Results 61 to 70 of about 18,345,299 (284)

Assembly and arrangement of the type three secretion system of "yersinia enterocolitica" [PDF]

, 2014
The type three secretion system (T3SS) is a bacterial weapon found in many Gram-negative bacteria. It consists out of a needle like structure called injectisome, which enables bacteria to inject effector proteins into eukaryotic cells. The injectisome is
Amstutz, Marlise
core   +1 more source

Control of membrane barrier during bacterial type-III protein secretion

Nature Communications, 2021
Type-III secretion systems (T3SSs) are capable of translocating proteins with high speed while maintaining the membrane barrier for small molecules. Here, a structure-function analysis of the T3SS pore complex elucidates the precise mechanisms enabling ...
Svenja Hüsing, Manuel Halte, Ulf van Look, Alina Guse, Eric J. C. Gálvez, Emmanuelle Charpentier, David F. Blair, Marc Erhardt, Thibaud T. Renault   +8 more
doaj   +1 more source

Type III Secretion: More Systems Than You Think

Physiology, 2005
The type III secretion (T3S) pathway allows bacteria to inject effector proteins into the cytosol of target animal or plant cells. T3S systems evolved into seven families that were distributed among Gram-negative bacteria by horizontal gene transfer. There are probably a few hundred effectors interfering with control and signaling in eukaryotic cells ...
Troisfontaines, P., Cornelis, G. R.
openaire   +5 more sources

Atomic model of the type III secretion system needle [PDF]

Nature, 2012
Pathogenic bacteria using a type III secretion system (T3SS) to manipulate host cells cause many different infections including Shigella dysentery, typhoid fever, enterohaemorrhagic colitis and bubonic plague. An essential part of the T3SS is a hollow needle-like protein filament through which effector proteins are injected into eukaryotic host cells ...
Loquet, Antoine, Sgourakis, Nikolaos, Gupta, Rashmi, Giller, Karin, Riedel, Dietmar, Goosmann, Christian, Griesinger, Christian, Kolbe, Michael, Baker, David, Becker, Stefan, Lange, Adam   +10 more
openaire   +7 more sources

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Characterisation of the effects of salicylidene acylhydrazide compounds on type three secretion in Escherichia coli O157:H7 [PDF]

, 2009
Recent work has highlighted a number of compounds that target bacterial virulence by affecting gene regulation. In this work, we show that small-molecule inhibitors affect the expression of the type III secretion system (T3SS) of <i>Escherichia ...
Layton, Abigail, Stevens, M. P., Tree, J.J., Stevens, Mark P, Tree, J. J., Roe, A. J., McInally, C., Roe, Andrew J, Tree, Jai J, Wang, Dai, Elofsson, M., Houghton, I., Mahajan, A., Stevens, M.P., Gally, D. L., Roe, A.J., Wang, D., Gally, D.L., Layton, A., Elofsson, Mikael,, McInally, Carol, Houghton, Irene, Mahajan, Arvind, Gally, David L   +23 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

CagI is an essential component of the Helicobacter pylori Cag type IV secretion system and forms a complex with CagL. [PDF]

, 2012
Helicobacter pylori, the causative agent of type B gastritis, peptic ulcers, gastric adenocarcinoma and MALT lymphoma, uses the Cag type IV secretion system to induce a strong proinflammatory response in the gastric mucosa and to inject its effector ...
Haas, Rainer, Rainer Haas, Weiss Evelyn, Breithaupt, Ute, Fischer Wolfgang, Ute Breithaupt, Jiménez Soto Luisa F., Pham, Kieu Thuy, Jiménez Soto, Luisa F., Haas Rainer, Weiss, Evelyn, Kieu Thuy Pham, Luisa F Jiménez Soto, Pham Kieu Thuy, Wolfgang Fischer, Evelyn Weiss, Breithaupt Ute, Fischer, Wolfgang   +17 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Established microbial colonies can survive type VI secretion assault [PDF]

, 2015
Type VI secretion (T6S) is a cell-to-cell injection system that can be used as a microbial weapon. T6S kills vulnerable cells, and is present in close to 25% of sequenced Gram-negative bacteria.
Ned S Wingreen, Marek Basler (173162), Basler, Marek, Ringel, Peter, David Bruce Borenstein, Peter Ringel (816293), Borenstein, David Bruce, Peter Ringel, Wingreen, Ned S., Wingreen, Ned, Marek Basler, David Bruce Borenstein (413437), Ned S. Wingreen (10926)   +12 more
core   +2 more sources