Results 71 to 80 of about 707 (287)

Hydrolysis of surfactant-associated phosphatidylcholine by mammalian secretory phospholipases A₂

, 1998
Hydrolysis of surfactant-associated phospholipids by secretory phospholipases A2is an important potential mechanism for surfactant dysfunction in inflammatory lung diseases.
Moseley Waite, R. Duncan Hite, Randy B. Jacinto, R. Balasubramanian, David Bass, Michael C. Seeds   +5 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Noninvasive tests for nonalcoholic fatty liver disease in a multi‐ethnic population: The HELIUS study

Hepatology Communications, EarlyView., 2022
Abstract Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence and severity globally, prompting noninvasive testing, yet limited data exist on noninvasive liver tests (NITs) including transient elastography (TE) in ethnically diverse populations.
Anne‐Marieke van Dijk, Yasaman Vali, Anne Linde Mak, Henrike Galenkamp, Max Nieuwdorp, Bert‐Jan van den Born, Adriaan Georgius Holleboom   +6 more
wiley   +1 more source

Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicans

, 2005
Phospholipases C are known to be important regulators of cellular processes but may also act as virulence factors of pathogenic microbes. At least three genes in the genome of the human-pathogenic fungus Candida albicans encode phospholipases with ...
Bennett, D., Odds, F. C., Coleman, D. C., Melzer, I., Schafer, W., Hube, B., Sanglard, D., Norskau, J., Kunze, D., MacCallum, D.   +9 more
core   +1 more source

Secreted phospholipases A2 in hereditary angioedema with C1-inhibitor deficiency [PDF]

, 2018
BackgroundHereditary angioedema (HAE) caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein (C1-INH-HAE) is a disabling, potentially fatal condition characterized by recurrent episodes of swelling. We have recently found that
Maria Bova, Marone, Gianni, Gilda Varricchi, Cicardi, Marco, Suffritti C., Chiara Suffritti, Borriello F., Galdiero, Maria Rosaria, Bova, Maria, Marco Cicardi, Borriello, Francesco, Francesco Borriello, Angelica Petraroli, Varricchi, Gilda, Galdiero M. R., Anne Lise Ferrara, Veszeli N., Loffredo, Stefania, Loffredo S., Gérard Lambeau, Granata, Francescopaolo, Lambeau, Gérard, Farkas, Henriette, Nóra Veszeli, Petraroli, Angelica, Granata F., Suffritti, Chiara, Zanichelli, Andrea, Francescopaolo Granata, Henriette Farkas, Petraroli A., Veszeli, Nóra, Stefania Loffredo, Varricchi G., Maria Rosaria Galdiero, Marone G., Ferrara A. L., Farkas H., Andrea Zanichelli, Ferrara, Anne Lise, Gianni Marone, Bova M., Zanichelli A., Cicardi M., Lambeau G.   +44 more
core   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Leucocyte recruitment induced by type II phospholipases A(2) into the rat pleural cavity

, 2015
FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOBothropstoxin-I (BthTX-I) and bothropstoxin-II (BthTX-II) are Lys-49 and Asp-49 phospholipases A(2) (PLA(2)s), respectively, isolated from Bothrops jararacussu venom.
Toyama, M.H., Landucci, E C, Landucci, E.C.T., Castro, R.C. de, Giglio, J.R., Antunes, E, De Nucci, G., de Castro, R C, Antunes, E., Giglio, J R, Marangoni, S., Marangoni, S, Toyama, M H, De Nucci, G   +13 more
core   +2 more sources

Small peptides do not inhibit human non-pancreatic secretory phospholipase-A 2 (Type IIA)

, 2000
Seven small peptides, that are among the most potent reported inhibitors of secreted mammalian phospholipases A(2), were found not to inhibit processing of a small phospholipid substrate by human nonpancreatic secretory phospholipase A(2) (type IIa ...
Clark, C. I., Reid, R. C., McGeary, R. P., Schafer, K., Fairlie, D. P.   +4 more
core   +1 more source

Legionella pneumophila pathogenesis : establishment of a new insect infection model and characterisation of the effector protein LtpD [PDF]

, 2013
Legionella pneumophila is the causative agent of Legionnaires’ disease, severe pneumonia acquired from inhalation of contaminated water droplets. In the lung, L.
Harding, Clare R.
core   +1 more source