Results 251 to 260 of about 533,494 (308)

The mood stabilizers lithium and valproate disrupt hepatic and intestinal farnesoid X receptor signalling and increase bile synthesis in the rat

Experimental Physiology, EarlyView.
Abstract The mood stabilizers lithium and valproate are psychotropic medications widely used in clinical practice. Despite their proven benefits, many individuals stop their treatment due to the adverse effects. Chronic diarrhoea is a common reason for discontinuation of these drugs; however, the underlying mechanisms are unknown.
Sofia Cussotto, Anna V. Golubeva, Alvaro Lopez Gallardo, Thomaz F. S. Bastiaanssen, Alexander V. Zhdanov, Gerard M. Moloney, Caitriona Scaife, Jane A. English, Susan A. Joyce, Timothy G. Dinan, John F. Cryan   +10 more
wiley   +1 more source

Electrical Cell Impedance Sensing (ECIS): Feasibility of a Novel In Vitro Approach to Studying Venom Toxicity and Potential Therapeutics. [PDF]

Toxins (Basel)
Choudhury A, Linne K, Bulfone TC, Hossain T, Sina AA, Bickler PL, Fry BG, Lewin MR.   +7 more
europepmc   +1 more source

Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm, Neha Gupta, Alexandru Mircea, Caoimhin S. Griffin   +3 more
wiley   +1 more source

ERLNs augment simultaneous delivery of GFSV into PC-3 cells: Influence of drug combination on SDH, GPX-4, 5α-RD, and cytotoxicity. [PDF]

Oncol Res
Alzhrani RF, Binobaid L, Aloraini AA, Alsahli MS, Bakheit AH, Asiri HH, Attia SM, Alhoshani A, Harisa GI.   +8 more
europepmc   +1 more source

Recent advances in the structure, function and regulation of the volume‐regulated anion channels and their role in immunity

The Journal of Physiology, EarlyView.
Abstract figure legend The volume‐regulated anion channel (VRAC), composed of leucine‐rich repeat‐containing 8 (LRRC8) proteins, serves both canonical and non‐canonical functions in vertebrate cells. The canonical function of this channel relates to its original description, which is homeostatic regulation of cell volume in response to hypotonic ...
Sergei Yanushkevich, Aleksandra Zieminska, Joshua Gonzalez, Francisca Añazco, Richard Song, Alejandra Arias‐Cavieres, Sara T. Granados, Junyi Zou, Yan Rao, Axel R. Concepcion   +9 more
wiley   +1 more source

Bites and Stings: Exotic Causes of Stroke in Asia. [PDF]

Cerebrovasc Dis Extra
Ranawaka UK.
europepmc   +1 more source

Sphingosine‐1‐phosphate activates LRRC8 volume‐regulated anion channels through Gβγ signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sphingosine‐1‐phosphate (S1P) binds to Gi protein‐coupled receptor S1PR1. Upon S1PR1 activation, Gβγ is released from the Gαi‐Gβγ heterotrimer, allowing it to recruit phospholipase Cβ (PLCβ) to the plasma membrane. PLCβ cleaves phosphatidylinositol‐4,5‐bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG).
Yulia Kostritskaia, Sumaira Pervaiz, Anna Klemmer, Malte Klüssendorf, Tobias Stauber   +4 more
wiley   +1 more source

Inducible expression of DEFECTIVE IN ANTHER DEHISCENCE 1 enhances triacylglycerol accumulation and lipid droplet formation in vegetative tissues. [PDF]

Plant J
Kimberlin AN, Mahmud S, Holtsclaw RE, Walker A, Conrad K, Morley SA, Welti R, Allen DK, Koo AJ.   +8 more
europepmc   +1 more source

Mitochondria regulate inositol triphosphate‐mediated Ca2+ release triggered by voltage‐dependent Ca2+ entry in resistance arteries

The Journal of Physiology, EarlyView.
Abstract figure legend Proposed mechanism of regulation of mitochondria on VDCCs mediated Ca2+ signals in smooth muscle cells. Depolarization of the plasma membrane induces Ca2+ influx via L‐type VDCCs that produces a steady elevation in Ca2+ and activates IP3Rs to evoke repetitive Ca2+ release events from the intracellular Ca2+ store.
Xun Zhang, Charlotte Buckley, Matthew D. Lee, Susan Chalmers, Calum Wilson, John G. McCarron   +5 more
wiley   +1 more source

Proteomic Analysis and Biochemical Characterization of the Nematocyst Extract of the Hydrozoan Velella velella. [PDF]

Mar Drugs
Tassara E, Mikšík I, Pompach P, Mariottini GL, Xiao L, Giovine M, Pozzolini M.   +6 more
europepmc   +1 more source