The Architecture of the Cytoplasmic Region of Type III Secretion Systems. [PDF]
Sci Rep, 2016 AbstractType III secretion systems (T3SSs) are essential devices in the virulence of many Gram-negative bacterial pathogens. They mediate injection of protein effectors of virulence from bacteria into eukaryotic host cells to manipulate them during infection. T3SSs involved in virulence (vT3SSs) are evolutionarily related to bacterial flagellar protein
Makino F +9 more
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Primary architecture and energy requirements of Type III and Type IV secretion systems
Frontiers in Cellular and Infection Microbiology, 2023 Many pathogens use Type III and Type IV protein secretion systems to secrete virulence factors from the bacterial cytosol into host cells. These systems operate through a one-step mechanism. The secreted substrates (protein or nucleo-protein complexes in
Elena Cabezón +2 more
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Comparative Genomics Identifies a Novel Conserved Protein, HpaT, in Proteobacterial Type III Secretion Systems that Do Not Possess the Putative Translocon Protein HrpF [PDF]
Frontiers in Microbiology, 2017 Xanthomonas translucens is the causal agent of bacterial leaf streak, the most common bacterial disease of wheat and barley. To cause disease, most xanthomonads depend on a highly conserved type III secretion system, which translocates type III effectors
Céline Pesce +9 more
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The Structure of an Injectisome Export Gate Demonstrates Conservation of Architecture in the Core Export Gate between Flagellar and Virulence Type III Secretion Systems [PDF]
mBio, 2019 Export of proteins through type III secretion systems (T3SS) is critical for motility and virulence of many major bacterial pathogens. Proteins are exported through a genetically defined export gate complex consisting of three proteins.
Steven Johnson +4 more
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Type III secretion systems: the bacterial flagellum and the injectisome. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2015 The flagellum and the injectisome are two of the most complex and fascinating bacterial nanomachines. At their core, they share a type III secretion system (T3SS), a transmembrane export complex that forms the extracellular appendages, the flagellar filament and the injectisome needle. Recent advances, combining structural biology,
Diepold A, Armitage JP.
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Virulence-associated type III secretion systems in Gram-negative bacteria. [PDF]
Microbiology (Reading), 2023 Pais SV, Kim E, Wagner S.
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Virulence-Associated Genomic Architecture of Canine Otitis Externa-Derived Pseudomonas aeruginosa Isolates from Hungary [PDF]
Veterinary SciencesBackground: Canine otitis externa is a clinically relevant niche where Pseudomonas aeruginosa may persist under inflammatory, antimicrobial, and biofilm-favoring conditions.
Mercédesz Adrienn Veres +7 more
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Bacterial type III secretion systems: a complex device for the delivery of bacterial effector proteins into eukaryotic host cells. [PDF]
FEMS Microbiol Lett, 2018 Wagner S +5 more
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Recruitment of heterologous substrates by bacterial secretion systems for transkingdom translocation
Frontiers in Cellular and Infection Microbiology, 2023 Bacterial secretion systems mediate the selective exchange of macromolecules between bacteria and their environment, playing a pivotal role in processes such as horizontal gene transfer or virulence.
Dolores L. Guzmán-Herrador +2 more
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Acta Biochimica et Biophysica Sinica, 2022 Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic airway infection in bronchiectasis patients and is closely associated with poor prognosis.
Liu Yanan +7 more
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