Results 61 to 70 of about 1,627,676 (310)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Evidence review : liraglutide for the treatment of type 2 diabetes [PDF]

, 2011
This paper presents a summary of the evidence review group (ERG) report into the clinical effectiveness and cost-effectiveness of liraglutide in the treatment of type 2 diabetes mellitus, based upon the manufacturer’s submission to the National Institute
Cummins, E. (Ewen), Waugh, Norman, Shyangdan, D. (Deepson), Royle, Pamela, HASH(0x55a67fac50c0)   +4 more
core  

Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population [PDF]

, 2008
Background Recent studies have implicated variants of the transcription factor 7-like 2 (TCF7L2) gene in genetic susceptibility to type 2 diabetes mellitus in several different populations. The aim of this study was to determine whether variants of this
Barnett Anthony H, Barnett, Anthony, Britten, Abigail C., Bellary, S, Barnett, Anthony H., Anthony H Barnett, Kumar Sudhesh, Britten, Abigail, Sudhesh Kumar, Rees, Simon D., Rees, Simon, Kelly, M. Ann, Kelly, Marilyn, Britten Abigail C, Kelly M Ann, Bellary, Srikanth, Rees Simon D, Srikanth Bellary, Abigail C Britten, J Paul O'Hare, Bellary Srikanth, O'Hare, JP, Kumar, Sudhesh, Simon D Rees, Barnett, A. H., O'Hare J Paul, Kumar, S, O'Hare, J. Paul, M Ann Kelly   +28 more
core   +1 more source

Exercise and type 2 diabetes [PDF]

, 2021
Proefschrift dat onder andere een tweejarig interventie-onderzoek beschrijft naar het effect van een bewegingsprogramma bij personen met type 2 diabetes.
openaire   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Identification of Type 1 Diabetes-Associated DNA Methylation Variable Positions That Precede Disease Diagnosis [PDF]

, 2011
Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is similar to 50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease.
Busato, F, Manfras, B, Kerith-rae M, Leslie, R. David, Jörg Tost, Manfras Burkhard, Mohammed I Hawa, Thomas A. Down, Maslau, S, Leslie, RD, Mohammed I. Hawa, Bernhard O Boehm, Beck Stephan, Rakyan, VK, Aden Deeqo, Daunay, A, Maslau Siarhei, Down Thomas A., Dias, Kerith-Rae M., Bell, Christopher G., Rakyan, Vardhman K., Boehm, Bernhard O., Beck, S, Bell Christopher G., Leslie R. David, Charles A. Mein, Charles A Mein, Boehm Bernhard O., Vardhman K Rakyan, Beyan, H, Burkhard Manfras, Christopher G. Bell, Hawa, MI, Kerith-Rae M. Dias, Vardhman K. Rakyan, R David Leslie, Kerith-Rae M Dias, Siarhei Maslau, Hawa Mohammed I., Busato Florence, Deeqo Aden, Bell, CG, Beck, Stephan, Stephan Beck, Bernhard O. Boehm, Busato, Florence, Dias Kerith-Rae M., Tost Jörg, Mein, Charles A., Christopher G Bell, Dias, KRM, Tost, J, Maslau, Siarhei, Hawa, Mohammed I., Daunay, Antoine, R. David Leslie, Florence Busato, Down, Thomas A., Rakyan Vardhman K., Tost, Jörg, Mein, CA, Daunay Antoine, Beyan, Huriya, Down, TA, Boehm, BO, Huriya Beyan, Antoine Daunay, Mein Charles A., Manfras, Burkhard, Thomas A Down, Beyan Huriya, Aden, D, Aden, Deeqo   +72 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Genes and type 2 diabetes: polymorphisms of the EIF2AK3 gene and its relationship to type 2 diabetes mellitus [PDF]

, 2010
MDAims/ Hypothesis: Wolcott- Rallison syndrome (WRS) is a rare autosomal recessively inherited Mendelian disorder. It is characterised by a short trunk compared to arm span, multiple epiphyseal dysplasia, multiple fractures, hepatosplenomegaly and renal ...
Sudagani, Jaidev
core  

A model to estimate the lifetime health outcomes of patients with Type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS no. 68) [PDF]

, 2004
<i>Aims/hypothesis</i> The aim of this study was to develop a simulation model for Type 2 diabetes that can be used to estimate the likely occurrence of major diabetes-related complications over a lifetime, in order to calculate health ...
Stevenson, R.J., Gray, Alastair, Stevens, Richard, Briggs, AH, Holman, RR, Farmer, A.J., Holman, Rury, Fenn, P., Stevens, RJ, Clarke, P.M., Fenn, P,, Fenn, P, Stevens, R.J., Stratton, I.M., Farmer, Andrew, Gray, A, Gray, AM, Farmer, AJ, Stratton, IM, Holman, R, Matthews, D.R., Matthews, DR, Briggs, A., Clarke, PM, Briggs, A, the UK Prospective Diabetes Study (UKPDS) Group, Gray, A.M., Holman, R.R.   +27 more
core   +1 more source