Results 31 to 40 of about 5,917,232 (403)
Association of a Low-Frequency Variant in HNF1A With Type 2 Diabetes in a Latino Population [PDF]
, 2014 Importance: Latino populations have one of the highest prevalences of type 2 diabetes worldwide. Objectives: To investigate the association between rare protein-coding genetic variants and prevalence of type 2 diabetes in a large Latino population and to Aukrust, Ingvild, Bjørkhaug, Lise, Estrada, Karol, MacArthur, Daniel G., Najmi, Laeya Abdoli, Njølstad, Pål Rasmus, The SIGMA Type 2 Diabetes Consortium +6 morecore +1 more sourceCanagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.
New England Journal of Medicine, 2019 BACKGROUND
Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium-glucose cotransporter 2 (SGLT2), exploratory results have ...V. Perkovic, M. Jardine, B. Neal, Severine Bompoint, H. Heerspink, D. Charytan, Robert Edwards, R. Agarwal, G. Bakris, S. Bull, C. Cannon, G. Capuano, P. Chu, D. de Zeeuw, T. Greene, A. Levin, C. Pollock, D. Wheeler, Yshai Yavin, Hong Zhang, B. Zinman, G. Meininger, B. Brenner, K. Mahaffey +23 moresemanticscholar +1 more sourcePhenotypic continuum of NFU1‐related disorders
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2025-2035, December 2022., 2022 Abstract
Bi‐allelic variants in Iron–Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early‐onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra‐rare bi‐allelic NFU1 missense variants associated with a Rauan Kaiyrzhanov, Maha S. Zaki, Tracy Lau, Sambuddha Sen, Reza Azizimalamiri, Mina Zamani, Gözde Yeşil Sayin, Taru Hilander, Stephanie Efthymiou, Viorica Chelban, Ruth Brown, Kyle Thompson, Maria Irene Scarano, Jaya Ganesh, Kairgali Koneev, Ismail Musab Gülaçar, Richard Person, Dinara Sadykova, Yerdan Maidyrov, Tahereh Seifi, Aizhan Zadagali, Geneviève Bernard, Katrina Allis, Houda Zghal Elloumi, Amanda Lindy, Ehsan Taghiabadi, Sumit Verma, Rachel Logan, Brian Kirmse, Renkui Bai, Shaimaa M. Khalaf, Mohamed S. Abdel‐Hamid, Alireza Sedaghat, Gholamreza Shariati, Mahmoud Issa, Jawaher Zeighami, Hasnaa M. Elbendary, Garry Brown, Robert W. Taylor, Hamid Galehdari, Joseph J. Gleeson, Christopher J. Carroll, James A. Cowan, Andres Moreno‐De‐Luca, Henry Houlden, Reza Maroofian +45 morewiley +1 more sourceCanagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
New England Journal of Medicine, 2017 Background Canagliflozin is a sodium–glucose cotransporter 2 inhibitor that reduces glycemia as well as blood pressure, body weight, and albuminuria in people with diabetes.B. Neal, V. Perkovic, K. Mahaffey, D. de Zeeuw, G. Fulcher, N. Erondu, Wayne Shaw, G. Law, Mehul Desai, D. Matthews +9 moresemanticscholar +1 more sourceThe genetic architecture of type 2 diabetes [PDF]
