Type three secretion system-mediated escape of Burkholderia pseudomallei into the host cytosol is critical for the activation of NFκB. [PDF]
, 2014 BackgroundBurkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease endemic in Southeast Asia and Northern Australia.
Chen, Isabelle Gek Joo +9 more
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BMC Microbiology, 2011 Background Type III secretion systems (T3SS) of bacterial pathogens coordinate effector protein injection into eukaryotic cells. The YscU/FlhB group of proteins comprises members associated with T3SS which undergo a specific auto-cleavage event at a ...
He Xiang +2 more
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Crystal structure of Legionella DotD: insights into the relationship between type IVB and type II/III secretion systems. [PDF]
PLoS Pathogens, 2010 The Dot/Icm type IVB secretion system (T4BSS) is a pivotal determinant of Legionella pneumophila pathogenesis. L. pneumophila translocate more than 100 effector proteins into host cytoplasm using Dot/Icm T4BSS, modulating host cellular functions to ...
Noboru Nakano +4 more
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The Yersinia enterocolitica Ysa type III secretion system is expressed during infections both in vitro and in vivo. [PDF]
, 2013 Yersinia enterocolitica biovar 1B maintains two type III secretion systems (T3SS) that are involved in pathogenesis, the plasmid encoded Ysc T3SS and the chromosomally encoded Ysa T3SS.
Bent, Zachary W +2 more
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PLoS Computational Biology, 2006 From the analysis of 251 prokaryotic genomes stored in public databases, the 761,260 deduced proteins were used to reconstruct a complete set of bacterial proteic families. Using the new Overlap algorithm, we have partitioned the Protein Homology Network
Duccio Medini +2 more
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In-Vivo Expression Profiling of Pseudomonas aeruginosa Infections Reveals Niche-Specific and Strain-Independent Transcriptional Programs [PDF]
, 2011 Pseudomonas aeruginosa is a threatening, opportunistic pathogen causing disease in immunocompromised individuals. The hallmark of P. aeruginosa virulence is its multi-factorial and combinatorial nature.
Bielecki, Piotr +9 more
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Functional regulation and cross-talk of type III and type VI secretion systems in Salmonella
VirulenceIn Salmonella, the type III and type VI secretion systems (T3SS and T6SS) play critical roles in pathogenicity. The bacterium harbors two distinct T3SSs: T3SS-1, encoded by SPI-1, promotes host cell invasion, whereas T3SS-2 (located within SPI-2 ...
Xingyi Li +7 more
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Frontiers in Microbiology, 2019 Virulent Aeromonas hydrophila causes severe motile Aeromonas septicemia in warmwater fishes. In recent years, channel catfish farming in the U.S.A. and carp farming in China have been affected by virulent A.
Hasan C. Tekedar +5 more
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Caspase-11 activation in response to bacterial secretion systems that access the host cytosol. [PDF]
PLoS Pathogens, 2013 Inflammasome activation is important for antimicrobial defense because it induces cell death and regulates the secretion of IL-1 family cytokines, which play a critical role in inflammatory responses.
Cierra N Casson +10 more
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Mycobacterium tuberculosis type VII secretion system effectors differentially impact the ESCRT endomembrane damage response [PDF]
, 2018 Mycobacterium tuberculosis causes tuberculosis, which kills more people than any other infection. M. tuberculosis grows in macrophages, cells that specialize in engulfing and degrading microorganisms.
Hanson, Phyllis I +7 more
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