Results 41 to 50 of about 5,603,984 (294)

Integration of disease-specific single nucleotide polymorphisms, expression quantitative trait loci and coexpression networks reveal novel candidate genes for type 2 diabetes. [PDF]

, 2012
Aims/hypothesisWhile genome-wide association studies (GWASs) have been successful in identifying novel variants associated with various diseases, it has been much more difficult to determine the biological mechanisms underlying these associations ...
Butte, AJ, Chen, R, Corona, E, Kang, HP, Schadt, EE, Yang, X, Zhang, B   +6 more
core   +2 more sources

Hypoglycaemia in Type 2 diabetes [PDF]

Diabetic Medicine, 2008
AbstractThe primary cause of hypoglycaemia in Type 2 diabetes is diabetes medication—in particular, those which raise insulin levels independently of blood glucose, such as sulphonylureas (SUs) and exogenous insulin. The risk of hypoglycaemia is increased in older patients, those with longer diabetes duration, lesser insulin reserve and perhaps in the ...
Amiel, S A, Dixon, T, Mann, R, Jameson, K   +3 more
openaire   +4 more sources

Pathophysiology of Type 2 Diabetes Mellitus

International Journal of Molecular Sciences, 2020
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to ...
U. Galicia-Garcia, A. Benito-Vicente, S. Jebari, A. Larrea-Sebal, H. Siddiqi, K. Uribe, H. Ostolaza, César Martín   +7 more
semanticscholar   +1 more source

Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach

Diabetes Care, 2012
Glycemic management in type 2 diabetes mellitus has become increasingly complex and, to some extent, controversial, with a widening array of pharmacological agents now available (1–5), mounting concerns about their potential adverse effects and new ...
S. Inzucchi, R. Bergenstal, J. Buse, M. Diamant, E. Ferrannini, M. Nauck, A. Peters, A. Tsapas, R. Wender, D. R. Matthews   +9 more
semanticscholar   +1 more source

Type-2 diabetes

Annals of Internal Medicine
Type 2 diabetes (T2D) is a prevalent disease that increases risk for vascular, renal, and neurologic complications. Prevention and treatment of T2D and its complications are paramount. Many advancements in T2D care have emerged over the past 5 years, including increased understanding of the importance of early intensive glycemic control, mental health,
Skoradal, May-Britt, Andersen, Thomas Rostgaard, Mohr, Magni, Schmidt, Jakob Friis, Bangsbo, Jens   +4 more
openaire   +5 more sources

Recommendations for diabetes type 2

Revista de la Sociedad Argentina de Diabetes, 2016
La diabetes es una enfermedad crónica y compleja que requiere de atención médica continua, con intervenciones que van más allá del mero control de la glucemia.
María Cristina Faingold
doaj   +1 more source

Type 2 diabetes and bone [PDF]

Journal of Bone and Mineral Research, 2012
Abstract There is a growing body of research showing that diabetes is an independent risk factor for fracture. Type 2 diabetes (T2D), which predominates in older individuals and is increasing globally as a consequence of the obesity epidemic, is associated with normal or even increased dual-energy x-ray absorptiometry (DXA)-derived areal
Leslie, William D., Rubin, Mishaela R., Schwartz, Ann V., Kanis, John A.   +3 more
openaire   +4 more sources

Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population [PDF]

, 2008
Background Recent studies have implicated variants of the transcription factor 7-like 2 (TCF7L2) gene in genetic susceptibility to type 2 diabetes mellitus in several different populations. The aim of this study was to determine whether variants of this
A Helgason, Abigail C Britten, AH Barnett, Anthony H Barnett, C Zhang, CM Damcott, GR Chandak, J Paul O'Hare, J Wang, JC Barrett, JC Florez, JC Florez, JV van Vliet-Ostaptchouk, LJ Scott, M Ann Kelly, R Saxena, R Zhang, RJ Loos, S Cauchi, S Cauchi, S Mayans, SE Humphries, SF Grant, Simon D Rees, Srikanth Bellary, Sudhesh Kumar, The International HapMap Consortium, U Smith, WHO Consultation   +28 more
core   +6 more sources

Cohort profile: the ‘Biomarkers of heterogeneity in type 1 diabetes’ study—a national prospective cohort study of clinical and metabolic phenotyping of individuals with long-standing type 1 diabetes in the Netherlands

BMJ Open
Purpose The ‘Biomarkers of heterogeneity in type 1 diabetes’ study cohort was set up to identify genetic, physiological and psychosocial factors explaining the observed heterogeneity in disease progression and the development of complications in people ...
, Erwin Birnie, Giesje Nefs, Bruce H R Wolffenbuttel, Melanie M van der Klauw, Peter R van Dijk, Klaas Hoogenberg, Henk J Veeze, Henk-Jan Aanstoot, Bruce HR Wolffenbuttel, Charlotte E Vollenbrock, Pim Dekker, Lianne S M Boesten, Martine M C de Vries-Velraeds, Adriaan Kooy, Dick Mul, Sanjoy Dutta, Rita D M Varkevisser, Michael P Brugts, Petronella H L M Duijvestijn, Christine Fransman, Rob K Gonera, Esther Latres, Sandra Loves, Theo Sas, Marleen J Vosjan-Noeverman, Rita DM Varkevisser, Lianne SM Boesten, Peter R van Dijk, Petronella HLM Duijvestijn, Martine MC de Vries-Velraeds, Melanie M van der Klauw   +31 more
doaj   +1 more source

Dyslipidemia in type 2 diabetes mellitus [PDF]

Arhiv za farmaciju, 2019
Type 2 diabetes mellitus is a chronic high-prevalence metabolic disease, which is characterized by hyperglycaemia, but also with lipid and protein metabolism disorders.
Stefanović Aleksandra, Zeljković Aleksandra, Vekić Jelena, Spasojević-Kalimanovska Vesna, Jelić-Ivanović Zorana, Spasić Slavica   +5 more
doaj   +1 more source