Loss of Type 1 Pili and Flagella in Uropathogenic Escherichia coli Leads to Reduced Phagocytosis by Human and Murine Monocytes [PDF]
PathogensBackground: Uropathogenic Escherichia coli (UPEC) is the number one cause of urinary tract infections (UTIs) in humans. The ability to bind to uroepithelial cells through type 1 pili and ascend the urinary tract via flagella is important in the early ...
William R. Schwan
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Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 pili. [PDF]
PLoS Pathogens, 2015 Bacterial biofilms account for a significant number of hospital-acquired infections and complicate treatment options, because bacteria within biofilms are generally more tolerant to antibiotic treatment.
Kyle A Floyd +9 more
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Rhomboid protease GlpG regulates type 1 pili quality control and virulence in pathogenic E. coli [PDF]
Nature CommunicationsWith the rise in antimicrobial resistance, understanding the virulence factors utilized by pathogenic E. coli is essential for the development of alternative therapeutics. While previous work has shown that disruption of the E.
Jimmy Lu +14 more
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The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili [PDF]
Nature CommunicationsType 1 pili are important virulence factors of uropathogenic Escherichia coli that mediate bacterial attachment to epithelial cells in the urinary tract.
Dawid S. Zyla +8 more
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PlantsType IVc Pili (T4cP), also known as Tad or Flp pili, are long thin microbial filaments that are made up of small-sized pilins. These appendages serve different functions in bacteria, including attachment, biofilm formation, surface sensing, motility, and
Cristina Carvia-Hermoso +4 more
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Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli.
PLoS Pathogens, 2007 Uropathogenic Escherichia coli (UPEC), the primary causative agent of urinary tract infections, typically express filamentous adhesive organelles called type 1 pili that mediate both bacterial attachment to and invasion of bladder urothelial cells ...
Danelle S Eto +3 more
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What Flips the Switch? Signals and Stress Regulating Extraintestinal Pathogenic Escherichia coli Type 1 Fimbriae (Pili) [PDF]
Microorganisms, 2021 Pathogens are exposed to a multitude of harmful conditions imposed by the environment of the host. Bacterial responses against these stresses are pivotal for successful host colonization and pathogenesis. In the case of many E.
Hicham Bessaiah +3 more
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Differential contributions of ClpX and ClpP to pulmonary virulence in classical and hypervirulent Klebsiella pneumoniae [PDF]
Infection and ImmunityKlebsiella pneumoniae is an opportunistic Gram-negative pathogen and a common cause of antibiotic-resistant infections including neonatal sepsis and hospital-acquired pneumonia. K.
Nathan M. Lin +3 more
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Characterization of H/D exchange in type 1 pili by proton-detected solid-state NMR and molecular dynamics simulations. [PDF]
J Biomol NMR, 2019 Uropathogenic Escherichia coli invades and colonizes hosts by attaching to cells using adhesive pili on the bacterial surface. Although many biophysical techniques have been used to study the structure and mechanical properties of pili, many important ...
Hwang S +6 more
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Pilus of Streptococcus pneumoniae: structure, function and vaccine potential
Frontiers in Cellular and Infection Microbiology, 2023 The pilus is an extracellular structural part that can be detected in some Streptococcus pneumoniae (S. pneumoniae) isolates (type I pili are found in approximately 30% of strains, while type II pili are found in approximately 20%). It is anchored to the
Chenglin Miao +6 more
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