Results 271 to 280 of about 32,144 (301)

Arachidonic acid metabolism via cytosolic phospholipase A₂α induces cytotoxicity in niemann–pick disease type C cells

Journal of Cellular Physiology, 2012
AbstractNiemann–Pick disease type C (NPC) is a neurodegenerative lipid storage disorder caused by mutations in NPC1 or NPC2 genes. Loss of function of either protein results in the endosomal accumulation of cholesterol and other lipids. Here, we report that NPC1‐deficient Chinese hamster ovary cells exhibit increased release of arachidonic acid (AA ...
Hiroyuki, Nakamura, Kana, Yasufuku, Tomohiko, Makiyama, Ikiru, Matsumoto, Hiromichi, Fujino, Toshihiko, Murayama   +5 more
openaire   +2 more sources

Phospholipase C δ-type consists of three isozymes: bovine PLCδ2 is a homologue of human/mouse PLCδ4

Biochemical and Biophysical Research Communications, 2004
Abstract To date, 12 phospholipase C (PLC) isozymes have been identified in mammals, and they are divided into five classes, β-, γ-, δ-, e-, and ζ-type. PLCδ-type is reported to be composed of four isozymes, PLCδ1–δ4. Here we report that a screening for mouse PLCδ2 from a BAC library with primers that amplify a specific region of bovine PLCδ2 ...
Yasuhiro Irino, Hiroyuki Cho, Yoshikazu Nakamura, Masamichi Nakahara, Masahiro Furutani, Pann-Ghill Suh, Tadaomi Takenawa, Kiyoko Fukami   +7 more
openaire   +1 more source

Physiological functions of phospholipase C δ-type

Advances in Enzyme Regulation, 2008
Kiyoko, Fukami, Manabe, Ichinohe, Masayuki, Hirata, Yoshikazu, Nakamura   +3 more
openaire   +2 more sources

Nuclear phospholipase C signaling through type 1 IGF receptor and its involvement in cell growth and differentiation.

Anticancer research, 2005
The existence of a nuclear polyphosphoinositol metabolism, independent from that at the plasma cell membrane, is now widely recognized. Specific changes in the nuclear phosphatidylinositol (PtdIns) metabolism have been implicated in cell growth, differentiation and neoplastic transformation.
FAENZA, IRENE, BILLI, ANNA MARIA, FOLLO, MATILDE YUNG, FIUME, ROBERTA, MARTELLI, ALBERTO MARIA, COCCO, LUCIO ILDEBRANDO, MANZOLI, LUCIA   +6 more
openaire   +2 more sources

Studies on phosphatidylinositol phosphodiesterase (phospholipase C type) of Bacillus cereus

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1976
Ikezawa Hiroh, Yamanegi Masato, Taguchi Ryo, Miyashita Tomoyuki, Ohyabu Tetsuo   +4 more
openaire   +1 more source

Studies on phosphatidylinositol phosphodiesterase (phospholipase C type) of Bacillus cereus

Archives of Biochemistry and Biophysics, 1978
Tetsuo Ohyabu, Ryo Taguchi, Hiroh Ikezawa   +2 more
openaire   +1 more source

Molecular Aggregation between a Phosphatidylinositol-Specific Phospholipase C-Type Enzyme and Microtubules

Biochemical Society Transactions, 1973
P. J. QUINN, NORBERT FREINKEL
openaire   +1 more source

Coupling between L-type calcium channels and phospholipase C in muscle cells

Journal of Physiology-Paris, 2006
José Miguel Eltit, Jorge Hidalgo, César Cárdenas, A. Lejandra García, José Luis Liberona, Enrique Jaimovich   +5 more
openaire   +1 more source

Signaling and transduction mechanism of phospholipase C and isoforms in different cell types

2023
J.R. Yodhaanjali, Kanthesh M. Basalingappa, T.S. Gopenath, Shiva Siddappa   +3 more
openaire   +1 more source

Type 2 chronic inflammatory diseases: targets, therapies and unmet needs

Nature Reviews Drug Discovery, 2023
P V Kolkhir, Thomas Bieber, E Guttman-Yassky   +2 more
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