Nature, 2016 The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability.Vincent K. L. Lam, Torben Jørgensen, Torben Jørgensen, Danish Saleheen, Dorothée Thuillier, Christian Fuchsberger, Christian Fuchsberger, Oluf Pedersen, James B. Meigs, Tien Yin Wong, Tien Yin Wong, Manjinder S. Sandhu, Manjinder S. Sandhu, Peter M. Nilsson, Yongkang Kim, Eric S. Lander, Christopher J. Groves, Dwaipayan Bharadwaj, Weiping Jia, Philippe Froguel, Philippe Froguel, Davis J. McCarthy, Sobha Puppala, Jennifer E. Below, Nikhil Tandon, Inês Barroso, Inês Barroso, Kyong Soo Park, João Fadista, Christian Gieger, Denis Rybin, Cheng Hu, Ryan P. Welch, Gonçalo R. Abecasis, Andrew D. Morris, Andrew D. Morris, Reedik Mägi, Hyun Min Kang, Graeme I. Bell, Yoon Shin Cho, Thomas Illig, Leena Kinnunen, Rainer Rauramaa, Xueling Sim, Iksoo Huh, Heather M. Stringham, Pamela J. Hicks, Juyoung Lee, Jason Flannick, Jason Flannick, Allan Linneberg, Christopher Hartl, Shah Ebrahim, Fredrik Karpe, Tiinamaija Tuomi, Wing-Yee So, Lili Milani, Toni I. Pollin, Ryan Poplin, James G. Wilson, Tanya M. Teslovich, Joanne E. Curran, Nicholas J. Wareham, Johanna Kuusisto, Daniel E. Hale, Marie Loh, Marie Loh, Marie Loh, Kee Seng Chia, Narisu Narisu, Cecilia M. Lindgren, Cecilia M. Lindgren, Valeriya Lyssenko, Andrew Farmer, Claudia Langenberg, Thomas W. Blackwell, Phoenix Kwan, Torben Hansen, Torben Hansen, Pablo Cingolani, John R. B. Perry, Jonathan C. Levy, Robert C. Onofrio, Rector Arya, Xu Wang, Yingchang Lu, Jennifer Kriebel, Jette Bork-Jensen, Dorairaj Prabhakaran, Michael L. Stitzel, Karen L. Mohlke, Yik Ying Teo, Mark Seielstad, Mark Seielstad, Olov Rolandsson, Teemu Kuulasmaa, Neil Robertson, Annette Peters, Thomas Schwarzmayr, Jong-Young Lee, Erwin P. Bottinger, Stephen O'Rahilly, Lu Qi, Panos Deloukas, Panos Deloukas, Marju Orho-Melander, David Aguilar, Michael Boehnke, Lars Lind, Taylor J. Maxwell, Peter S. Chines, Dorota Pasko, Lori L. Bonnycastle, Benjamin Lehne, Dylan Hodgkiss, Claes Ladenvall, George B. Grant, Jae-Hoon Lee, Vineeta Agarwala, Vineeta Agarwala, Jianjun Liu, Jianjun Liu, Martina Müller-Nurasyid, Robert A. Scott, John Blangero, Vilmantas Giedraitis, Pierre Fontanillas, Nir Barzilai, Han Chen, Han Chen, Loukas Moutsianas, Tin Aung, Tin Aung, Lars Lannfelt, Adam S. Butterworth, Leif Groop, Leif Groop, Ravindranath Duggirala, Craig L. Hanis, Olle Melander, Donna M. Lehman, Evelin Mihailov, Liisa Hakaste, Konstantin Strauch, Jasmina Kravic, Qibin Qi, Qibin Qi, Kyle J. Gaulton, Alisa K. Manning, Heiner Boeing, Christian Herder, Vidya S. Farook, Clement Ma, Bong-Jo Kim, Massimo Mangino, Alena Stančáková, Tasha E. Fingerlin, Nancy J. Cox, Juliana C.N. Chan, Harald Grallert, Paul Elliott, Timothy Fennell, Erik Ingelsson, Erik Ingelsson, Matt Neville, Ann-Christine Syvänen, Amy J. Swift, N. William Rayner, N. William Rayner, Laura J. Scott, Eric R. Gamazon, Adam E. Locke, Beverley Balkau, Wei Zhao, Joanna M. M. Howson, Jose C. Florez, Jose C. Florez, Kathleen Stirrups, William R. Scott, Marit E. Jørgensen, Young-Jin Kim, Thomas Wieland, Gregory P. Wilson, Shaun Purcell, Shaun Purcell, Shaun Purcell, Anna L. Gloyn, Farook Thameem, Yoshihiko Nagai, Timothy M. Frayling, Noël P. Burtt, Jeroen R. Huyghe, Keng-Han Lin, Satish Kumar, Martijn van de Bunt, Anders Rosengren, Mette Hollensted, Mark I. McCarthy, Francis