Results 61 to 70 of about 101,972,677 (301)

Type 2 diabetes mellitus and gout

Научно-практическая ревматология, 2021
Gout is the most common inflammatory arthritis in adults and has continued to increase in prevalence over the past decades. Gout is characterized by hyperuricemia with the obligatory crystallization of urates and an associated inflammatory reaction, as ...
O. V. Zhelyabina, M. S. Eliseev
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Rab4b controls hepatic glucose production during fasting through glycophagy

Nature Communications
Hepatic glucose production, essential for maintaining glycemia, is often altered in metabolic-associated fatty liver and glycogen storage diseases. Therefore, understanding the mechanisms that regulate the glucose production by hepatocyte is pivotal ...
Marion Dussot, Lucie Le Parc, Sihame Sabbane, Alycia Zedda, Abderrahman Chafik, Alexandre Gallerand, Karine Dumas, Stéphanie Bonnafous, Yun Kwon, Sandra Lacas-Gervais, Charlotte Hinault Boyer, Giulia Chinetti, Sophie Giorgetti-Peraldi, Philippe Gual, Stoyan Ivanov, Anja Zeigerer, Jean-François Tanti, Mireille Cormont, Jerome Gilleron   +18 more
doaj   +1 more source

Prevalence of lean type 2 diabetes mellitus in recently diagnosed type 2 diabetes mellitus patients

Indian Journal of Endocrinology and Metabolism, 2013
Introduction: Obesity has always been thought to be a risk factor for diabetes; however, some studies in India have reported that even lean people are prone to diabetes.
Prateek Chaudhary, Demitrost Laloo, Ranabir Salam   +2 more
doaj   +1 more source

High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects [PDF]

, 2012
OBJECTIVE-To evaluate the changes in circulating endotoxin after a high-saturated fat meal to determine whether these effects depend on metabolic disease state.
Varma, M.C., Saravanan, Ponnusamy, Saravanan, P., Tripathi, Gyanendra, Kumar, Sudhesh, Sabico, Shaun, Sabico, S., O'Hare, J.P., McTernan, P. G., Harte, A. L., Varma, Madhusudhan C., Ceriello, A., Al-Attas, Omar S., McTernan, P.G., Al-Attas, O.S., Al-Daghri, Nasser M., Ceriello, Antonio, McGee, K. C., O'Hare, J. Paul, McGee, K.M., Al-Daghri, N.M., Kumar, S., Harte, A.L., Tripathi, G.   +23 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

MANAGEMENT OF TYPE 2 DIABETES

Health Problems of Civilization
Type 2 diabetes mellitus (T2DM) is the more common form of diabetes, characterized by insulin resistance and reduced insulin secretion; this occurs during the progression of T2DM, and high blood glucose levels.
Maitham Abdallah Albajy, Dan Florin Mihailescu   +1 more
doaj   +1 more source

Simvastatin Use in Patients with Type 2 Diabetes Mellitus: The Effects on Oxidative Stress

Oman Medical Journal, 2015
Objectives: Studies have shown that people with type 2 diabetes mellitus (T2DM)may develop atherosclerosis due to the disturbance in oxidative control and progressive dyslipidemia.
Mohammad A. Abdelhussein, Ammar R. M. Rudha, Dina A. Jamil, Hayder A. Al-Aubaidy   +3 more
doaj   +1 more source

A model to estimate the lifetime health outcomes of patients with Type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS no. 68) [PDF]

, 2004
<i>Aims/hypothesis</i> The aim of this study was to develop a simulation model for Type 2 diabetes that can be used to estimate the likely occurrence of major diabetes-related complications over a lifetime, in order to calculate health ...
Stevenson, R.J., Briggs, AH, Farmer, A.J., Fenn, P., Stevens, RJ, Clarke, P.M., Fenn, P,, Fenn, P, Stevens, R.J., Stratton, I.M., Gray, A, Farmer, AJ, Stratton, IM, Holman, R, Matthews, D.R., Matthews, DR, Briggs, A., Clarke, PM, the UK Prospective Diabetes Study (UKPDS) Group, Gray, A.M., Holman, R.R.   +20 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source