Results 91 to 100 of about 9,001,251 (226)

RNA-seq analysis reveals a crucial role for thioredoxin in type IV pili production.

, 2019
(A) Heatmap of differentially regulated genes associated with the type IV pili (T4P). (B) Schematic of the Gram-negative T4P with red boxes indicating the genes downregulated in the mutant. (C) qRT-PCR of select T4P genes.
Bernard P. Arulanandam (225852), Jieh-Juen Yu (225801), Holly C. May (6905516), Andrew P. Cap (577204), James P. Chambers (225842), M. Neal Guentzel (225820), Yufeng Wang (274657), Hao Zhang (15339)   +7 more
core   +1 more source

Timing Matters: A Meta‐Analysis of BREAST‐Q Administration in Tissue‐Expander and Implant‐Based Breast Reconstruction

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background BREAST‐Q is the most widely used patient‐reported outcome measure following breast reconstruction, yet no consensus exists on optimal timing or duration of administration. We analyzed BREAST‐Q follow‐up after implant‐based reconstruction, comparing direct‐to‐implant (DTI) and two‐stage tissue expander (TE), to determine how outcomes
Emanuella M. Brito, Isabel Bernal, Sean K. Park, Julia L. Armstrong, Natalia Correa, Anthony Pasarin, Anastasia Tousimis, Graham S. Schwarz, Martin I. Newman   +8 more
wiley   +1 more source

Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium.

, 2009
International audienceType IV pili mediate the initial interaction of many bacterial pathogens with their host cells. In Neisseria meningitidis, the causative agent of cerebrospinal meningitis, type IV pili-mediated adhesion to brain endothelial cells is
Romero, Ignacio, A., Duménil, Guillaume, Mathieu, Coureuil, Coureuil, Mathieu, Weksler, Babette B., Mikaty, Guillain, Bourdoulous, Sandrine, Couraud, Pierre Olivier, Couraud, Pierre-Olivier, Nassif, Xavier, Miller, Florence, Mège, René-Marc, Weksler, Babette, B., Bernard, Christine, Romero, Ignacio A., Lécuyer, Hervé   +15 more
core   +1 more source

Structural Diversity in the Type IV Pili of Multidrug-resistant Acinetobacter [PDF]

Journal of Biological Chemistry, 2016
Acinetobacter baumannii is a Gram-negative coccobacillus found primarily in hospital settings that has recently emerged as a source of hospital-acquired infections. A. baumannii expresses a variety of virulence factors, including type IV pili, bacterial extracellular appendages often essential for attachment to host cells.
Piepenbrink, Kurt H, Lillehoj, Erik, Harding, Christian M, Labonte, Jason W, Zuo, Xiaotong, Rapp, Chelsea A, Munson, Robert S, Jr, Goldblum, Simeon E, Feldman, Mario F, Gray, Jeffrey J, Sundberg, Eric J   +10 more
openaire   +3 more sources

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Adhesion pilus retraction powers twitching motility in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius

Nature Communications
Type IV pili are filamentous appendages found in most bacteria and archaea, where they can support functions such as surface adhesion, DNA uptake, aggregation, and motility. In most bacteria, PilT-family ATPases disassemble adhesion pili, causing them to
Arthur Charles-Orszag, Marleen van Wolferen, Samuel J. Lord, Sonja-Verena Albers, R. Dyche Mullins   +4 more
doaj   +1 more source

Steered molecular dynamics simulations of a type IV pilus probe initial stages of a force-induced conformational transition. [PDF]

PLoS Computational Biology, 2013
Type IV pili are long, protein filaments built from a repeating subunit that protrudes from the surface of a wide variety of infectious bacteria. They are implicated in a vast array of functions, ranging from bacterial motility to microcolony formation ...
Joseph L Baker, Nicolas Biais, Florence Tama   +2 more
doaj   +1 more source

Fresh Extension of Vibrio cholerae Competence Type IV Pili Predisposes Them for Motor-Independent Retraction

bioRxiv, 2021
Extracellular pilus fibers are critical to the virulence and persistence of many pathogenic bacteria. A crucial function for most pili is the dynamic ability to extend and retract from the cell surface.
J. Chlebek, Triana N. Dalia, N. Biais, A. B. Dalia   +3 more
semanticscholar   +1 more source

Biosurfactant production by Pseudomonas aeruginosa isolated from mining waste: From genomic analysis to development of a polymeric composite for removal of hexavalent chromium

Polymer International, EarlyView.
Biosurfactant was produced by Pseudomonas aeruginosa using andiroba waste from Amazonia. A biosurfactant–alginate composite (Alg/BioS) was successfully synthesized via ionotropic gelation, and achieved up to 70% Cr6+ removal from water. Abstract Environmental contamination by heavy metals represents a significant challenge due to their persistence in ...
Paulo Diniz Austriaco, Emilly Cruz da Silva, Glenda Sores Gomes, Joane Almeida Alves, Amanda Vidal, Leandro Argolo, Rafaela Ribeiro, Luciana Souza, José Augusto Pires Bitencourt, Leonardo Brasil Felipe, Leonie Asfora Sarubbo, Sidnei Cerqueira dos Santos   +11 more
wiley   +1 more source

Genomic, Transcriptomic, and Phenotypic Analyses of Neisseria meningitidis Isolates from Disease Patients and Their Household Contacts

mSystems, 2017
Neisseria meningitidis (meningococcus) can cause meningococcal disease, a rapidly progressing and often fatal disease that can occur in previously healthy children.
Xiaoyun Ren, David A. Eccles, Gabrielle A. Greig, Jane Clapham, Nicole E. Wheeler, Stinus Lindgreen, Paul P. Gardner, Joanna K. MacKichan   +7 more
doaj   +1 more source