Results 1 to 10 of about 21,965 (161)

The potential role of collagen type VII in breast cancer proliferation [PDF]

Cancer Cell International
Background Breast cancer is the most common cancer in women. Cancer cells can persist in a prolonged dormant state for years without any clinical evidence of disease creating an urgent need to better understand the molecular mechanisms leading to relapse.
Sergio Pérez-Díaz, Jessica Lindberg, Luis Oliveros Anerillas, Paul J. Kingham, Malin Sund, Gunilla Rask, Johan Svensson, Malin Jansson, Rebecca Wiberg   +8 more
doaj   +6 more sources

Recombinant humanized type VII collagen for skin repair and regeneration: prospects for reconstructing the dermal-epidermal junction [PDF]

Frontiers in Medicine
Type VII collagen (Col VII) is a key component of the anchoring fibrils at the dermal-epidermal junction (DEJ). It plays a crucial role in maintaining stable adhesion between the epidermis and dermis, promoting wound re-epithelialization, and ensuring ...
Yanyan Lin, Jie Zheng, Xiaobin Lan
doaj   +2 more sources

Excessive collagen type VII mediates pleural fibrosis via increasing extracellular matrix stiffness [PDF]

The Journal of Clinical Investigation
The interaction between cells and extracellular matrix (ECM) has been recognized in the mechanism of fibrotic diseases. Collagen type VII (collagen VII) is an ECM component that plays an important role in cell-ECM interaction, particularly in cell ...
Qian Li, Xin-Liang He, Shuai-Jun Chen, Qian Niu, Tan-Ze Cao, Xiao-Lin Cui, Zi-Heng Jia, He-De Zhang, Xiao Feng, Ye-Han Jiang, Li-Mei Liang, Pei-Pei Cheng, Shi-He Hu, Liang Xiong, Meng Wang, Hong Ye, Wan-Li Ma   +16 more
doaj   +2 more sources

Diagnostic potential of Type VII Collagen during oral carcinogenesis [PDF]

Journal of Applied Oral Science, 2023
Type VII collagen (Col7) is a major component of anchoring fibrils. Col7 plays a role in tumor development and aggressiveness of cutaneous squamous cell carcinoma of recessive dystrophic epidermolysis bullosa.
Sopee POOMSAWAT, Abdulshukor KARIYA, Thirayost NIMMANON, Theerachai KOSANWAT, Rachai JUENGSOMJIT, SANGUANSIN Sirima   +5 more
doaj   +4 more sources

Laminin 5 Binds the NC-1 Domain of Type VII Collagen [PDF]

Journal of Cell Biology, 1997
Mutational analyses of genes that encode components of the anchoring complex underlying the basolateral surface of external epithelia indicate that this structure is the major element providing for resistance to external friction. Ultrastructurally, laminin 5 (α3β3γ2; a component of the anchoring filament) appears as a thin filament bridging the ...
Patricia Rousselle, Florence RUGGIERO, Douglas R Keene   +2 more
exaly   +4 more sources

Diagnosis of Epidermolysis Bullosa Acquisita: Multicentre Comparison of Different Assays for Serum Anti-type VII Collagen Reactivity

Acta Dermato-Venereologica, 2021
Epidermolysis bullosa acquisita is a pemphigoid disease characterized by autoantibodies against type VII collagen. This study compared the sensitivity and specificity of 6 diagnostic assays: type VII collagen non-collagenous domains enzyme-linked ...
Maike M. Holtsche, Nina van Beek, Takashi Hashimoto, Giovanni Di Zenzo, Detlef Zillikens, Catherine Prost-Squarcioni, Matthias Titeux, Alain Hovnanian, Enno Schmidt, Stephanie Goletz   +9 more
doaj   +1 more source

CRISPR/Cas9-Mediated Generation of COL7A1-Deficient Keratinocyte Model of Recessive Dystrophic Epidermolysis Bullosa [PDF]

Cell Journal, 2023
Objective: Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic skin fragility and ultimately lethal blisteringdisease caused by mutations in the COL7A1 gene which is responsible for coding type VII collagen.
Farzad Alipour, Mana Ahmadraji, Elham Yektadoost, Parvaneh Mohammadi, Hossein Baharvand, Mohsen Basiri   +5 more
doaj   +1 more source

A novel deletion and two recurrent substitutions on type VII collagen gene in seven Iranian patients with epidermolysis bullosa [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): Epidermolysis bullosa is one of the most important series of mechano-bullous heritable skin disorders which is categorized into four major types according to the layer that bullae forms within basement membrane zone.
Armita Kakavand Hamidi, Mohammad Moghaddam, Nasim Hatamnejadian, Ahmad Ebrahimi   +3 more
doaj   +1 more source

Type VII collagen in Alport syndrome [PDF]

Nephrology Dialysis Transplantation, 2007
Absence or segmental distribution of the alpha5(IV) collagen chain along the epidermal basement membrane (EBM) is diagnostic of X-linked Alport syndrome (X-AS), but the typical morphologic alterations usually observed along the glomerular basement membrane (GBM) are lacking. However, several differences in protein composition exist between GBM and EBM,
GIANNAKAKIS, Konstantinos, L. Massella, D. Grassetti, F. Dotta, M. Perez, A. O. Muda   +5 more
openaire   +4 more sources

Type VII Collagen Expression in the Human Vitreoretinal Interface, Corpora Amylacea and Inner Retinal Layers.

PLoS ONE, 2015
Type VII collagen, as a major component of anchoring fibrils found at basement membrane zones, is crucial in anchoring epithelial tissue layers to their underlying stroma.
Bart Wullink, Hendri H Pas, Roelofje J Van der Worp, Roel Kuijer, Leonoor I Los   +4 more
doaj   +1 more source