Francisella IglG protein and the DUF4280 proteins: PAAR-like proteins in non-canonical Type VI secretion systems? [PDF]
Microbial Cell, 2016 Type VI secretion systems (T6SS) are bacterial molecular machines translocating effector proteins into target cells. T6SS are widely present in Gram-negative bacteria where they predominantly act to kill neighboring bacteria.
Claire Lays, Thomas Henry
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Type VI secretion system : secretion by a contractile nanomachine [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2015 The type VI secretion systems (T6SS) are present in about a quarter of all Gram-negative bacteria. Several key components of T6SS are evolutionarily related to components of contractile nanomachines such as phages and R-type pyocins. The T6SS assembly is
Basler, Marek
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Presence and absence of type VI secretion systems in bacteria [PDF]
Microbiology (Reading, England), 2022 The type VI secretion system (T6SS) is a molecular puncturing device that enables Gram-negative bacteria to kill competitors, manipulate host cells and take up nutrients. Who would want to miss such superpowers?
Unterweger, D. ; https://orcid.org/ +4 more
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Structural biology of type VI secretion systems. [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2012 International audienceType VI secretion systems (T6SSs) are transenvelope complexes specialized in the transport of proteins or domains directly into target cells.
Cambillau, Christian +2 more
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The type VI secretion system: a tubular story [PDF]
The EMBO Journal, 2009 The molecular mechanism by which proteins are secreted in gram-negative bacteria is supported by nanomachines called type I to type VI secretion systems (T1SS to T6SS).
Filloux, Alain, Alain Filloux
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High temperatures increase the virulence of Vibrio bacteria towards their coral host and competing bacteria via type VI secretion systems. [PDF]
PLoS BiologyThe bacterial pathogen Vibrio coralliilyticus induces severe coral diseases in warming oceans. A study in PLOS Biology reveals that high temperatures activate 2 type VI secretion systems in V.
Weiquan Wang, Kaihao Tang, Xiaoxue Wang
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The Roles of Two Type VI Secretion Systems in Cronobacter sakazakii ATCC 12868 [PDF]
Frontiers in Microbiology, 2018 The type VI secretion system (T6SS), which has been found in 25% of gram-negative bacteria, is a crucial virulence factor in several pathogens. Although T6SS gene loci have been discovered in Cronobacter species, one of the major opportunistic foodborne ...
Min Wang +17 more
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Structure and Activity of the Type VI Secretion System [PDF]
Microbiology Spectrum, 2019 International audienceThe type VI secretion system (T6SS) is a multiprotein machine that uses a spring-like mechanism to inject effectors into target cells.
Durand, Eric +5 more
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P . aeruginosa type III and type VI secretion systems modulate early response gene expression in type II pneumocytes in vitro [PDF]
BMC Genomics, 2022 Background Lung airway epithelial cells are part of innate immunity and the frontline of defense against bacterial infections. During infection, airway epithelial cells secrete proinflammatory mediators that participate in the recruitment of immune cells.
Emel Sen-Kilic +3 more
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A pangenomic atlas reveals eco-evolutionary dynamics that shape type VI secretion systems in plant-pathogenic Ralstonia [PDF]
mBioSoilborne Ralstonia solanacearum species complex (RSSC) pathogens disrupt microbial communities as they invade roots and fatally wilt plants. RSSC pathogens secrete antimicrobial toxins using a type VI secretion system (T6SS).
Nathalie Aoun +6 more
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