Results 171 to 180 of about 7,552,757 (287)

Murine type VII collagen distorts outcome in human skin graft mouse model for dystrophic epidermolysis bullosa. [PDF]

Exp Dermatol, 2019
Bremer J, Kramer D, Eichhorn DS, Gostyński A, Diercks GFH, Jonkman MF, van den Akker PC, Pasmooij AMG.   +7 more
europepmc   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Novel readthrough agent suppresses nonsense mutations and restores functional type VII collagen and laminin 332 in epidermolysis bullosa. [PDF]

Mol Ther Nucleic Acids
Levian B, Hou Y, Tang X, Bainvoll L, Zheng K, Badarinarayana V, Aghamohammadzadeh S, Chen M.   +7 more
europepmc   +1 more source

Gentamicin induces functional type VII collagen in recessive dystrophic epidermolysis bullosa patients. [PDF]

J Clin Invest, 2017
Woodley DT, Cogan J, Hou Y, Lyu C, Marinkovich MP, Keene D, Chen M.   +6 more
europepmc   +1 more source

Multi‐method analysis for the three‐dimensional reconstruction of muscle fascicles from DiceCT datasets

The Anatomical Record, EarlyView.
Abstract Muscle architecture is a major determinant of muscle performance and, in mammalian lineages, has been correlated with both feeding ecology and locomotor behaviors. Over the past decade, contrast‐enhanced micro‐CT (DiceCT) has emerged as an alternative to traditional dissection‐based measurement.
Aleksandra Ratkiewicz, Michael C. Granatosky, Cassidy E. Davis, Julia Molnar, Adam Hartstone‐Rose, Edwin Dickinson   +5 more
wiley   +1 more source

Intravenous gentamicin therapy induces functional type VII collagen in patients with recessive dystrophic epidermolysis bullosa: an open-label clinical trial. [PDF]

Br J Dermatol
Woodley DT, Hao M, Kwong A, Levian B, Cogan J, Hou Y, Mosallaei D, Kleinman E, Zheng K, Chung C, Kim G, Peng D, Chen M.   +12 more
europepmc   +1 more source

An osteohistological analysis of Triceratops (Ornithischia: Ceratopsidae) cranial ornamentation

The Anatomical Record, EarlyView.
Abstract Ceratopsids are among the most distinctive and well known extinct Cretaceous vertebrates, yet many details regarding the growth and composition of their cranial features are still not fully anatomically described or understood. In particular, striking cranial adornments such as the postorbital horns and parietal‐squamosal frill of Triceratops ...
Kyle D. Obuszewski, N. Adam Smith, Guinevere Rose Brown   +2 more
wiley   +1 more source

Differences in predominant collagen fiber orientation between dorsal and plantar trabecular bone tracts of adult mule deer calcanei suggest strain‐mode‐specific adaptation

The Anatomical Record, EarlyView.
Polarized microscopic images of the outer bone cortex (a and b) and deeper trabecular bone (c and d) of the deer calcaneus in thin cross‐sections. The brighter gray levels reflect more oblique‐to‐transverse collagen fibers in the compression/dorsal bone (a, c) and the darker gray levels reflect more longitudinal collagen in the tension/plantar bone (b,
John G. Skedros, John T. Cronin, Chad S. Mears, Brett W. Richards   +3 more
wiley   +1 more source

Integrated microanatomy and microstructure of the maxillary tooth plate reveal a reinforced feeding system and tougher diet in Late Triassic Hyperodapedontinae (Rhynchosauria, Archosauromorpha)

The Anatomical Record, EarlyView.
Abstract Hyperodapedontine rhynchosaurs possessed a unique oral apparatus, long interpreted as an adaptation for processing abrasive and resistant plant material. However, the microanatomical and histological evidence supporting this interpretation remains poorly documented.
Caio A. Scartezini, Pedro L. B. Pruciano, Brodsky D. M. Farias, Marina B. Soares   +3 more
wiley   +1 more source

Three‐dimensional digital analysis of musteloid masticatory muscle architecture

The Anatomical Record, EarlyView.
Musteloids span an enormous breadth of dietary modes within a single superfamily. In this study, we utilize digital dissection techniques to reconstruct the internal 3D anatomy of muscles within the musteloid feeding apparatus, and explore how dietary specializations might alter the size, orientation, and curvature of fascicles therein.
Cassidy E. Davis, Edwin Dickinson, Madison Manzo, Ashley R. Deutsch, Jillian S. Davis, Michael C. Granatosky, Adam Hartstone‐Rose   +6 more
wiley   +1 more source