Results 61 to 70 of about 33,313 (146)

Mounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin

Nature Communications, 2021
Rearrangement hot spots (Rhs) proteins are bacterial polymorphic toxin systems. Here, the authors show that Rhs1 forms a complex with the Type VI secretion system (T6SS) spike protein VgrG and the EagR chaperone.
Dukas Jurėnas, Leonardo Talachia Rosa, Martial Rey, Julia Chamot-Rooke, Rémi Fronzes, Eric Cascales   +5 more
doaj   +1 more source

Crosstalk Between Type VI Secretion System and Mobile Genetic Elements [PDF]

Frontiers in Molecular Biosciences, 2019
Many bacterial processes require cell-cell contacts. Such are the cases of bacterial conjugation, one of the main horizontal gene transfer mechanisms that physically spreads DNA, and the type VI secretion systems (T6SSs), which deploy antibacterial activity.
Arancha Peñil-Celis, M. Pilar Garcillán-Barcia   +1 more
openaire   +4 more sources

Architecture and assembly of the Type VI secretion system

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2014
The Type VI secretion system (T6SS) delivers protein effectors to diverse cell types including prokaryotic and eukaryotic cells, therefore it participates in inter-bacterial competition and pathogenesis. The T6SS is constituted of an envelope-spanning complex anchoring a cytoplasmic tubular edifice.
Zoued, Abdelrahim, Brunet, Yannick R, Durand, Eric, Aschtgen, Marie-Stéphanie, Logger, Laureen, Douzi, Badreddine, Journet, Laure, Cambillau, Christian, Cascales, E.   +8 more
openaire   +4 more sources

Regulation of Type VI Secretion System during Burkholderia pseudomallei Infection [PDF]

Infection and Immunity, 2011
ABSTRACT Type III and type VI secretion systems (T3SSs and T6SSs, respectively) are critical virulence determinants in several Gram-negative pathogens. In Burkholderia pseudomallei , the T3SS-3 and T6SS-1 clusters have been implicated in bacterial virulence in mammalian hosts.
Yahua, Chen, Jocelyn, Wong, Guang Wen, Sun, Yichun, Liu, Gek-Yen Gladys, Tan, Yunn-Hwen, Gan   +5 more
openaire   +2 more sources

Functional regulation and cross-talk of type III and type VI secretion systems in Salmonella

Virulence
In Salmonella, the type III and type VI secretion systems (T3SS and T6SS) play critical roles in pathogenicity. The bacterium harbors two distinct T3SSs: T3SS-1, encoded by SPI-1, promotes host cell invasion, whereas T3SS-2 (located within SPI-2 ...
Xingyi Li, Ying Ding, Yu Sun, Yiting Gu, Wanli Feng, Yanyan Jia, Huimin Chen, Songbiao Chen   +7 more
doaj   +1 more source

Assembly and Subcellular Localization of Bacterial Type VI Secretion Systems [PDF]

Annual Review of Microbiology, 2019
Bacteria need to deliver large molecules out of the cytosol to the extracellular space or even across membranes of neighboring cells to influence their environment, prevent predation, defeat competitors, or communicate. A variety of protein-secretion systems have evolved to make this process highly regulated and efficient. The type VI secretion system (
Wang, Jing, Brodmann, Maj, Basler, Marek
openaire   +4 more sources

A family of Type VI secretion system effector proteins that form ion-selective pores

Nature Communications, 2019
Type VI secretion systems (T6SSs) are used by bacteria to inject toxic effector proteins into neighbouring cells. Here, Mariano et al. show that an antibacterial effector from Serratia marcescens forms cation-selective pores that lead to inner-membrane ...
Giuseppina Mariano, Katharina Trunk, David J. Williams, Laura Monlezun, Henrik Strahl, Samantha J. Pitt, Sarah J. Coulthurst   +6 more
doaj   +1 more source

Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation [PDF]

BMC Genomics, 2019
Klebsiella pneumoniae (KP) is an opportunistic pathogen that mainly causes respiratory and urinary tract infections. The frequent occurrence of simultaneously virulent and multiple drug-resistant isolates led WHO to include this species in the list of top priorities for research and development of therapeutic alternatives.
Victor Augusto Araújo Barbosa, Leticia Miranda Santos Lery   +1 more
openaire   +3 more sources

In silico comparative analysis of Aeromonas Type VI Secretion System

Brazilian Journal of Microbiology, 2021
Aeromonas are bacteria broadly spread in the environment, particularly in aquatic habitats and can induce human infections. Several virulence factors have been described associated with bacterial pathogenicity, such as the Type VI Secretion System (T6SS).
Barbara Moriel, Karoline de Campos Prediger, Emanuel M. de Souza, Fábio O. Pedrosa, Cyntia M. T. Fadel-Picheth, Leonardo M. Cruz   +5 more
openaire   +3 more sources

Abundance of bacterial Type VI secretion system components measured by targeted proteomics

Nature Communications, 2019
Type VI secretion systems (T6SS) are important for bacterial interaction, competition and virulence, but the abundance and assembly of their components is still not well understood.
Lin Lin, Emmanuelle Lezan, Alexander Schmidt, Marek Basler   +3 more
doaj   +1 more source