Bridging the Gap: Type III Secretion Systems in Plant-Beneficial Bacteria [PDF]
Microorganisms, 2022 Type III secretion systems (T3SSs) are bacterial membrane-embedded nanomachines translocating effector proteins into the cytoplasm of eukaryotic cells.
Antoine Zboralski +2 more
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Translation/Secretion Coupling by Type III Secretion Systems [PDF]
Cell, 2000 Type III secretion systems mediate export of virulence proteins and flagellar assembly subunits in Gram-negative bacteria. Chaperones specific to each class of secreted protein are believed to prevent degradation of the secreted substrates. We show that an additional role of chaperones may be to regulate translation of secreted proteins.
Kelly Hughes +2 more
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Special Issue: Type III Secretion Systems in Human/Animal Pathogenic Bacteria [PDF]
Microorganisms, 2022 Type III secretion systems (T3SSs) are molecular devices that are essential for the communication of many Gram-negative bacteria with their eukaryotic hosts [...]
Joaquín Bernal-Bayard +1 more
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The Structure and Function of Type III Secretion Systems. [PDF]
Microbiol Spectr, 2016 ABSTRACT Type III secretion systems (T3SSs) afford Gram-negative bacteria an intimate means of altering the biology of their eukaryotic hosts—the direct delivery of effector proteins from the bacterial cytoplasm to that of the eukaryote. This incredible biophysical feat is accomplished by nanosyringe “injectisomes,” which form a conduit ...
Notti RQ, Stebbins CE.
europepmc +4 more sources
Cryo-EM of the injectisome and type III secretion systems. [PDF]
Curr Opin Struct Biol, 2022 Double-membrane-spanning protein complexes, such as the T3SS, had long presented an intractable challenge for structural biology. As a consequence, until a few years ago, our molecular understanding of this fascinating complex was limited to composite models, consisting of structures of isolated domains, positioned within the overall complex.
Bergeron JRC, Marlovits TC.
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Type III secretion systems and disease. [PDF]
Clin Microbiol Rev, 2007 SUMMARY Type III secretion systems (T3SSs) are complex bacterial structures that provide gram-negative pathogens with a unique virulence mechanism enabling them to inject bacterial effector proteins directly into the host cell cytoplasm, bypassing the extracellular milieu.
Coburn B, Sekirov I, Finlay BB.
europepmc +4 more sources
Morphogenetic penicillin-binding proteins control virulence-associated type III secretion systems in Salmonella [PDF]
Infection and ImmunityType III protein secretion systems (T3SSs) function as multiprotein devices that span the envelope of Gram-negative bacteria using the peptidoglycan (PG) layer as scaffold.
Sónia Castanheira +3 more
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Medium dependent factors govern the functionality of engineered type III secretion systems [PDF]
Journal of Biological EngineeringBackground The type III secretion system (T3SS) is a syringe-like machine that pathogenic bacteria use to inject effector proteins into host cells.
SangKu Yi +4 more
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Identification of protein secretion systems and type III effectors in wood-associated bacteria of the genus Xylophilus [PDF]
Microbiology SpectrumTo gain insights into the biology of bacteria of the genus Xylophilus, including the grapevine pathogen Xylophilus ampelinus, we scrutinized all available genome sequences of the genus for the presence of type III secretion and flagellar systems.
Zoe Roux +4 more
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Monosodium Glutamate Inhibits Pseudomonas aeruginosa-Induced Acute Lung Injury by Targeting the Type III Secretion Systems and Modulating Host Immunity [PDF]
MicroorganismsThe opportunistic pathogen Pseudomonas aeruginosa poses a serious threat to immunocompromised patients. Monosodium glutamate (MSG), a widely used flavor enhancer, has been reported to possess anti-inflammatory and antioxidant properties.
Jing Xu +8 more
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