Results 91 to 100 of about 40,764 (218)

Pseudomonas aeruginosa pilin activates the inflammasome [PDF]

, 2011
IL-1 beta is produced from inactive pro-IL-1 beta by activation of caspase-1 brought about by a multi-subunit protein platform called the inflammasome. Many bacteria can trigger inflammasome activity through flagellin activation of the host protein NLRC4.
Agostini, Andersen-Nissen, Arora, Auron, Bergsbaken, Bird, Bitter, Case, Choi, Cornelis, Craig, Dinarello, Evans, Franchi, Franchi, Franchi, Hahn, Hazes, Hsu, Johnson, Kanneganti, Kus, Lightfield, Lindestam Arlehamn, Liu, Marathe, Mariathasan, Mariathasan, Martinon, Martinon, Mattick, Miao, Miao, Miao, Murray, Muruve, Neyt, O'Neill, Perkins, Pier, Proft, Sato, Sato, Sawa, Schroeder, Semmler, Smedley, Sutterwala, Sutterwala, Thornberry, Ting, Vallis, von Götz, Ye, Yu   +54 more
core   +1 more source

Type IV pili: e pluribus unum? [PDF]

Molecular Microbiology, 2008
SummaryThe widespread role of pili as colonization factors in pathogens has long been recognized in Gram‐negative bacteria and more recently in Gram‐positive bacteria, making the study of these hair‐like filaments a perennial hot topic for research. No other pili are found in as many or as diverse bacteria as type IV pili.
openaire   +3 more sources

Nanoscale Adhesion Forces of Pseudomonas aeruginosa Type IV Pili [PDF]

ACS Nano, 2014
A variety of bacterial pathogens use nanoscale protein fibers called type IV pili to mediate cell adhesion, a primary step leading to infection. Currently, how these nanofibers respond to mechanical stimuli and how this response is used to control adhesion is poorly understood.
Beaussart, Audrey, Baker, Amy E., Kuchma, Sherry L., El-Kirat-Chatel, Sofiane, O’Toole, George A., Dufrêne, Yves F.   +5 more
openaire   +2 more sources

Hair Degradation Patterns in Aquatic and Soil Environments

Archaeometry, EarlyView.
ABSTRACT Hair is a biological material that can provide information in archaeology and forensics. Previous studies have mainly examined changes occurring post‐mortem. In this study, we focused on hair pulled out ante‐mortem. The aim of the study was to identify patterns in the degradation of hair in water and soil.
Katarzyna Palacz‐Ziółek, Monika Krzyżanowska, Rafał Ogórek, Marcin Kadej   +3 more
wiley   +1 more source

Structure of the Neisseria meningitidis Type IV pilus

Nature Communications, 2016
Type IV pili are present on a wide range of bacterial pathogens and mediate diverse functions. Here the authors report a high resolution crystal structure of the pilin subunit PilE, and a cryoEM reconstruction of the Type IV pilus filament from N ...
Subramania Kolappan, Mathieu Coureuil, Xiong Yu, Xavier Nassif, Edward H. Egelman, Lisa Craig   +5 more
doaj   +1 more source

Melioidosis in companion animals: Analysis of 45 Australian cases (24 dogs; 21 cats) from 1997 to 2025 and a brief review of the animal and human literature

Australian Veterinary Journal, EarlyView.
Objective To report 45 cases of melioidosis in dogs and cats from northern Australia and analyse trends in epidemiology, clinical presentation, pathogenesis and response to treatment over a 27‐year period. Design Retrospective and prospective analysis of clinical records.
K Lee, C Shilton, S Benedict, M Krockenberger, M Mayo, BJ Currie, R Malik   +6 more
wiley   +1 more source

Attenuation of Type IV pili activity by natural products

Journal of Biomolecular Structure and Dynamics
The virulence factor Type IV pili (T4P) are surface appendages used by the opportunistic pathogen Pseudomonas aeruginosa for twitching motility and adhesion in the environment and during infection. Additionally, the use of these appendages by P. aeruginosa for biofilm formation increases its virulence and drug resistance.
Yalkut, Kerem, Ben Ali Hassine, Soumaya, Basaran, Esra, Kula, Ceyda, Ozcan, Aslıhan, Avci, Fatma Gizem, Keskin, Ozlem, Sariyar Akbulut, Berna, Ozbek, Pemra   +8 more
openaire   +3 more sources

Chasing the perfida Albione: Anglo‐Italian productivity gap in the late 1930s

The Economic History Review, EarlyView.
Abstract This paper presents new estimates of Anglo‐Italian labour productivity levels in manufacturing in the late 1930s, derived using the standard single‐deflation approach. The findings confirm a substantial productivity gap between Italy and the United Kingdom at the aggregate level, alongside pronounced intersectoral heterogeneity.
Tancredi Salamone
wiley   +1 more source

Adhesion of Neisseria meningitidis to dermal vessels leads to local vascular damage and purpura in a humanized mouse model.

PLoS Pathogens, 2013
Septic shock caused by Neisseria meningitidis is typically rapidly evolving and often fatal despite antibiotic therapy. Further understanding of the mechanisms underlying the disease is necessary to reduce fatality rates.
Keira Melican, Paula Michea Veloso, Tiffany Martin, Patrick Bruneval, Guillaume Duménil   +4 more
doaj   +1 more source

A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections [PDF]

, 2016
Bacteriophage therapy is currently resurging as a potential complement/alternative to antibiotic treatment. However, preclinical evaluation lacks streamlined approaches.
Arabski, Michal, Briers, Yves, Danis-Wlodarczyk, Katarzyna, Drabik, Marcin, Drulis-Kawa, Zuzanna, Harvey, Brian J, Higgins, Gerard, Jang, Ho Bing, Lavigne, Rob, Noben, Jean-Paul, Olszak, Tomasz, Tyrrell, Jean, Vandenheuvel, Dieter, Wasik, Slawomir   +13 more
core   +2 more sources