Beyond movement: the dynamic roles of Type IV pili in cyanobacterial life [PDF]
Journal of BacteriologyType IV pili are versatile prokaryotic cell appendages that are extremely widespread in the bacterial and archaeal domains of life. The structure, dynamics, and functions of type IV pili have been most intensively studied in several species of ...
Jonas Hammerl +4 more
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Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms [PDF]
Nature CommunicationsType IV pili (T4P) are prevalent, polymeric surface structures in pathogenic bacteria, making them ideal targets for effective vaccines. However, bacteria have evolved efficient strategies to evade type IV pili-directed antibody responses.
David Fernandez-Martinez +11 more
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Structural basis of Acinetobacter type IV pili targeting by an RNA virus [PDF]
Nature CommunicationsAcinetobacters pose a significant threat to human health, especially those with weakened immune systems. Type IV pili of acinetobacters play crucial roles in virulence and antibiotic resistance.
Ran Meng +12 more
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Subcellular localization of type IV pili regulates bacterial multicellular development [PDF]
Nature Communications, 2022 Bacteria can form organized multicellular communities through regulation of cell growth, motility, shape and differentiation. Here, Ellison et al. show that bacterial multicellular development can also be driven by specific patterns of localization of ...
Courtney K. Ellison +6 more
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Type IV Pili of Streptococcus sanguinis Contribute to Pathogenesis in Experimental Infective Endocarditis [PDF]
Microbiology Spectrum, 2021 Streptococcus sanguinis is a common cause of infective endocarditis (IE). Efforts by research groups are aimed at identifying and characterizing virulence factors that contribute to the ability of this organism to cause IE.
Anthony M. Martini +3 more
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Microbial nanowires: type IV pili or cytochrome filaments? [PDF]
Trends Microbiol, 2023 A dynamic field of study has emerged involving long-range electron transport by extracellular filaments in anaerobic bacteria, with Geobacter sulfurreducens being used as a model system.
Wang F +4 more
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Tad and toxin-coregulated pilus structures reveal unexpected diversity in bacterial type IV pili. [PDF]
Proc Natl Acad Sci U S A, 2023 Significance Type IV pili (T4P) are widely found in prokaryotes (bacteria and archaea). They are directly involved in a large range of functions, including surface sensing, biofilm formation, twitching motility, and uptake of DNA.
Sonani RR +6 more
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Type IV pili trigger episymbiotic association of Saccharibacteria with its bacterial host. [PDF]
Proc Natl Acad Sci U S A, 2022 Significance Candidate phyla radiation (CPR) is a large clade of bacterial lineages that account for approximately one quarter of microbial diversity.
Xie B +8 more
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Pseudomonas aeruginosa senses exopolysaccharide trails using type IV pili and adhesins during biofilm formation. [PDF]
Nat MicrobiolDuring early stages of biofilm formation, Pseudomonas aeruginosa (Pa) PAO1 can sense exopolysaccharide (EPS) trails of Psl deposited on a surface by previous Pa cells to detect trajectories of other cells and to orchestrate motility.
Schmidt WC +12 more
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Autoinducer-2 promotes adherence of Aeromonas veronii through facilitating the expression of MSHA type IV pili genes mediated by c-di-GMP. [PDF]
Appl Environ Microbiol, 2023 Aeromonas veronii. a ubiquitous of zoonotic disease pathogen, depends on adhesion as the crucial way to colonize the gastrointestinal tract of humans and animals, which further causes severe gastrointestinal diseases and parenteral infections.
Li Y +9 more
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