Type VI secretion system effectors: poisons with a purpose [PDF]
Nature Reviews Microbiology, 2014 The type VI secretion system (T6SS) mediates interactions between a broad range of Gram-negative bacterial species. Recent studies have led to a substantial increase in the number of characterized T6SS effector proteins and a more complete and nuanced view of the adaptive importance of the system.
Alistair B, Russell +2 more
openaire +4 more sources
P . aeruginosa type III and type VI secretion systems modulate early response gene expression in type II pneumocytes in vitro [PDF]
BMC Genomics, 2022 Background Lung airway epithelial cells are part of innate immunity and the frontline of defense against bacterial infections. During infection, airway epithelial cells secrete proinflammatory mediators that participate in the recruitment of immune cells.
Emel Sen-Kilic +3 more
doaj +2 more sources
Pseudomonas fluorescens F113 type VI secretion systems mediate bacterial killing and adaption to the rhizosphere microbiome [PDF]
Scientific Reports, 2021 The genome of Pseudomonas fluorescens F113, a model rhizobacterium and a plant growth-promoting agent, encodes three putative type VI secretion systems (T6SSs); F1-, F2- and F3-T6SS.
David Durán +7 more
doaj +2 more sources
A pangenomic atlas reveals eco-evolutionary dynamics that shape type VI secretion systems in plant-pathogenic Ralstonia [PDF]
mBioSoilborne Ralstonia solanacearum species complex (RSSC) pathogens disrupt microbial communities as they invade roots and fatally wilt plants. RSSC pathogens secrete antimicrobial toxins using a type VI secretion system (T6SS).
Nathalie Aoun +6 more
doaj +2 more sources
Divergent control of two type VI secretion systems by RpoN in Pseudomonas aeruginosa. [PDF]
PLoS ONE, 2013 Three Type VI Secretion System (T6SS) loci called H1- to H3-T6SS coexist in Pseudomonas aeruginosa. H1-T6SS targets prokaryotic cells whereas H2-T6SS mediates interactions with both eukaryotic and prokaryotic host cells.
Thibault G Sana +4 more
doaj +2 more sources
A DNase Type VI Secretion System Effector Requires Its MIX Domain for Secretion
Microbiology Spectrum, 2022 Gram-negative bacteria often employ the type VI secretion system (T6SS) to deliver diverse cocktails of antibacterial effectors into rival bacteria.
Chaya Mushka Fridman +4 more
doaj +3 more sources
Nature Communications, 2018 It is unclear how Rhs toxins lacking a PAAR motif are secreted by Type VI secretion systems. Here, the authors show for one of these proteins that the mechanism requires removal of an N-terminal fragment by auto-proteolysis, followed by interaction with ...
Nan Jiang +10 more
doaj +2 more sources
Mutations in Two Paraburkholderia phymatum Type VI Secretion Systems Cause Reduced Fitness in Interbacterial Competition [PDF]
Frontiers in Microbiology, 2017 Paraburkholderia phymatum is a highly effective microsymbiont of Mimosa spp. and has also been shown to nodulate papilionoid legumes. P. phymatum was found to be highly competitive both in a natural environment as well as under controlled test conditions
Samanta Bolzan de Campos +4 more
doaj +2 more sources
Francisella IglG protein and the DUF4280 proteins: PAAR-like proteins in non-canonical Type VI secretion systems? [PDF]
Microbial Cell, 2016 Type VI secretion systems (T6SS) are bacterial molecular machines translocating effector proteins into target cells. T6SS are widely present in Gram-negative bacteria where they predominantly act to kill neighboring bacteria.
Claire Lays, Thomas Henry
doaj +2 more sources
Type VI Secretion Systems and the Gut Microbiota. [PDF]
Microbiol Spectr, 2019 ABSTRACT The human colonic microbiota is a dense ecosystem comprised of numerous microbes, including bacteria, phage, fungi, archaea, and protozoa, that compete for nutrients and space. Studies are beginning to reveal the antagonistic mechanisms that gut bacteria use to compete with other members of this ecosystem. In the healthy
Coyne MJ, Comstock LE.
europepmc +4 more sources