S. Collins, Pål R. Njølstad, Anette P. Gjesing, Colin N. A. Palmer, Nicholette D. Palmer, Anubha Mahajan, Annemari Käräjämäki, Heikki A. Koistinen, Yvonne T. van der Schouw, Michael Roden, Peter Donnelly, Niels Grarup, Carmen Navarro, Mohammad Kamran Ikram, Gemma Buck, Loic Yengo, Tibor V. Varga, Andrew R. Wood, Thomas Meitinger, Giriraj R. Chandak, Paul W. Franks, Cornelia Huth, Richard D. Pearson, Andrew T. Hattersley, Sharon P. Fowler, Benjamin Glaser, Gil Atzmon, Ruth J. F. Loos, Chiea Chuen Khor, Ronald C.W. Ma, John Danesh, Richard N. Bergman, E. Shyong Tai, Johanne Marie Justesen, Robert Sladek, Ching-Yu Cheng, Kerrin S. Small, Benjamin F. Voight, Inga Prokopenko, Ivan Brandslund, Jinyan Huang, Christa Meisinger, Goo Jun +240 moreopenaire +15 more sourcesA potential biomarker of cognitive impairment: The olfactory dysfunction and its genes expression
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1884-1897, December 2022., 2022 Abstract Objective
Accumulation evidence has reported that olfactory impairment may be an essential clinical marker and predictor of mild cognitive impairment or Alzheimer's disease. Method
Participants were enrolled in the population‐based, prospective study in Fuxin county, Liaoning province, China between 2019 and 2021.Jiayi Song, Jiahui Xu, Wei Yuan, Ruixue Li, Hui Guo, Hanshu Gao, Cuiying Gu, Wenjing Feng, Yanan Ma, Haiqiang Guo, Zhaoqing Sun, Liqiang Zheng +11 morewiley +1 more sourceLatent Autoimmune Diabetes in Adults in the United Arab Emirates: Clinical Features and Factors Related to Insulin-Requirement [PDF]
, 2015 AIMS:
To describe and to characterize clinical features of latent autoimmune diabetes in adults (LADA) compared to type 1 and type 2 diabetes in the UAE.Al Tikriti, Alia, Barakat, Maha T., Buzzetti, Raffaella, Lessan, Nader, Maddaloni, Ernesto, Pozzilli, Paolo +5 morecore +3 more sourcesPrevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.
New England Journal of Medicine, 2001 BACKGROUND
Type 2 diabetes mellitus is increasingly common, primarily because of increases in the prevalence of a sedentary lifestyle and obesity. Whether type 2 diabetes can be prevented by interventions that affect the lifestyles of subjects at high ...J. Tuomilehto, J. Lindström, J. Eriksson, T. Valle, H. Hämäläinen, P. Ilanne-Parikka, S. Keinänen-Kiukaanniemi, M. Laakso, A. Louheranta, M. Rastas, V. Salminen, S. Aunola, Z. Cepaitis, V. Moltchanov, M. Hakumäki, M. Mannelin, V. Martikkala, J. Sundvall, M. Uusitupa +18 moresemanticscholar +1 more sourceCardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes.
New England Journal of Medicine, 2021 BACKGROUND
Finerenone, a selective nonsteroidal mineralocorticoid receptor antagonist, has favorable effects on cardiorenal outcomes in patients with predominantly stage 3 or 4 chronic kidney disease (CKD) with severely elevated albuminuria and type 2 ...B. Pitt, G. Filippatos, R. Agarwal, S. Anker, G. Bakris, P. Rossing, A. Joseph, P. Kolkhof, C. Nowack, Patrick Schloemer, L. Ruilope +10 moresemanticscholar +1 more source
