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Type III secretion system [PDF]
Current Biology, 2014 The type III secretion system (T3SS) is a membrane-embedded nanomachine found in several Gram-negative bacteria. Upon contact between bacteria and host cells, the syringe-like T3SS (Figure 1) transfers proteins termed effectors from the bacterial cytosol to the cytoplasm or the plasma membrane of a single target cell.
Puhar, Andrea, Sansonetti, Philippe J.
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Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells. [PDF]
Annu Rev Microbiol, 2014 Galán JE +3 more
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Adaptivity and dynamics in type III secretion systems [PDF]
Molecular Microbiology, 2020 AbstractThe type III secretion system is the common core of two bacterial molecular machines: the flagellum and the injectisome. The flagellum is the most widely distributed prokaryotic locomotion device, whereas the injectisome is a syringe‐like apparatus for inter‐kingdom protein translocation, which is essential for virulence in important human ...
Bailey Milne‐Davies +2 more
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Analysis of the expression, secretion and translocation of the Salmonella enterica type III secretion system effector SteA. [PDF]
PLoS ONE, 2011 Many Gram-negative pathogens possess virulence-related type III secretion systems. Salmonella enterica uses two of these systems, encoded on the pathogenicity islands SPI-1 and SPI-2, respectively, to translocate more than 30 effector proteins into ...
Elena Cardenal-Muñoz +1 more
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ATPase-independent type-III protein secretion in Salmonella enterica. [PDF]
PLoS Genetics, 2014 Type-III protein secretion systems are utilized by gram-negative pathogens to secrete building blocks of the bacterial flagellum, virulence effectors from the cytoplasm into host cells, and structural subunits of the needle complex.
Marc Erhardt +3 more
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Frontiers in Cellular and Infection Microbiology, 2023 Infections caused by Gram-negative pathogens pose a major health burden. Both respiratory and gastrointestinal infections are commonly associated with these pathogens.
Nadja Blasey +3 more
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Secretin interactions in the type II secretion system [PDF]
, 2012 PhDThe type II secretion system (T2SS) is the major terminal branch of the general secretory pathway. It is composed of 12-15 proteins, most in multiple copies, and spans the inner and outer membranes of Gram-negative bacteria.
Gu, Shuang
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The Missing Pieces: The Role of Secretion Systems in Campylobacter jejuni Virulence
Biomolecules, 2023 Campylobacter jejuni is likely the most common bacterial cause of gastroenteritis worldwide, responsible for millions of cases of inflammatory diarrhea characterized by severe abdominal cramps and blood in the stool. Further, C.
Amber D. Gabbert +7 more
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Heliyon, 2023 The Gram-negative bacterium Pseudomonas plecoglossicida has caused visceral granulomas disease in several farmed fish species, including large yellow croaker (Larimichthys crocea), which results in severe economic losses. Type III secretion systems (T3SS)
Pan Qin +8 more
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Genetics and Molecular Biology, 2005 The secretion of bacterial virulence factors and flagellar components requires the assistance of specific type III and flagellar chaperones. Standard computational annotation of the genome of Xanthomonas axonopodis pv citri, a plant pathogen that causes ...
Letícia Khater +5 more
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