Results 301 to 310 of about 32,298 (336)

Significance of nuclear phospholipase C signaling through type 1 IGF receptor.

Journal of endocrinological investigation, 2004
The existence of a nuclear polyphosphoinositol metabolism independent from that at the plasma membrane is now widely recognized. Specific changes in the nuclear phosphatidylinositol (Ptdlns) metabolism have been implicated in cell growth, differentiation, and neoplastic transformation.
COCCO, LUCIO ILDEBRANDO, S. Capitani, MARALDI, NADIR, MARTELLI, ALBERTO MARIA, MAZZOTTI, GIOVANNI, MANZOLI, FRANCESCO ANTONIO   +5 more
openaire   +5 more sources

Identification of phosphatidylinositol‐specific phospholipase C activity in Listeria monocytogenes: a novel type of virulence factor?

Molecular Microbiology, 1991
SummaryA phospholipase C which cleaves phosphatidylinositol and glycosylphosphatidylinositol (GPI) anchors was identified in Listeria monocytogenes. This 36kDa protein is encoded by the gene plcA, and is homologous to the Bacillus cereus, Bacillus thuringiensis and eukaryotic phosphatidylinositol‐specific phospholipases C (PI‐PLC).
J, Mengaud, C, Braun-Breton, P, Cossart
openaire   +2 more sources

The Promoter Activity of the Phospholipase C-γ2 Gene Is Regulated by a Cell-Type-Specific Control Element

DNA and Cell Biology, 1997
We have cloned and characterized a genomic DNA spanning the 5'-flanking region, the first and second exons, and the first intron of the human PLC-gamma2 gene. The proximal upstream region is highly GC-rich and lacks a TATA box, whereas the distal region contains several AT-rich tracts.
Lee, SJ, Bahk, YY, Yun, DH, Lee, HJ, Lee, YH, Ryu, SH, Suh, PG   +6 more
openaire   +3 more sources

Phospholipase C from Clostridium novyi type A. II. Factors influencing the enzyme activity.

Journal of biochemistry, 1978
The apparent activity of phospholipase C[EC 3.1.4.3] of Clostridium novyi type A toward phosphatidylcholine, sphingomyelin, and phosphatidylethanolamine increased in the presence of sodium deoxycholate (SDC). The effects of divalent cations on phospholipase C activity were examined in detail at various concentrations of these cations.
R, Taguchi, H, Ikezawa
openaire   +1 more source

Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway

The FASEB Journal, 2013
As shown in a large clinical prospective trial, inhibition of the renin‐angiotensin system (RAS) can delay the onset of type 2 diabetes in high‐risk individuals. We evaluated the beneficial effects of RAS inhibition on β‐cell function under glucotoxic conditions.
Madec, Anne‐marie, Cassel, Roméo, Dubois, Séverine, Ducreux, Sylvie, Vial, Guillaume, Chauvin, Marie‐agnès, Mesnier, Aurélia, Chikh, Karim, Bosco, Domenico, Rieusset, Jennifer, van Coppenolle, Fabien, Thivolet, Charles   +11 more
openaire   +5 more sources

The Small GTPase Ral Couples the Angiotensin II Type 1 Receptor to the Activation of Phospholipase C-δ1

Molecular Pharmacology, 2010
The angiotensin II type 1 receptor (AT(1)R) plays an important role in cardiovascular function and as such represents a primary target for therapeutic intervention. The AT(1)R has traditionally been considered to be coupled to the activation of phospholipase C (PLC) beta via its association with G alpha(q/11), leading to increases in intracellular ...
Christina M, Godin, Lucimar T, Ferreira, Lianne B, Dale, Robert, Gros, Sean P, Cregan, Stephen S G, Ferguson   +5 more
openaire   +2 more sources

Arachidonic acid metabolism via cytosolic phospholipase A₂α induces cytotoxicity in niemann–pick disease type C cells

Journal of Cellular Physiology, 2012
AbstractNiemann–Pick disease type C (NPC) is a neurodegenerative lipid storage disorder caused by mutations in NPC1 or NPC2 genes. Loss of function of either protein results in the endosomal accumulation of cholesterol and other lipids. Here, we report that NPC1‐deficient Chinese hamster ovary cells exhibit increased release of arachidonic acid (AA ...
Hiroyuki, Nakamura, Kana, Yasufuku, Tomohiko, Makiyama, Ikiru, Matsumoto, Hiromichi, Fujino, Toshihiko, Murayama   +5 more
openaire   +2 more sources

Phospholipase C δ-type consists of three isozymes: bovine PLCδ2 is a homologue of human/mouse PLCδ4

Biochemical and Biophysical Research Communications, 2004
Abstract To date, 12 phospholipase C (PLC) isozymes have been identified in mammals, and they are divided into five classes, β-, γ-, δ-, e-, and ζ-type. PLCδ-type is reported to be composed of four isozymes, PLCδ1–δ4. Here we report that a screening for mouse PLCδ2 from a BAC library with primers that amplify a specific region of bovine PLCδ2 ...
Yasuhiro Irino, Hiroyuki Cho, Yoshikazu Nakamura, Masamichi Nakahara, Masahiro Furutani, Pann-Ghill Suh, Tadaomi Takenawa, Kiyoko Fukami   +7 more
openaire   +1 more source

Physiological functions of phospholipase C δ-type

Advances in Enzyme Regulation, 2008
Kiyoko, Fukami, Manabe, Ichinohe, Masayuki, Hirata, Yoshikazu, Nakamura   +3 more
openaire   +2 more sources

Nuclear phospholipase C signaling through type 1 IGF receptor and its involvement in cell growth and differentiation.

Anticancer research, 2005
The existence of a nuclear polyphosphoinositol metabolism, independent from that at the plasma cell membrane, is now widely recognized. Specific changes in the nuclear phosphatidylinositol (PtdIns) metabolism have been implicated in cell growth, differentiation and neoplastic transformation.
FAENZA, IRENE, BILLI, ANNA MARIA, FOLLO, MATILDE YUNG, FIUME, ROBERTA, MARTELLI, ALBERTO MARIA, COCCO, LUCIO ILDEBRANDO, MANZOLI, LUCIA   +6 more
openaire   +2 more sources