produces diverse pili depending on the serotype. We investigated the assembly mechanism of FCT type 1 pili in a serotype M6 strain. The pili were found to be assembled from two precursor proteins, the backbone protein T6 and ancillary protein FctX, and anchored to the cell wall in a manner that requires both a ...
Masanobu, Nakata +13 more
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Speed switching of gonococcal surface motility correlates with proton motive force. [PDF]
PLoS ONE, 2013 Bacterial type IV pili are essential for adhesion to surfaces, motility, microcolony formation, and horizontal gene transfer in many bacterial species. These polymers are strong molecular motors that can retract at two different speeds.
Rainer Kurre +4 more
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Regulation of production of type 1 pili among urinary tract isolates of Escherichia coli [PDF]
Infection and Immunity, 1986 The piliation and hemagglutination properties of 54 consecutive Escherichia coli isolates from women with recurrent urinary tract infections were studied. Mannose-sensitive hemagglutination (MSHA) of guinea pig erythrocytes, characteristic of type 1-piliated bacteria, was produced by 75% of the isolates, 32% produced mannose-insensitive ...
S J, Hultgren +3 more
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