Results 111 to 120 of about 40,535 (204)

A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections [PDF]

, 2016
Bacteriophage therapy is currently resurging as a potential complement/alternative to antibiotic treatment. However, preclinical evaluation lacks streamlined approaches.
Arabski, Michal, Briers, Yves, Danis-Wlodarczyk, Katarzyna, Drabik, Marcin, Drulis-Kawa, Zuzanna, Harvey, Brian J, Higgins, Gerard, Jang, Ho Bing, Lavigne, Rob, Noben, Jean-Paul, Olszak, Tomasz, Tyrrell, Jean, Vandenheuvel, Dieter, Wasik, Slawomir   +13 more
core   +2 more sources

Attenuation of Type IV pili activity by natural products

Journal of Biomolecular Structure and Dynamics
The virulence factor Type IV pili (T4P) are surface appendages used by the opportunistic pathogen Pseudomonas aeruginosa for twitching motility and adhesion in the environment and during infection. Additionally, the use of these appendages by P. aeruginosa for biofilm formation increases its virulence and drug resistance.
Yalkut, Kerem, Ben Ali Hassine, Soumaya, Basaran, Esra, Kula, Ceyda, Ozcan, Aslıhan, Avci, Fatma Gizem, Keskin, Ozlem, Sariyar Akbulut, Berna, Ozbek, Pemra   +8 more
openaire   +3 more sources

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

The Effect of Two Weight Reduction Maintenance Strategies for Moderately/Mildly Retarded Adults [PDF]

, 1986
Thirteen retarded adult subjects were first exposed to a 12-week behavior therapy weight reduction program followed by a ten-month weekly weigh-in. Then the subjects were randomly assigned to an experimental maintenance booster session group (n=7) or a ...
Fox, Robert, Matson, Johnny, Rotatori, Anthony F., Sexton, David, Wade, Patricia, Zinkgraf, Stephen   +5 more
core   +1 more source

HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma [PDF]

, 2016
Indexación: Web of ScienceBackground: Class I histone deacetylases (HDACs) have been reported to be overexpressed in clear cell renal cell carcinoma (ccRCC), whereas the expression of class II HDACs is unknown.
Attwood, Kris, Chintala, Sreenivasulu, Ciamporcero, Eric, Conroy, Dylan, Das, Gokul, Ellis, Leigh, Huang, Ray, Ku, ShengYu, Miles, Kiersten Marie, Orillion, Ashley, Pili, Roberto, Ramakrishnan, Swathi, Shen, Li, Sotomayor, Paula, Swetzig, Wendy   +14 more
core   +2 more sources

ssRNA bacteriophage metagenomes reveal a diverse set of novel protein families

Protein Science, Volume 35, Issue 5, May 2026.
Abstract The bacteriophages with single‐stranded RNA (ssRNA) genomes (class Leviviricetes) are among the simplest known viruses that encode only three core proteins: a receptor‐binding protein, a capsid protein, and an RNA‐dependent RNA polymerase. The number of isolated ssRNA phages has remained very low, but the accumulating RNA metagenome data have ...
Jānis Rūmnieks, Ieva Baltā, Mihails Šišovs, Kaspars Tārs   +3 more
wiley   +1 more source

Heterogeneity in Surface Sensing Suggests a Division of Labor in Pseudomonas aeruginosa Populations [PDF]

, 2019
The second messenger signaling molecule cyclic diguanylate monophosphate (c-di-GMP) drives the transition between planktonic and biofilm growth in many bacterial species.
Armbuster, Catherine R., de Anda, Jaime, Harwood, Caroline S., Hoffman, Lucas R., Jin, Fan, Lee, Calvin K., Murakami, Keiji, Parker-Gilham, Jessica, Parsek, Matthew R., Tseng, Boo Shan, Wong, Gerard CL, Xia, Aiguo, Zhao, Kun   +12 more
core   +2 more sources

The Ti Plasmid‐Encoded VirJ Functions as a Lysyl‐Phosphatidylglycerol Hydrolase in Agrobacterium tumefaciens

Molecular Microbiology, Volume 125, Issue 5, Page 426-441, May 2026.
We identify the long‐known virulence factor VirJ as a lysyl‐phosphatidylglycerol (L‐PG) hydrolase. Like the chromosomally encoded virulence factor AcvB, it prevents excessive accumulation of L‐PG in the membrane, thereby maintaining efficient T‐DNA transfer via the Type IV secretion system (T4SS) in Agrobacterium tumefaciens.
Britta Lotz, Lina Brodskaia, Christiane Fritz, Stefanie Hebecker, Maike K. Tauchert, Jennifer Breisch, Dieter Jahn, Franz Narberhaus, Jürgen Moser, Meriyem Aktas   +9 more
wiley   +1 more source

Type IV pili in Francisella – A virulence trait in an intracellular pathogen

Frontiers in Cellular and Infection Microbiology, 2011
Francisella tularensis is a highly virulent intracellular human pathogen that is capable of rapid proliferation in the infected host. Mutants affected in intracellular survival and growth are highly attenuated which highlights the importance of the ...
Emelie eNäslund Salomonsson, Anna-Lena eForslund, Åke eForsberg   +2 more
doaj   +1 more source

Chemo‐Enzymatic Route for Covalent Cellulose Fiber Dyeing

Chemistry – A European Journal, Volume 32, Issue 14, 15 April 2026.
This work presents a proof of concept for a chemo‐enzymatic approach to the covalent dyeing of cotton fibers. Laccase/TEMPO oxidation introduces aldehyde groups, enabling subsequent reductive amination with amino dyes. Excellent color homogeneity and wash fastness were demonstrated using acid red 33, highlighting the robustness of the approach and its ...
Awilda Maccow, Etienne Severac, Sandrine Morel, Claire Moulis, Guillaume Boissonnat, Magali Remaud‐Simeon, David Guieysse   +6 more
wiley   +1 more source