Results 241 to 250 of about 32,144 (301)

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson, Nikolai B. Nordsborg   +1 more
wiley   +1 more source

Suppression of Cytosolic Phospholipase A2 in the Ventromedial Hypothalamus Induces Hyperphagia and Obesity in Male Mice. [PDF]

Int J Mol Sci
Abe T, Ishimoto T, Araki Y, Niu Z, Li C, He J, Ngurari S, Toda C.   +7 more
europepmc   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Virulence and Resistance of <i>Pseudomonas aeruginosa</i> Isolated from Poultry in Brazil. [PDF]

Microorganisms
Barbosa FB, Pons MJ, Ruiz J, Sáenz Y, Christensen H, Knöbl T.   +5 more
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Avian Candidiasis: A Comprehensive Review of Pathogenesis, Diagnosis, and Control. [PDF]

Vet Sci
Haroun M, Tratrat C, Mathew RT, Munir M, Sattar MN, Shawky M, Kochkar H, Aldakhilallah ON, Ghafoor A, Turk KGB, Geronikaki A, Ghazzawy HS.   +11 more
europepmc   +1 more source

Pathogenic rickettsiae encode a secreted lipase that facilitates intracytosolic colonization in host cells. [PDF]

PLoS One
Sadik M, Moin I, Ullah S, Krusenstjerna AC, Gonin M, Goley ED, Rahman MS, Voss OH.   +7 more
europepmc   +1 more source

Assessing the Utility of Broad-Acting Inhibitors as Therapeutics in Diverse Venoms. [PDF]

Toxins (Basel)
Kadler R, Morrison B, Yanagihara AA.
europepmc   +1 more source

Brown Spider Venom Phospholipases D: From Potent Molecules Involved in Pathogenesis of Brown Spider Bites to Molecular Tools for Studying Ectosomes, Ectocytosis, and Its Applications. [PDF]

Toxins (Basel)
Wille ACM, Machado MI, Souza SH, Justa HCD, Fraga-Ferreira ME, Mello ES, Gremski LH, Veiga SS.   +7 more
europepmc   +1 more source