Results 51 to 60 of about 18,345,299 (284)
Microbial Cell Factories, 2022 Background Bacterial type III secretion systems (T3SSs) assemble a multiprotein complex termed the injectisome, which acts as a molecular syringe for translocation of specific effector proteins into the cytoplasm of host cells.
Beatriz Álvarez +3 more
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mBio, 2018 Numerous Gram-negative bacterial pathogens utilize type III secretion systems (T3SSs) to inject tens of effector proteins directly into the cytosol of host cells.
Nadja Heinz Ernst +3 more
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Direct interaction of a chaperone-bound type III secretion substrate with the export gate
Nature Communications, 2022 Recruitment of substrates to virulent bacterial type III secretion systems remains enigmatic. Here, a crystal structure reveals two binding sites between a secretion substrate in complex with its chaperone and the cytosolic domain of the export gate.
Dominic Gilzer +2 more
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The type III secretion system effector network hypothesis
Trends in Microbiology, 2022 Type III secretion system (T3SS) effectors are key virulence factors that underpin the infection strategy of many clinically important Gram-negative pathogens, including Salmonella enterica, Shigella spp., enteropathogenic and enterohemorrhagic Escherichia coli and their murine equivalent, Citrobacter rodentium.
Julia Sanchez-Garrido +3 more
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Small-Molecule Inhibitors of the Type III Secretion System [PDF]
Molecules, 2015 Drug-resistant pathogens have presented increasing challenges to the discovery and development of new antibacterial agents. The type III secretion system (T3SS), existing in bacterial chromosomes or plasmids, is one of the most complicated protein secretion systems.
Lingling Gu +4 more
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Yersinia type III secretion : send in the effectors [PDF]
, 2002 Pathogenic Yersinia spp (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) have evolved an exquisite method for delivering powerful effectors into cells of the host immune system where they inhibit signaling cascades and block ...
Cornelis, Guy R +3 more
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Nature Communications, 2021 Virulent type III secretion systems (T3SSs) or injectisomes enable pathogenic bacteria to inject effector proteins directly into the host cell cytoplasm.
Sean Miletic +7 more
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VscF in T3SS1 Helps to Translocate VPA0226 in Vibrio parahaemolyticus
Frontiers in Cellular and Infection Microbiology, 2021 In Vibrio parahaemolyticus, type III secretion system 1 (T3SS1) is a major virulence factor that delivers effectors into the host eukaryotic cytoplasm; however, studies on its infection mechanism are currently limited.
Lele Lian +7 more
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Type III secretion systems and the evolution of mutualistic endosymbiosis [PDF]
Proceedings of the National Academy of Sciences, 2002 The view that parasites can develop cooperative symbiotic relationships with their hosts is both appealing and widely held; however, there is no molecular genetic evidence of such a transition. Here we demonstrate that a mutualistic bacterial endosymbiont of grain weevils maintains and expresses inv
Colin, Dale +4 more
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Accurate prediction of secreted substrates and identification of a conserved putative secretion signal for type III secretion systems. [PDF]
PLoS Pathogens, 2009 The type III secretion system is an essential component for virulence in many Gram-negative bacteria. Though components of the secretion system apparatus are conserved, its substrates--effector proteins--are not.
Ram Samudrala +2 more
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