Results 31 to 40 of about 40,764 (218)
Type IV Pili as a Therapeutic Target [PDF]
Trends in Microbiology, 2019 In the age of antibiotic resistance, strategies targeting virulence traits of bacteria are the focus of intense study. Two such studies came out independently a week apart showing that bacterial type IV pili are a promising therapeutic target.
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2022 The genome of Mycobacterium tuberculosis (Mtb) harbors the genetic machinery for assembly of the Fimbrial low-molecular-weight protein (Flp) type IV pilus. Presumably, the Flp pilus is essential for pathogenesis.
Christopher J. Alteri +13 more
doaj +1 more source
Architecture of the type IVa pilus machine [PDF]
, 2016 Many bacteria, including important pathogens, move by projecting grappling-hook–like extensions called type IV pili from their cell bodies. After these pili attach to other cells or objects in their environment, the bacteria retract the pili to pull ...
Chang, Yi-Wei +5 more
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DNA Uptake by Type IV Filaments
Frontiers in Molecular Biosciences, 2019 Bacterial uptake of DNA through type IV filaments is an essential component of natural competence in numerous gram-positive and gram-negative species.
Kurt H. Piepenbrink +3 more
doaj +1 more source
Structure and function of minor pilins of type IV pili. [PDF]
Med Microbiol Immunol, 2020 AbstractType IV pili are versatile and highly flexible fibers formed on the surface of many Gram-negative and Gram-positive bacteria. Virulence and infection rate of several pathogenic bacteria, such as Neisseria meningitidis and Pseudomonas aeruginosa, are strongly dependent on the presence of pili as they facilitate the adhesion of the bacteria to ...
Jacobsen T +4 more
europepmc +5 more sources
Ralstonia solanacearum Needs Flp Pili for Virulence on Potato
Molecular Plant-Microbe Interactions, 2012 Type IV pili are virulence factors in various bacteria. Several subclasses of type IV pili have been described according to the characteristics of the structural prepilin subunit.
Charles K. Wairuri +3 more
doaj +1 more source
Manganese acquisition is facilitated by PilA in the cyanobacterium Synechocystis sp. PCC 6803. [PDF]
PLoS ONE, 2017 Manganese is an essential element required by cyanobacteria, as it is an essential part of the oxygen-evolving center of photosystem II. In the presence of atmospheric oxygen, manganese is present as manganese oxides, which have low solubility and ...
Jacob J Lamb, Martin F Hohmann-Marriott
doaj +1 more source
Functional plasticity in the type IV secretion system of Helicobacter pylori. [PDF]
, 2012 Helicobacter pylori causes clinical disease primarily in those individuals infected with a strain that carries the cytotoxin associated gene pathogenicity island (cagPAI).
Barrozo, Roberto M +10 more
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Characterization of four type IV pilin homologues in Stigmatella aurantiaca DSM17044 by heterologous expression in Myxococcus xanthus. [PDF]
PLoS ONE, 2013 As prokaryotic models for multicellular development, Stigmatella aurantiaca and Myxococcus xanthus share many similarities in terms of social behaviors, such as gliding motility.
Zaigao Tan +7 more
doaj +1 more source
Type IV pili interactions promote intercellular association and moderate swarming of Pseudomonas aeruginosa [PDF]
, 2014 Pseudomonas aeruginosa is a ubiquitous bacterium that survives in many environments, including as an acute and chronic pathogen in humans. Substantial evidence shows that P.
Alber, Mark S. +7 more
core +2 more sources