OxyR contributes to virulence of Acidovorax citrulli by regulating anti-oxidative stress and expression of flagellin FliC and type IV pili PilA. [PDF]
Front Microbiol, 2022 In many bacteria, OxyR acts as a transcriptional regulator that facilitates infection via degrading hydrogen peroxide (H2O2) generated by the host defense response.
Wang J +7 more
europepmc +2 more sources
Global Regulatory Pathways Converge To Control Expression of Pseudomonas aeruginosa Type IV Pili. [PDF]
mBio, 2022 Pseudomonas aeruginosa is an opportunistic pathogen responsible for a wide range of infections. An extensive repertoire of virulence factors aid in P. aeruginosa pathogenesis. ABSTRACT The opportunistic pathogen Pseudomonas aeruginosa relies upon type IV
Coggan KA +8 more
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Type IV pili - A numbers game [PDF]
The EMBO Journal, 2014 Type IV pili are long polymers located on the surface of a wide variety of bacterial cells, including the pathogen Neisseria meningitidis. They are responsible for a diverse range of functions, including adhesion, motility and natural transformation.
Derrick, Jeremy P. +3 more
core +5 more sources
Effectiveness of Pseudomonas aeruginosa type VI secretion system relies on toxin potency and type IV pili-dependent interaction. [PDF]
PLoS Pathog, 2023 The type VI secretion system (T6SS) is an antibacterial weapon that is used by numerous Gram-negative bacteria to gain competitive advantage by injecting toxins into adjacent prey cells.
Rudzite M +3 more
europepmc +2 more sources
DNA Uptake by Type IV Filaments [PDF]
Frontiers in Molecular Biosciences, 2019 Bacterial uptake of DNA through type IV filaments is an essential component of natural competence in numerous gram-positive and gram-negative species.
Kurt H. Piepenbrink +3 more
doaj +4 more sources
Motor-independent retraction of type IV pili is governed by an inherent property of the pilus filament. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Extracellular pilus filaments are critical for the virulence and persistence of many bacterial pathogens. A crucial property of these filaments is their ability to dynamically extend and retract from the bacterial surface.
Chlebek JL, Denise R, Craig L, Dalia AB.
europepmc +2 more sources
Characterization of Pseudomonas aeruginosa Bacteriophage L5 Which Requires Type IV Pili for Infection. [PDF]
Front Microbiol, 2022 Pseudomonas aeruginosa is a common opportunistic human pathogen. With the emergence of multidrug-resistant (MDR) clinical infection of P. aeruginosa, phage therapy has received renewed attention in treating P. aeruginosa infections.
Yang L +7 more
europepmc +2 more sources
Structural insights into the Thermus thermophilus type IV pilus machinery assembling two distinct pili [PDF]
Communications BiologyType IV pili are long, filamentous structures that extend from bacterial cell surfaces, enabling cells to respond to changing environments and facilitating genome plasticity.
Alexander Neuhaus +9 more
doaj +7 more sources
The involvement of type IV pili and the phytochrome CphA in gliding motility, lateral motility and photophobotaxis of the cyanobacterium Phormidium lacuna. [PDF]
PLoS One, 2022 Phormidium lacuna is a naturally competent, filamentous cyanobacterium that belongs to the order Oscillatoriales. The filaments are motile on agar and other surfaces and display rapid lateral movements in liquid culture.
Lamparter T +10 more
europepmc +2 more sources
Role of type IV pili in predation by Bdellovibrio bacteriovorus. [PDF]
PLoS ONE, 2014 Bdellovibrio bacteriovorus, as an obligate predator of Gram-negative bacteria, requires contact with the surface of a prey cell in order to initiate the life cycle.
Ryan M Chanyi, Susan F Koval
doaj +5 more sources