Results 181 to 190 of about 1,118,779 (342)

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

A type III secretion system is required for Bordetella atropi invasion of host cells in vivo. [PDF]

PLoS Pathog
Tran TD, Meadows-Graves SJ, Haio AR, Varga AI, Luallen RJ.   +4 more
europepmc   +1 more source

Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion

Clinical Microbiology Reviews, 2008
Gunnar N. Schroeder, H. Hilbi
semanticscholar   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Medium dependent factors govern the functionality of engineered type III secretion systems. [PDF]

J Biol Eng
Yi S, Kim BS, Choi E, Lee EJ, Kim J.
europepmc   +1 more source

Type III Secretion System [PDF]

, 2008
openaire   +1 more source

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, EarlyView.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

Effector-host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation. [PDF]

Nat Microbiol
Young V, Dohai B, Halder H, Fernandez-Macgregor J, van Heusden NS, Hitch TCA, Weller B, Hyden P, Saha D, Pieren DKJ, Rittchen S, Lambourne L, Maseko SB, Lin CW, Tun YM, Bibus J, Pletschacher L, Boujeant M, Choteau SA, Bergogne L, Perrin J, Ober F, Schwehn P, Rothballer ST, Altmann M, Altmann S, Strobel A, Rothballer M, Tofaute M, Kotlarz D, Heinig M, Clavel T, Calderwood MA, Vidal M, Twizere JC, Vincentelli R, Krappmann D, Boes M, Falter C, Rattei T, Brun C, Zanzoni A, Falter-Braun P.   +42 more
europepmc   +1 more source

Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation.

Proceedings of the National Academy of Sciences of the United States of America, 1995
K. Jarvis, J. Girón, A. Jerse, T. McDaniel, M. Donnenberg, J. Kaper   +5 more
semanticscholar   +1 more source