Results 41 to 50 of about 2,092,825 (312)

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Automatically Explaining Machine Learning Prediction Results: A Demonstration on Type 2 Diabetes Risk Prediction [PDF]

Gang Luo. Automatically Explaining Machine Learning Prediction Results: A Demonstration on Type 2 Diabetes Risk Prediction. Health Information Science and Systems, Vol. 4, No. 2, Mar. 2016, 2018
Background: Predictive modeling is a key component of solutions to many healthcare problems. Among all predictive modeling approaches, machine learning methods often achieve the highest prediction accuracy, but suffer from a long-standing open problem precluding their widespread use in healthcare.
arxiv   +1 more source

Deconstructing Type 2 Diabetes [PDF]

Cell, 1999
There is a natural temptation to extrapolate insights from these animal models to explain the pathophysiology of human diabetes. In some cases, the animal model closely resembles the human disease, as is the case with glucokinase knockout mice and MODY2.
openaire   +3 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Simvastatin Use in Patients with Type 2 Diabetes Mellitus: The Effects on Oxidative Stress

Oman Medical Journal, 2015
Objectives: Studies have shown that people with type 2 diabetes mellitus (T2DM)may develop atherosclerosis due to the disturbance in oxidative control and progressive dyslipidemia.
Mohammad A. Abdelhussein, Ammar R. M. Rudha, Dina A. Jamil, Hayder A. Al-Aubaidy   +3 more
doaj   +1 more source

Approach to: Type 2 diabetes management

McGill Journal of Medicine, 2021
Type 2 Diabetes Mellitus (T2DM) is a chronic and insidious disease that is on the rise worldwide. Diabetes pharmacotherapy is complex and varied, and recent studies of novel antihyperglycemic drugs have raised important considerations for the management ...
Susan Joanne Wang
doaj   +1 more source

Exercise and type 2 diabetes [PDF]

, 2021
Proefschrift dat onder andere een tweejarig interventie-onderzoek beschrijft naar het effect van een bewegingsprogramma bij personen met type 2 diabetes.
openaire   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

MANAGEMENT OF TYPE 2 DIABETES

Health Problems of Civilization
Type 2 diabetes mellitus (T2DM) is the more common form of diabetes, characterized by insulin resistance and reduced insulin secretion; this occurs during the progression of T2DM, and high blood glucose levels.
Maitham Abdallah Albajy, Dan Florin Mihailescu   +1 more
doaj   +1 more source