Results 261 to 270 of about 32,144 (301)

A Bacterial-Toxin Type of Phospholipase (Lecithinase C) in a Marine Phytoplanktonic Chrysomonad

Journal of the Fisheries Research Board of Canada, 1967
not available
N. J. Antia, E. Bilinski
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Effects of selective phosphodiesterase type IV inhibitor, rolipram, on signal transducing phospholipases in neutrophil: Inhibition of phospholipases A2, D but not C

Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 1995
The effects of a selective phosphodiesterase (PDE) type IV inhibitor, rolipram, on activation of neutrophil phospholipases in response to the chemotactic peptide formyl-methiony-leucyl-phenylalanine (fMLP) were investigated. fMLP caused liberation of arachidonic acid, a precursor of eicosanoids and in the presence of 0.3% butanol, production of ...
S, Nakashima, T, Mizutani, Y, Nakamura, S O, Takemura, M, Nakamura, H, Miyata, Y, Katagiri, Y, Nozawa   +7 more
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Purification of recombinant SH2SH3 proteins of phospholipase C-γ1 and -γ2 and their inhibitory effect on PIP2-hydrolysis induced by both types of phospholipase C-γ

Biochemical and Biophysical Research Communications, 1992
In order to examine physiological function of the SH2/SH3 region of phospholipase C-gamma (Z region), we independently expressed cDNA fragments corresponding to the SH2/SH3 region of PLC-gamma 1 and PLC-gamma 2 in Escherichia coli. Although these recombinant proteins were recovered in particulate fractions by centrifugation of cell extracts, they were ...
Y, Homma, Y, Emori, T, Takenawa
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Humoral and Delayed-type Hypersensitive Responses againstListeria monocytogenes Phosphatidylinositol-specific Phospholipase C in Experimentally Infected Buffaloes

Veterinary Research Communications, 2004
The kinetics of antibody production against phosphatidylinositol-specific phospholipase C (PI-PLC) and the isolation pattern of Listeria monocytogenes from bacteriological samples were studied following oral infection of buffalo calves with 3 x 10(9) cells each of pathogenic L. monocytogenes. Antibodies to PI-PLC appeared by 4-8 days post infection (PI)
S P, Chaudhari, S V S, Malik, S B, Barbuddhe   +2 more
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Significance of nuclear phospholipase C signaling through type 1 IGF receptor.

Journal of endocrinological investigation, 2004
The existence of a nuclear polyphosphoinositol metabolism independent from that at the plasma membrane is now widely recognized. Specific changes in the nuclear phosphatidylinositol (Ptdlns) metabolism have been implicated in cell growth, differentiation, and neoplastic transformation.
COCCO, LUCIO ILDEBRANDO, S. Capitani, MARALDI, NADIR, MARTELLI, ALBERTO MARIA, MAZZOTTI, GIOVANNI, MANZOLI, FRANCESCO ANTONIO   +5 more
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Identification of phosphatidylinositol‐specific phospholipase C activity in Listeria monocytogenes: a novel type of virulence factor?

Molecular Microbiology, 1991
SummaryA phospholipase C which cleaves phosphatidylinositol and glycosylphosphatidylinositol (GPI) anchors was identified in Listeria monocytogenes. This 36kDa protein is encoded by the gene plcA, and is homologous to the Bacillus cereus, Bacillus thuringiensis and eukaryotic phosphatidylinositol‐specific phospholipases C (PI‐PLC).
J, Mengaud, C, Braun-Breton, P, Cossart
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The Promoter Activity of the Phospholipase C-γ2 Gene Is Regulated by a Cell-Type-Specific Control Element

DNA and Cell Biology, 1997
We have cloned and characterized a genomic DNA spanning the 5'-flanking region, the first and second exons, and the first intron of the human PLC-gamma2 gene. The proximal upstream region is highly GC-rich and lacks a TATA box, whereas the distal region contains several AT-rich tracts.
Lee, SJ, Bahk, YY, Yun, DH, Lee, HJ, Lee, YH, Ryu, SH, Suh, PG   +6 more
openaire   +3 more sources

Phospholipase C from Clostridium novyi type A. II. Factors influencing the enzyme activity.

Journal of biochemistry, 1978
The apparent activity of phospholipase C[EC 3.1.4.3] of Clostridium novyi type A toward phosphatidylcholine, sphingomyelin, and phosphatidylethanolamine increased in the presence of sodium deoxycholate (SDC). The effects of divalent cations on phospholipase C activity were examined in detail at various concentrations of these cations.
R, Taguchi, H, Ikezawa
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Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway

The FASEB Journal, 2013
As shown in a large clinical prospective trial, inhibition of the renin‐angiotensin system (RAS) can delay the onset of type 2 diabetes in high‐risk individuals. We evaluated the beneficial effects of RAS inhibition on β‐cell function under glucotoxic conditions.
Madec, Anne‐marie, Cassel, Roméo, Dubois, Séverine, Ducreux, Sylvie, Vial, Guillaume, Chauvin, Marie‐agnès, Mesnier, Aurélia, Chikh, Karim, Bosco, Domenico, Rieusset, Jennifer, van Coppenolle, Fabien, Thivolet, Charles   +11 more
openaire   +5 more sources

The Small GTPase Ral Couples the Angiotensin II Type 1 Receptor to the Activation of Phospholipase C-δ1

Molecular Pharmacology, 2010
The angiotensin II type 1 receptor (AT(1)R) plays an important role in cardiovascular function and as such represents a primary target for therapeutic intervention. The AT(1)R has traditionally been considered to be coupled to the activation of phospholipase C (PLC) beta via its association with G alpha(q/11), leading to increases in intracellular ...
Christina M, Godin, Lucimar T, Ferreira, Lianne B, Dale, Robert, Gros, Sean P, Cregan, Stephen S G, Ferguson   +5 more
openaire   +2 more sources